SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_0 (FTSJ)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	5 / 12	GLY M 24 GLY M 350 GLY M 351 LEU M 20 LEU M 19	None	0.87A	1eizA-5xu1M: undetectable	1eizA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_0 (FTSJ)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	5 / 12	GLY M 24 GLY M 350 GLY M 351 LEU M 20 LEU M 19	None	0.85A	1ej0A-5xu1M: undetectable	1ej0A-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.15A	1p6kA-5xu1M: undetectable	1p6kA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.16A	1p6kB-5xu1M: undetectable	1p6kB-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS6_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.15A	1rs6A-5xu1M: undetectable	1rs6A-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS7_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.08A	1rs7B-5xu1M: undetectable	1rs7B-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZQ_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.14A	1zzqA-5xu1M: undetectable	1zzqA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_A_MTLA870_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.10A	1zzuA-5xu1M: undetectable	1zzuA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.18A	1zzuB-5xu1M: 1.1	1zzuB-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_A_SAMA301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	5 / 12	LEU A 29 LEU A 50 SER A 45 ALA A 38 ALA A 210	None None MG A 301 ( 4.5A) None None	0.90A	2br4A-5xu1A: undetectable	2br4A-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	5 / 12	LEU A 29 LEU A 50 SER A 45 ALA A 38 ALA A 210	None None MG A 301 ( 4.5A) None None	0.97A	2br4F-5xu1A: undetectable	2br4F-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIJ_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.80A	2eijN-5xu1A: undetectable 2eijW-5xu1A: undetectable	2eijN-5xu1A: undetectable 2eijW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIK_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.83A	2eikN-5xu1A: undetectable 2eikW-5xu1A: undetectable	2eikN-5xu1A: undetectable 2eikW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIL_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.79A	2eilN-5xu1A: undetectable 2eilW-5xu1A: undetectable	2eilN-5xu1A: undetectable 2eilW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GVC_B_MMZB501_1 (MONOOXYGENASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	3 / 3	ASN M 56 TYR M 140 SER M 236	None	0.83A	2gvcB-5xu1M: undetectable	2gvcB-5xu1M: 11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GVC_E_MMZE501_1 (MONOOXYGENASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	3 / 3	ASN M 56 TYR M 140 SER M 236	None	0.82A	2gvcE-5xu1M: undetectable	2gvcE-5xu1M: 11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA501_1 (CYTOCHROME P450 2C8)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	5 / 11	GLY M 215 SER M 175 ALA M 183 PRO M 218 ILE M 166	None	1.07A	2nnhA-5xu1M: 0.0	2nnhA-5xu1M: 11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZXW_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 7	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.78A	2zxwN-5xu1A: undetectable 2zxwW-5xu1A: undetectable	2zxwN-5xu1A: undetectable 2zxwW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABL_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.77A	3ablN-5xu1A: undetectable 3ablW-5xu1A: undetectable	3ablN-5xu1A: undetectable 3ablW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG3_W_CHDW1059_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.76A	3ag3N-5xu1A: undetectable 3ag3W-5xu1A: undetectable	3ag3N-5xu1A: undetectable 3ag3W-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ASN_W_CHDW1059_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.80A	3asnN-5xu1A: undetectable 3asnW-5xu1A: undetectable	3asnN-5xu1A: undetectable 3asnW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AVP_A_MV2A313_1 (PANTOTHENATE KINASE)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 7	VAL A 31 ASP A 224 LEU A 29 ILE A 197	None	0.93A	3avpA-5xu1A: undetectable	3avpA-5xu1A: 16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AVP_A_MV2A313_1 (PANTOTHENATE KINASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 7	ASP M 49 TYR M 201 ILE M 219 ASN M 146	None	0.98A	3avpA-5xu1M: undetectable	3avpA-5xu1M: 13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BUF_A_AEGA394_0 (BETA-SECRETASE 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 5	LEU A 167 ILE A 39 ILE A 165 GLY A 55	None	0.92A	3bufA-5xu1A: undetectable	3bufA-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE P)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	VAL M 144 ILE M 234 ASN M 222 GLY M 136	None	0.81A	3hjoB-5xu1M: undetectable	3hjoB-5xu1M: 14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N62_A_MTLA870_0 (NITRIC OXIDE SYNTHASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.00A	3n62A-5xu1M: undetectable	3n62A-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N62_B_MTLB870_0 (NITRIC OXIDE SYNTHASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.06A	3n62B-5xu1M: undetectable	3n62B-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N66_B_MTLB870_0 (NITRIC OXIDE SYNTHASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.04A	3n66B-5xu1M: undetectable	3n66B-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	5 / 12	ALA M 363 LEU M 367 LEU M 368 ILE M 373 GLY M 375	None	1.14A	3q95A-5xu1M: undetectable	3q95A-5xu1M: 15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOS_B_0LIB1000_2 (EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	5 / 9	ILE A 183 LEU A 187 ILE A 197 MET A 51 ILE A 166	None	1.21A	3zosB-5xu1A: undetectable	3zosB-5xu1A: 15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AQL_A_TXCA1452_2 (GUANINE DEAMINASE)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 5	HIS A 202 LEU A 50 LEU A 167 ASP A 58	None	1.25A	4aqlA-5xu1A: undetectable	4aqlA-5xu1A: 10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_A_NPSA601_1 (SERUM ALBUMIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	5 / 11	VAL M 307 GLY M 306 THR M 21 LEU M 346 SER M 10	None	1.33A	4or0A-5xu1M: undetectable	4or0A-5xu1M: 7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R3A_A_RBFA402_1 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	5 / 12	GLN A 151 ALA A 168 ILE A 166 ILE A 183 LEU A 186	None	1.10A	4r3aA-5xu1A: undetectable	4r3aA-5xu1A: 11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R82_A_ACTA205_0 (OXIDOREDUCTASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 5	SER M 314 ARG M 318 GLU M 342 PHE M 339	None	1.23A	4r82A-5xu1M: undetectable 4r82B-5xu1M: undetectable	4r82A-5xu1M: undetectable 4r82B-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1A_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 6	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.76A	5b1aN-5xu1A: undetectable 5b1aW-5xu1A: undetectable	5b1aN-5xu1A: undetectable 5b1aW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K50_A_ACTA1403_0 (L-THREONINE 3-DEHYDROGENASE)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 5	SER M 31 VAL M 32 GLY M 297 ALA M 296	None	1.05A	5k50A-5xu1M: undetectable	5k50A-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGK_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	3 / 3	VAL M 59 TYR M 269 GLN M 270	None	0.72A	5qgkA-5xu1M: undetectable	5qgkA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGR_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	3 / 3	VAL M 59 TYR M 269 GLN M 270	None	0.69A	5qgrA-5xu1M: undetectable	5qgrA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGT_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	3 / 3	VAL M 59 TYR M 269 GLN M 270	None	0.72A	5qgtA-5xu1M: undetectable	5qgtA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUN_A_MTLA805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.13A	5vunA-5xu1M: undetectable	5vunA-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUN_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.15A	5vunB-5xu1M: undetectable	5vunB-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUO_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.13A	5vuoB-5xu1M: undetectable	5vuoB-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X23_A_LSNA503_1 (CYTOCHROME P450 2C9)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 5	GLY A 180 THR A 179 ASN A 181 LYS A 178	None	1.24A	5x23A-5xu1A: undetectable	5x23A-5xu1A: 10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDX_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.76A	5xdxN-5xu1A: undetectable 5xdxW-5xu1A: undetectable	5xdxN-5xu1A: undetectable 5xdxW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCO_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.75A	5zcoA-5xu1A: undetectable 5zcoJ-5xu1A: undetectable	5zcoA-5xu1A: undetectable 5zcoJ-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCQ_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	4 / 8	ILE A 88 LEU A 167 PHE A 90 THR A 59	None	0.78A	5zcqN-5xu1A: undetectable 5zcqW-5xu1A: undetectable	5zcqN-5xu1A: undetectable 5zcqW-5xu1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AUU_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5xu1	ABC TRANSPORTER PERMEAE (Streptococcus pneumoniae)	4 / 8	ARG M 240 ASN M 56 GLN M 54 ASN M 242	None	1.16A	6auuB-5xu1M: undetectable	6auuB-5xu1M: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AZ3_1_PAR11803_1 (RRNA ALPHA RIBOSOMAL PROTEIN EL18)	5xu1	ABC TRANSPORTER ATP-BINDING PROTEIN (Streptococcus pneumoniae)	3 / 3	SER A 117 LYS A 120 SER A 119	None	0.67A	6az3P-5xu1A: undetectable	6az3P-5xu1A: 22.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EIZ_A_SAMA301_0","FTSJ","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",5,"GLY M  24;GLY M 350;GLY M 351;LEU M  20;LEU M  19","None","0.87A","1eizA-5xu1M:undetectable","1eizA-5xu1M:undetectable"],["1EJ0_A_SAMA301_0","FTSJ","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",5,"GLY M  24;GLY M 350;GLY M 351;LEU M  20;LEU M  19","None","0.85A","1ej0A-5xu1M:undetectable","1ej0A-5xu1M:undetectable"],["1P6K_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.15A","1p6kA-5xu1M:undetectable","1p6kA-5xu1M:undetectable"],["1P6K_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.16A","1p6kB-5xu1M:undetectable","1p6kB-5xu1M:undetectable"],["1RS6_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.15A","1rs6A-5xu1M:undetectable","1rs6A-5xu1M:undetectable"],["1RS7_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.08A","1rs7B-5xu1M:undetectable","1rs7B-5xu1M:undetectable"],["1ZZQ_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.14A","1zzqA-5xu1M:undetectable","1zzqA-5xu1M:undetectable"],["1ZZU_A_MTLA870_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.10A","1zzuA-5xu1M:undetectable","1zzuA-5xu1M:undetectable"],["1ZZU_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.18A","1zzuB-5xu1M:1.1","1zzuB-5xu1M:undetectable"],["2BR4_A_SAMA301_0","CEPHALOSPORIN HYDROXYLASE CMCI","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",5,"LEU A  29;LEU A  50;SER A  45;ALA A  38;ALA A 210","None;None; MG A 301 ( 4.5A);None;None","0.90A","2br4A-5xu1A:undetectable","2br4A-5xu1A:undetectable"],["2BR4_F_SAMF301_0","CEPHALOSPORIN HYDROXYLASE CMCI","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",5,"LEU A  29;LEU A  50;SER A  45;ALA A  38;ALA A 210","None;None; MG A 301 ( 4.5A);None;None","0.97A","2br4F-5xu1A:undetectable","2br4F-5xu1A:undetectable"],["2EIJ_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.80A","2eijN-5xu1A:undetectable;2eijW-5xu1A:undetectable","2eijN-5xu1A:undetectable;2eijW-5xu1A:undetectable"],["2EIK_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.83A","2eikN-5xu1A:undetectable;2eikW-5xu1A:undetectable","2eikN-5xu1A:undetectable;2eikW-5xu1A:undetectable"],["2EIL_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.79A","2eilN-5xu1A:undetectable;2eilW-5xu1A:undetectable","2eilN-5xu1A:undetectable;2eilW-5xu1A:undetectable"],["2GVC_B_MMZB501_1","MONOOXYGENASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",3,"ASN M  56;TYR M 140;SER M 236","None","0.83A","2gvcB-5xu1M:undetectable","2gvcB-5xu1M:11.86"],["2GVC_E_MMZE501_1","MONOOXYGENASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",3,"ASN M  56;TYR M 140;SER M 236","None","0.82A","2gvcE-5xu1M:undetectable","2gvcE-5xu1M:11.86"],["2NNH_A_9CRA501_1","CYTOCHROME P450 2C8","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",5,"GLY M 215;SER M 175;ALA M 183;PRO M 218;ILE M 166","None","1.07A","2nnhA-5xu1M:0.0","2nnhA-5xu1M:11.55"],["2ZXW_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.78A","2zxwN-5xu1A:undetectable;2zxwW-5xu1A:undetectable","2zxwN-5xu1A:undetectable;2zxwW-5xu1A:undetectable"],["3ABL_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.77A","3ablN-5xu1A:undetectable;3ablW-5xu1A:undetectable","3ablN-5xu1A:undetectable;3ablW-5xu1A:undetectable"],["3AG3_W_CHDW1059_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.76A","3ag3N-5xu1A:undetectable;3ag3W-5xu1A:undetectable","3ag3N-5xu1A:undetectable;3ag3W-5xu1A:undetectable"],["3ASN_W_CHDW1059_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.80A","3asnN-5xu1A:undetectable;3asnW-5xu1A:undetectable","3asnN-5xu1A:undetectable;3asnW-5xu1A:undetectable"],["3AVP_A_MV2A313_1","PANTOTHENATE KINASE","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"VAL A  31;ASP A 224;LEU A  29;ILE A 197","None","0.93A","3avpA-5xu1A:undetectable","3avpA-5xu1A:16.42"],["3AVP_A_MV2A313_1","PANTOTHENATE KINASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ASP M  49;TYR M 201;ILE M 219;ASN M 146","None","0.98A","3avpA-5xu1M:undetectable","3avpA-5xu1M:13.83"],["3BUF_A_AEGA394_0","BETA-SECRETASE 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"LEU A 167;ILE A  39;ILE A 165;GLY A  55","None","0.92A","3bufA-5xu1A:undetectable","3bufA-5xu1A:undetectable"],["3HJO_B_EAAB211_1","GLUTATHIONE S-TRANSFERASE P","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"VAL M 144;ILE M 234;ASN M 222;GLY M 136","None","0.81A","3hjoB-5xu1M:undetectable","3hjoB-5xu1M:14.57"],["3N62_A_MTLA870_0","NITRIC OXIDE SYNTHASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.00A","3n62A-5xu1M:undetectable","3n62A-5xu1M:undetectable"],["3N62_B_MTLB870_0","NITRIC OXIDE SYNTHASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.06A","3n62B-5xu1M:undetectable","3n62B-5xu1M:undetectable"],["3N66_B_MTLB870_0","NITRIC OXIDE SYNTHASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.04A","3n66B-5xu1M:undetectable","3n66B-5xu1M:undetectable"],["3Q95_A_ESLA700_1","ESTROGEN RECEPTOR","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",5,"ALA M 363;LEU M 367;LEU M 368;ILE M 373;GLY M 375","None","1.14A","3q95A-5xu1M:undetectable","3q95A-5xu1M:15.77"],["3ZOS_B_0LIB1000_2","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",5,"ILE A 183;LEU A 187;ILE A 197;MET A  51;ILE A 166","None","1.21A","3zosB-5xu1A:undetectable","3zosB-5xu1A:15.90"],["4AQL_A_TXCA1452_2","GUANINE DEAMINASE","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"HIS A 202;LEU A  50;LEU A 167;ASP A  58","None","1.25A","4aqlA-5xu1A:undetectable","4aqlA-5xu1A:10.99"],["4OR0_A_NPSA601_1","SERUM ALBUMIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",5,"VAL M 307;GLY M 306;THR M  21;LEU M 346;SER M  10","None","1.33A","4or0A-5xu1M:undetectable","4or0A-5xu1M:7.56"],["4R3A_A_RBFA402_1","BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",5,"GLN A 151;ALA A 168;ILE A 166;ILE A 183;LEU A 186","None","1.10A","4r3aA-5xu1A:undetectable","4r3aA-5xu1A:11.78"],["4R82_A_ACTA205_0","OXIDOREDUCTASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"SER M 314;ARG M 318;GLU M 342;PHE M 339","None","1.23A","4r82A-5xu1M:undetectable;4r82B-5xu1M:undetectable","4r82A-5xu1M:undetectable;4r82B-5xu1M:undetectable"],["5B1A_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.76A","5b1aN-5xu1A:undetectable;5b1aW-5xu1A:undetectable","5b1aN-5xu1A:undetectable;5b1aW-5xu1A:undetectable"],["5K50_A_ACTA1403_0","L-THREONINE 3-DEHYDROGENASE","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"SER M  31;VAL M  32;GLY M 297;ALA M 296","None","1.05A","5k50A-5xu1M:undetectable","5k50A-5xu1M:undetectable"],["5QGK_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",3,"VAL M  59;TYR M 269;GLN M 270","None","0.72A","5qgkA-5xu1M:undetectable","5qgkA-5xu1M:undetectable"],["5QGR_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",3,"VAL M  59;TYR M 269;GLN M 270","None","0.69A","5qgrA-5xu1M:undetectable","5qgrA-5xu1M:undetectable"],["5QGT_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",3,"VAL M  59;TYR M 269;GLN M 270","None","0.72A","5qgtA-5xu1M:undetectable","5qgtA-5xu1M:undetectable"],["5VUN_A_MTLA805_0","NITRIC OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.13A","5vunA-5xu1M:undetectable","5vunA-5xu1M:undetectable"],["5VUN_B_MTLB805_0","NITRIC OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.15A","5vunB-5xu1M:undetectable","5vunB-5xu1M:undetectable"],["5VUO_B_MTLB805_0","NITRIC OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.13A","5vuoB-5xu1M:undetectable","5vuoB-5xu1M:undetectable"],["5X23_A_LSNA503_1","CYTOCHROME P450 2C9","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"GLY A 180;THR A 179;ASN A 181;LYS A 178","None","1.24A","5x23A-5xu1A:undetectable","5x23A-5xu1A:10.68"],["5XDX_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.76A","5xdxN-5xu1A:undetectable;5xdxW-5xu1A:undetectable","5xdxN-5xu1A:undetectable;5xdxW-5xu1A:undetectable"],["5ZCO_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.75A","5zcoA-5xu1A:undetectable;5zcoJ-5xu1A:undetectable","5zcoA-5xu1A:undetectable;5zcoJ-5xu1A:undetectable"],["5ZCQ_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",4,"ILE A  88;LEU A 167;PHE A  90;THR A  59","None","0.78A","5zcqN-5xu1A:undetectable;5zcqW-5xu1A:undetectable","5zcqN-5xu1A:undetectable;5zcqW-5xu1A:undetectable"],["6AUU_B_MTLB805_0","NITRIC OXIDE SYNTHASE, BRAIN","5xu1","ABC TRANSPORTER PERMEAE","Streptococcus pneumoniae",4,"ARG M 240;ASN M  56;GLN M  54;ASN M 242","None","1.16A","6auuB-5xu1M:undetectable","6auuB-5xu1M:undetectable"],["6AZ3_1_PAR11803_1","RRNA ALPHA;RIBOSOMAL PROTEIN EL18","5xu1","ABC TRANSPORTER ATP-BINDING PROTEIN","Streptococcus pneumoniae",3,"SER A 117;LYS A 120;SER A 119","None","0.67A","6az3P-5xu1A:undetectable","6az3P-5xu1A:22.09"]]