SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xv5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 6 LYS A 130
LYS A 118
LEU A 122
GLU A 123
 None
 1.12A 3h5gB-5xv5A:
undetectable
3h5gC-5xv5A:
undetectable		 3h5gB-5xv5A:
undetectable
3h5gC-5xv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 6 VAL A 155
LEU A 153
LEU A 138
PHE A 197
 None
 1.05A 4o1zA-5xv5A:
undetectable		 4o1zA-5xv5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 6 LEU A 161
ASN A 162
LEU A 170
VAL A 223
 None
 1.11A 4okbA-5xv5A:
undetectable		 4okbA-5xv5A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 8 GLU A 173
GLY A 225
THR A 139
PHE A   5
 None
 0.99A 5flcB-5xv5A:
undetectable		 5flcB-5xv5A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		4 / 8 GLU A 173
GLY A 225
THR A 139
PHE A   5
 None
 0.98A 5flcF-5xv5A:
undetectable		 5flcF-5xv5A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		5 / 9 ILE A 129
VAL A 155
LEU A 153
ILE A   6
LEU A 127
 None
 1.19A 5iepA-5xv5A:
undetectable		 5iepA-5xv5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5xv5 CONSERVED PROTEIN
(Methanosarcina
mazei) 		3 / 3 GLU A  39
HIS A  43
ARG A  72
 None
 0.89A 5uunA-5xv5A:
undetectable		 5uunA-5xv5A:
undetectable