SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 12 LEU S 177
ARG S 189
PHE S 185
ILE S 151
PRO S 152
 None
 1.10A 1drfA-5xvdS:
undetectable		 1drfA-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		4 / 6 GLY S  82
ASP S  81
GLY S  24
SER S 119
 8JU  S 404 (-3.7A)
8JU  S 404 ( 2.5A)
8JU  S 404 (-3.7A)
8JU  S 404 ( 4.9A)
 0.98A 1eswA-5xvdS:
undetectable		 1eswA-5xvdS:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 12 ALA S 127
ALA S 129
VAL S  80
ILE S 117
CYH S  25
 None
None
None
None
SF4  S 403 ( 2.1A)
 1.00A 1fm6U-5xvdS:
undetectable		 1fm6U-5xvdS:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 9 GLY S 257
PRO S 152
GLY S 153
GLY S 125
GLY S 124
 F3S  S 402 (-4.4A)
None
None
None
None
 1.06A 1mxdA-5xvdS:
undetectable		 1mxdA-5xvdS:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 11 GLY S 257
PRO S 152
GLY S 153
GLY S 125
GLY S 124
 F3S  S 402 (-4.4A)
None
None
None
None
 1.09A 1mxgA-5xvdS:
undetectable		 1mxgA-5xvdS:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		4 / 6 PHE S 185
ALA S 163
ILE S 149
PRO S 175
 None
 1.21A 1oniH-5xvdS:
undetectable
1oniI-5xvdS:
undetectable		 1oniH-5xvdS:
undetectable
1oniI-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 12 GLY S 118
SER S 119
GLY S 125
VAL S  79
ILE S  17
 8JU  S 404 (-3.6A)
8JU  S 404 ( 4.9A)
None
None
None
 1.16A 2b25B-5xvdS:
undetectable		 2b25B-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		4 / 9 ILE S 191
ALA S 250
VAL S 249
CYH S 226
 None
None
SF4  S 401 ( 4.9A)
SF4  S 401 (-2.3A)
 1.04A 2vufB-5xvdS:
undetectable		 2vufB-5xvdS:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 12 LEU S 177
ARG S 189
PHE S 185
ILE S 151
PRO S 152
 None
 1.10A 2w3bA-5xvdS:
undetectable		 2w3bA-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		3 / 3 HIS S 194
GLU S 193
HIS S 192
 None
None
SF4  S 401 (-3.2A)
 0.83A 3ba0A-5xvdS:
undetectable		 3ba0A-5xvdS:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		5 / 12 LEU S 143
ILE S 100
ILE S 114
ILE S 115
ALA S 121
 None
 1.22A 3uj7A-5xvdS:
undetectable		 3uj7A-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		4 / 8 PHE S 161
LEU S  47
VAL S  14
ILE S 115
 None
 0.93A 4l4cB-5xvdS:
undetectable		 4l4cB-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5xvd HYDROGENASE-2 SMALL
CHAIN
(Citrobacter
sp.
MGH106) 		3 / 3 ARG S 197
ARG S 205
ARG S 198
 None
 1.00A 5vcgA-5xvdS:
undetectable		 5vcgA-5xvdS:
10.90