SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5xun ACETYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 4 THR A  64
LEU A  94
LEU A 161
GLN A 152
 None
 1.12A 1fbmA-5xunA:
undetectable		 1fbmA-5xunA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5xun ACETYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A   5
VAL A  51
SER A  52
SER A 102
LEU A  36
 None
 1.50A 1rk3A-5xunA:
undetectable		 1rk3A-5xunA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5xun ACETYLTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 9 GLY A 128
PRO A  90
ILE A 168
PHE A 133
PHE A  70
 None
 1.47A 3ko0H-5xunA:
undetectable
3ko0I-5xunA:
undetectable		 3ko0H-5xunA:
21.39
3ko0I-5xunA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5xun ACETYLTRANSFERASE
(Klebsiella
pneumoniae) 		3 / 3 ASP A 100
GLU A  26
SER A  52
 None
 0.86A 3p2kA-5xunA:
undetectable		 3p2kA-5xunA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5xun ACETYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 5 LEU A  45
THR A  64
THR A  93
GLY A  95
 None
None
None
ACO  A 201 (-4.8A)
 0.30A 6gtqA-5xunA:
24.7		 6gtqA-5xunA:
65.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5xun ACETYLTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 6 LEU A  45
THR A  64
GLY A  95
ARG A  96
 None
None
ACO  A 201 (-4.8A)
None
 0.37A 6gtqB-5xunA:
23.9
6gtqD-5xunA:
undetectable		 6gtqB-5xunA:
65.73
6gtqD-5xunA:
14.53