SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		5 / 12 PHE A  92
LEU A  97
GLY A   3
ALA A  52
GLY A  60
 None
 1.01A 1igxA-5xukA:
undetectable		 1igxA-5xukA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		6 / 10 LEU A  97
GLY A   3
ALA A  52
ASP A   5
GLY A  60
VAL A  59
 None
 1.38A 3oxwA-5xukA:
undetectable		 3oxwA-5xukA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		6 / 10 LEU A  97
GLY A   3
ALA A  52
ASP A   5
GLY A  60
VAL A  59
 None
 1.36A 3oxwC-5xukA:
undetectable		 3oxwC-5xukA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		4 / 8 ILE A  82
ILE A  72
VAL A 112
ILE A 101
 None
None
None
COA  A 201 (-3.9A)
 0.81A 3p4wC-5xukA:
undetectable		 3p4wC-5xukA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		5 / 10 VAL A   7
ALA A 108
PHE A  47
SER A  41
GLY A  45
 None
 1.16A 4mmdA-5xukA:
undetectable		 4mmdA-5xukA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		5 / 12 VAL A   7
ALA A 108
PHE A  47
SER A  41
GLY A  45
 None
 1.18A 4mmdB-5xukA:
undetectable		 4mmdB-5xukA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A  84
SER A  29
PHE A  67
GLU A  32
LEU A  65
 None
 1.22A 5czyA-5xukA:
undetectable		 5czyA-5xukA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5xuk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Helicobacter
pylori) 		4 / 6 GLU A  32
LEU A  28
LYS A  50
LEU A  49
 None
 1.10A 5yvnA-5xukA:
undetectable		 5yvnA-5xukA:
undetectable