SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5xup TELOMERIC
REPEAT-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 ILE A 108
THR A 254
THR A 130
ARG A  88
 None
 1.07A 3nxuA-5xupA:
undetectable		 3nxuA-5xupA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5xup TELOMERIC
REPEAT-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 5 ILE A 240
ALA A 154
MET A 236
PHE A 128
 None
 0.99A 4dc3B-5xupA:
undetectable		 4dc3B-5xupA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5xup TELOMERIC
REPEAT-BINDING
FACTOR 1
(Homo
sapiens) 		3 / 3 PHE A  81
ARG A  88
ALA A 261
 None
 0.97A 6ecfB-5xupA:
undetectable		 6ecfB-5xupA:
19.41