SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 7 THR A 260
TRP A 229
GLY A 214
TYR A 195
 None
 1.02A 1bu5A-5xu6A:
undetectable		 1bu5A-5xu6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 7 SER A 357
ASP A 385
GLU A 151
GLU A 237
 None
 1.12A 1knyA-5xu6A:
undetectable
1knyB-5xu6A:
undetectable		 1knyA-5xu6A:
19.18
1knyB-5xu6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 5 GLY A  40
GLN A  41
VAL A 140
SER A  37
 None
 1.48A 1p6kB-5xu6A:
undetectable		 1p6kB-5xu6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 5 GLY A  40
GLN A  41
VAL A 140
SER A  37
 None
 1.37A 1zzuA-5xu6A:
undetectable		 1zzuA-5xu6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 5 ALA A 398
ASP A 401
GLU A 402
TRP A 405
 None
 1.37A 2xrzA-5xu6A:
undetectable		 2xrzA-5xu6A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 8 PRO A 160
HIS A 164
SER A 289
ILE A 288
 None
 1.09A 3sfeB-5xu6A:
undetectable
3sfeC-5xu6A:
undetectable		 3sfeB-5xu6A:
20.38
3sfeC-5xu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		5 / 10 LEU A 247
LEU A 248
LEU A 255
ARG A 245
TRP A 219
 None
 1.24A 4mk4A-5xu6A:
undetectable		 4mk4A-5xu6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 6 SER A 226
GLY A 214
ILE A 152
TRP A 229
 None
 0.92A 5j4nA-5xu6A:
undetectable		 5j4nA-5xu6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		4 / 6 ARG A 189
ALA A 190
PRO A 193
PHE A 180
 None
 1.25A 5odqA-5xu6A:
undetectable		 5odqA-5xu6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5xu6 INOSITOL-PENTAKISPHO
SPHATE 2-KINASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 310
ILE A 394
PRO A 303
PHE A 295
ASP A 306
 None
 1.48A 6fbpA-5xu6A:
undetectable
6fbpB-5xu6A:
undetectable		 6fbpA-5xu6A:
11.08
6fbpB-5xu6A:
11.08