SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 LEU A 116
GLY A 138
MET A 160
VAL A 158
ALA A 168
 None
 1.12A 1gs4A-5xvhA:
undetectable		 1gs4A-5xvhA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 7 TYR A 159
GLY A 137
ASP A 117
ASP A  99
 None
 1.08A 2g72B-5xvhA:
3.4		 2g72B-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 6 ALA A  67
ASP A  66
GLU A  71
ARG A 107
 None
 1.43A 2ouzA-5xvhA:
undetectable		 2ouzA-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 4 GLY A 164
GLY A 137
GLY A 161
GLY A 166
 None
 0.55A 3bogC-5xvhA:
undetectable		 3bogC-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 4 GLY A 164
GLY A 137
GLY A 161
GLY A 166
 None
 0.53A 3bogD-5xvhA:
undetectable		 3bogD-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		6 / 12 VAL A  80
GLY A  79
GLY A  76
GLU A  82
ALA A  84
ILE A 113
 None
 1.42A 3fuuA-5xvhA:
4.0		 3fuuA-5xvhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 8 PRO A  38
VAL A  44
LEU A  20
LEU A  25
 None
 0.80A 3u5kD-5xvhA:
undetectable		 3u5kD-5xvhA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ARG A 102
VAL A 163
PHE A 115
PHE A 104
SER A  97
 None
 1.27A 4bvaA-5xvhA:
8.1		 4bvaA-5xvhA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ARG A 102
VAL A 163
PHE A 115
PHE A 104
SER A  97
 None
 1.39A 4bvaB-5xvhA:
8.2		 4bvaB-5xvhA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 7 PHE A 104
ASP A  92
SER A  94
SER A  97
 None
None
NAP  A 302 (-4.4A)
None
 1.24A 4lv9A-5xvhA:
2.3
4lv9B-5xvhA:
2.7		 4lv9A-5xvhA:
11.11
4lv9B-5xvhA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ALA A 105
GLY A 164
GLN A 167
ILE A 134
GLU A 114
 None
 1.07A 4r29D-5xvhA:
undetectable		 4r29D-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 LEU A 254
ALA A 257
LEU A 259
LEU A 179
LEU A 236
 None
 0.95A 4xi3C-5xvhA:
undetectable		 4xi3C-5xvhA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 7 ILE A 149
PHE A 150
VAL A  59
ILE A  89
 None
 0.98A 4zzbC-5xvhA:
undetectable
4zzbD-5xvhA:
undetectable		 4zzbC-5xvhA:
undetectable
4zzbD-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 5 VAL A  91
VAL A 136
GLY A 137
PHE A 150
 None
 1.08A 5d4nA-5xvhA:
undetectable
5d4nC-5xvhA:
undetectable		 5d4nA-5xvhA:
undetectable
5d4nC-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN
(Pyrobaculum
calidifontis) 		4 / 7 GLN A 124
GLY A 230
PHE A 231
HIS A 278
 None
None
TLA  A 301 ( 4.1A)
None
 1.02A 6hu9S-5xvhA:
undetectable
6hu9q-5xvhA:
undetectable		 6hu9S-5xvhA:
undetectable
6hu9q-5xvhA:
undetectable