SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xtw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		4 / 6 SER A 256
VAL A 228
TYR A 230
ASP A 294
 None
 1.49A 2x45A-5xtwA:
undetectable		 2x45A-5xtwA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 185
PHE A 174
GLY A 195
THR A 196
THR A 197
 None
 1.21A 2zifA-5xtwA:
undetectable		 2zifA-5xtwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 PHE A 174
GLY A 195
LYS A 204
ASP A 203
THR A 197
 None
 1.22A 3a25A-5xtwA:
undetectable		 3a25A-5xtwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ARG A 151
ARG A  23
ILE A 141
 None
 0.88A 4b7qA-5xtwA:
undetectable		 4b7qA-5xtwA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ARG A 151
ARG A  23
ILE A 141
 None
 0.75A 4b7qC-5xtwA:
undetectable		 4b7qC-5xtwA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.90A 6b0iB-5xtwA:
undetectable		 6b0iB-5xtwA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A 273
LEU A 277
SER A 246
GLY A 161
LEU A 160
 None
 0.84A 6b0lB-5xtwA:
undetectable		 6b0lB-5xtwA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens) 		4 / 6 HIS A 377
TYR A 484
GLU A 380
LYS A 382
 None
 1.33A 6d8pA-5xtwA:
undetectable		 6d8pA-5xtwA:
undetectable