SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 TYR A 517
VAL A 196
ILE A 193
GLU A 543
 None
 0.99A 1j96B-5xv7A:
undetectable		 1j96B-5xv7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 512
HIS A 565
GLY A 525
SER A 526
LEU A 580
 None
 1.31A 1kyvA-5xv7A:
undetectable
1kyvB-5xv7A:
undetectable		 1kyvA-5xv7A:
21.15
1kyvB-5xv7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 603
ASP A 596
LEU A 597
ILE A 569
LEU A 520
 None
 1.10A 1qzfA-5xv7A:
undetectable		 1qzfA-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 603
ASP A 596
LEU A 597
ILE A 569
LEU A 520
 None
 1.09A 1qzfB-5xv7A:
undetectable		 1qzfB-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 603
ASP A 596
LEU A 597
ILE A 569
LEU A 520
 None
 1.10A 1qzfC-5xv7A:
undetectable		 1qzfC-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 603
ASP A 596
LEU A 597
ILE A 569
LEU A 520
 None
 1.10A 1qzfD-5xv7A:
undetectable		 1qzfD-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 603
ASP A 596
LEU A 597
ILE A 569
LEU A 520
 None
 1.09A 1qzfE-5xv7A:
undetectable		 1qzfE-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 107
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.6A)
None
None
None
None
 0.53A 1uwhA-5xv7A:
21.0		 1uwhA-5xv7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 107
LYS A 109
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
 0.69A 1uwhB-5xv7A:
20.9		 1uwhB-5xv7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  94
ALA A 107
GLU A 124
LEU A 203
HIS A 211
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
 0.58A 1uwjA-5xv7A:
5.4		 1uwjA-5xv7A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 GLY A 525
SER A 526
LEU A 580
ILE A 512
HIS A 565
 None
 1.26A 2a58A-5xv7A:
undetectable
2a58E-5xv7A:
undetectable		 2a58A-5xv7A:
21.15
2a58E-5xv7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 512
HIS A 565
GLY A 525
SER A 526
LEU A 580
 None
 1.27A 2a58A-5xv7A:
undetectable
2a58B-5xv7A:
undetectable		 2a58A-5xv7A:
21.15
2a58B-5xv7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 512
HIS A 565
GLY A 525
SER A 526
LEU A 580
 None
 1.26A 2a58B-5xv7A:
undetectable
2a58C-5xv7A:
undetectable		 2a58B-5xv7A:
21.15
2a58C-5xv7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 512
HIS A 565
GLY A 525
SER A 526
LEU A 580
 None
 1.25A 2a58C-5xv7A:
undetectable
2a58D-5xv7A:
undetectable		 2a58C-5xv7A:
21.15
2a58D-5xv7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 512
HIS A 565
GLY A 525
SER A 526
LEU A 580
 None
 1.26A 2a58D-5xv7A:
undetectable
2a58E-5xv7A:
undetectable		 2a58D-5xv7A:
21.15
2a58E-5xv7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  86
ALA A 107
LYS A 109
GLU A 124
VAL A 145
GLY A 169
LEU A 220
ALA A 496
 EMH  A 705 (-3.9A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
EMH  A 705 ( 4.9A)
EMH  A 705 (-3.5A)
None
EMH  A 705 ( 4.0A)
 1.00A 2zvaA-5xv7A:
23.8		 2zvaA-5xv7A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 PHE A 626
LEU A 630
ALA A 541
ALA A 545
GLU A 622
 None
 1.09A 3cwkA-5xv7A:
undetectable		 3cwkA-5xv7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A 576
LYS A 575
HIS A 599
 None
 0.92A 3elzA-5xv7A:
undetectable		 3elzA-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A 176
ILE A 177
GLU A 217
LYS A 215
TYR A 517
 None
 1.39A 3f78A-5xv7A:
undetectable		 3f78A-5xv7A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  94
ALA A 107
GLU A 124
LEU A 127
LEU A 128
HIS A 211
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
None
 0.87A 3gp0A-5xv7A:
25.4		 3gp0A-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  94
ALA A 107
LYS A 109
GLU A 124
LEU A 128
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
 0.70A 3hegA-5xv7A:
24.7		 3hegA-5xv7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 VAL A 144
ILE A 209
HIS A 211
ILE A 495
 None
 0.40A 3hegA-5xv7A:
24.7		 3hegA-5xv7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 107
GLU A 124
VAL A 145
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
EMH  A 705 ( 4.9A)
None
EMH  A 705 ( 4.0A)
 0.54A 3ik3A-5xv7A:
20.6		 3ik3A-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 GLU A 124
VAL A 145
HIS A 211
LEU A 220
ALA A 496
 None
EMH  A 705 ( 4.9A)
None
None
EMH  A 705 ( 4.0A)
 0.66A 3ik3A-5xv7A:
20.6		 3ik3A-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 107
GLU A 124
VAL A 145
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
EMH  A 705 ( 4.9A)
None
EMH  A 705 ( 4.0A)
 0.52A 3ik3B-5xv7A:
20.5		 3ik3B-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 GLU A 124
VAL A 145
HIS A 211
LEU A 220
ALA A 496
 None
EMH  A 705 ( 4.9A)
None
None
EMH  A 705 ( 4.0A)
 0.62A 3ik3B-5xv7A:
20.5		 3ik3B-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 523
GLY A 525
GLY A 584
ILE A 569
LEU A 636
 None
 1.00A 3nk7B-5xv7A:
undetectable		 3nk7B-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 VAL A  94
ALA A 107
GLU A 124
LEU A 128
PHE A 165
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
EMH  A 705 (-3.6A)
None
None
EMH  A 705 ( 4.0A)
 0.65A 3rgfA-5xv7A:
8.5		 3rgfA-5xv7A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 LEU A 603
ASP A 596
LEU A 597
ILE A 569
LEU A 520
 None
 1.12A 3tqbA-5xv7A:
undetectable		 3tqbA-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 107
LYS A 109
GLU A 124
LEU A 203
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.74A 3zosA-5xv7A:
20.3		 3zosA-5xv7A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 107
LYS A 109
GLU A 124
LEU A 203
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.80A 3zosB-5xv7A:
20.3		 3zosB-5xv7A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 128
ASP A 213
LYS A 215
ASN A 218
ASP A 497
 None
EDO  A 702 ( 4.9A)
None
None
EMH  A 705 (-4.7A)
 0.73A 4an2A-5xv7A:
21.4		 4an2A-5xv7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  86
VAL A  94
ALA A 107
LYS A 109
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.9A)
EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
 0.88A 4asdA-5xv7A:
20.8		 4asdA-5xv7A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 107
LYS A 109
GLU A 124
LEU A 128
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.86A 4c8bA-5xv7A:
20.5		 4c8bA-5xv7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 107
LYS A 109
GLU A 124
LEU A 128
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.88A 4c8bB-5xv7A:
20.5		 4c8bB-5xv7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 VAL A 162
ALA A 121
SER A 154
LEU A  69
VAL A 110
 None
 1.21A 4eilB-5xv7A:
undetectable		 4eilB-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		3 / 3 TRP A 652
GLN A 620
THR A 627
 None
 0.81A 4m2xA-5xv7A:
undetectable		 4m2xA-5xv7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 LEU A  69
ASP A  74
TRP A  95
ILE A  72
 None
 1.46A 4mwrA-5xv7A:
undetectable		 4mwrA-5xv7A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.58A 4v01A-5xv7A:
20.1		 4v01A-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.52A 4v01B-5xv7A:
20.6		 4v01B-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  94
ALA A 107
GLU A 124
HIS A 211
ALA A 496
GLY A 499
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
EMH  A 705 ( 4.0A)
None
 1.33A 4v04A-5xv7A:
20.3		 4v04A-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  94
ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.65A 4v04A-5xv7A:
20.3		 4v04A-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.61A 4v04B-5xv7A:
20.9		 4v04B-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 107
LYS A 109
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
 0.68A 5hi2A-5xv7A:
21.2		 5hi2A-5xv7A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  87
GLY A  89
VAL A  94
LYS A 109
 EMH  A 705 ( 3.9A)
None
EMH  A 705 ( 4.4A)
EMH  A 705 ( 4.8A)
 0.49A 5j5xA-5xv7A:
23.8		 5j5xA-5xv7A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  87
VAL A  94
ALA A 107
VAL A 145
PHE A 165
LEU A 220
ALA A 496
 EMH  A 705 ( 3.9A)
EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.9A)
EMH  A 705 (-3.6A)
None
EMH  A 705 ( 4.0A)
 0.89A 5l2iA-5xv7A:
10.9		 5l2iA-5xv7A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 4 ILE A 524
LEU A 597
HIS A 565
ALA A 567
 None
 0.98A 6ck2C-5xv7A:
undetectable
6ck2D-5xv7A:
undetectable		 6ck2C-5xv7A:
undetectable
6ck2D-5xv7A:
undetectable