SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 806
ILE A 781
ILE A 741
HIS A 723
ILE A 779
 None
 1.15A 4dtaA-5xuoA:
undetectable		 4dtaA-5xuoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		6 / 12 PHE A 810
LEU A 802
SER A 801
ALA A 805
ARG A 724
ILE A 781
 None
 1.41A 4krhB-5xuoA:
undetectable		 4krhB-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.78A 4qvlK-5xuoA:
undetectable
4qvlL-5xuoA:
undetectable		 4qvlK-5xuoA:
17.99
4qvlL-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.78A 4qvlY-5xuoA:
undetectable
4qvlZ-5xuoA:
undetectable		 4qvlY-5xuoA:
17.99
4qvlZ-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.79A 4qvmK-5xuoA:
undetectable
4qvmL-5xuoA:
undetectable		 4qvmK-5xuoA:
17.99
4qvmL-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.79A 4qvmY-5xuoA:
undetectable
4qvmZ-5xuoA:
undetectable		 4qvmY-5xuoA:
17.99
4qvmZ-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.80A 4qvpK-5xuoA:
undetectable
4qvpL-5xuoA:
undetectable		 4qvpK-5xuoA:
17.99
4qvpL-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.79A 4qvpY-5xuoA:
undetectable
4qvpZ-5xuoA:
undetectable		 4qvpY-5xuoA:
17.99
4qvpZ-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.77A 4qw1K-5xuoA:
undetectable
4qw1L-5xuoA:
undetectable		 4qw1K-5xuoA:
17.99
4qw1L-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.76A 4qw1Y-5xuoA:
undetectable
4qw1Z-5xuoA:
undetectable		 4qw1Y-5xuoA:
17.99
4qw1Z-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.78A 4qw3K-5xuoA:
undetectable
4qw3L-5xuoA:
undetectable		 4qw3K-5xuoA:
17.99
4qw3L-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.78A 4qw3Y-5xuoA:
undetectable
4qw3Z-5xuoA:
undetectable		 4qw3Y-5xuoA:
17.99
4qw3Z-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.77A 5bxnK-5xuoA:
undetectable
5bxnL-5xuoA:
undetectable		 5bxnK-5xuoA:
17.99
5bxnL-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.77A 5bxnY-5xuoA:
undetectable
5bxnZ-5xuoA:
undetectable		 5bxnY-5xuoA:
17.99
5bxnZ-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.79A 5d0xK-5xuoA:
undetectable
5d0xL-5xuoA:
undetectable		 5d0xK-5xuoA:
17.99
5d0xL-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.79A 5d0xY-5xuoA:
undetectable
5d0xZ-5xuoA:
undetectable		 5d0xY-5xuoA:
17.99
5d0xZ-5xuoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 727
LEU A 761
ILE A 741
HIS A 723
VAL A 756
 None
 1.13A 5dpdA-5xuoA:
undetectable		 5dpdA-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 748
GLN A 773
CYH A 824
 None
 0.81A 5icxA-5xuoA:
undetectable
5icxE-5xuoA:
undetectable		 5icxA-5xuoA:
13.02
5icxE-5xuoA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 809
ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 1.17A 5mvnB-5xuoA:
2.2		 5mvnB-5xuoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_C_PFLC407_1
(PROTON-GATED ION
CHANNEL)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 809
ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 1.17A 5mvnC-5xuoA:
2.2		 5mvnC-5xuoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 10 TYR A 809
ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 1.17A 5mvnD-5xuoA:
2.2		 5mvnD-5xuoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 781
VAL A 744
THR A 820
ILE A 823
 None
 0.90A 5mzrE-5xuoA:
2.2		 5mzrE-5xuoA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 728
LEU A 732
ARG A 733
 None
 0.93A 5yw0A-5xuoA:
undetectable		 5yw0A-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 805
ALA A 808
ALA A 819
ALA A 822
 None
 0.86A 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable		 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 819
ALA A 822
ALA A 805
ALA A 808
 None
 0.86A 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable		 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.77A 6hwdK-5xuoA:
undetectable
6hwdL-5xuoA:
undetectable		 6hwdK-5xuoA:
19.77
6hwdL-5xuoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5xuo POLYKETIDE SYNTHASE
PKS13
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 819
ALA A 822
GLY A 813
GLY A 812
ALA A 808
 None
 0.77A 6hwdY-5xuoA:
undetectable
6hwdZ-5xuoA:
undetectable		 6hwdY-5xuoA:
19.77
6hwdZ-5xuoA:
19.54