SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 GLY A 375
VAL A 438
ALA A 373
ALA A 377
TYR A 204
 None
 1.23A 2avdA-5xviA:
3.3		 2avdA-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 PHE A 101
VAL A 438
ALA A 373
ALA A 377
TYR A 204
 None
 1.35A 2avdA-5xviA:
3.3		 2avdA-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 GLY A 375
VAL A 438
ALA A 373
ALA A 377
TYR A 204
 None
 1.23A 2avdB-5xviA:
undetectable		 2avdB-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 PHE A 101
VAL A 438
ALA A 373
ALA A 377
TYR A 204
 None
 1.33A 2avdB-5xviA:
undetectable		 2avdB-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 7 LEU A  89
VAL A  68
GLY A  96
ARG A  82
 None
 0.73A 2wd9A-5xviA:
2.1		 2wd9A-5xviA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 8 LEU A  89
VAL A  68
GLY A  96
ARG A  82
 None
 0.70A 2wd9B-5xviA:
2.2		 2wd9B-5xviA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 7 PHE A 166
GLY A 189
LYS A 183
ARG A 396
 None
GOL  A 501 ( 4.2A)
None
None
 1.04A 3aruA-5xviA:
undetectable		 3aruA-5xviA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 9 ARG A  34
ALA A 450
VAL A  40
GLY A 445
ILE A 443
 None
 1.19A 3el4B-5xviA:
undetectable		 3el4B-5xviA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 MET A 208
ILE A 443
GLY A 440
ALA A 423
LEU A 420
 None
 0.97A 3fpjA-5xviA:
3.4		 3fpjA-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 GLY A 381
GLY A 382
VAL A 385
MET A 208
ILE A 192
 None
 0.89A 3h52B-5xviA:
undetectable		 3h52B-5xviA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 7 PHE A 446
GLY A 445
PHE A 101
PHE A  97
 None
 0.98A 3ko0D-5xviA:
undetectable
3ko0E-5xviA:
undetectable		 3ko0D-5xviA:
24.30
3ko0E-5xviA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 8 PHE A  97
PHE A 446
GLY A 445
PHE A 101
 None
 0.94A 3ko0O-5xviA:
0.4
3ko0Q-5xviA:
undetectable		 3ko0O-5xviA:
24.30
3ko0Q-5xviA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 8 ASN A 379
THR A 197
ALA A 384
SER A 386
 None
 1.02A 3kp6A-5xviA:
undetectable		 3kp6A-5xviA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 9 ARG A  34
ALA A 450
VAL A  40
GLY A 445
ILE A 443
 None
 1.22A 3spkA-5xviA:
undetectable		 3spkA-5xviA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 ALA A 342
LEU A 437
GLY A 375
ALA A 384
LEU A 408
 None
 1.20A 3tm4A-5xviA:
5.1		 3tm4A-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 ALA A 342
LEU A 437
GLY A 375
ALA A 384
LEU A 408
 None
 1.21A 3tm4B-5xviA:
undetectable		 3tm4B-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 LEU A  74
THR A 447
ALA A 444
GLY A 419
ALA A 104
 None
 1.14A 4enhA-5xviA:
undetectable		 4enhA-5xviA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 GLY A 115
GLY A  79
VAL A  68
GLN A  99
VAL A  87
 None
 1.18A 4f84A-5xviA:
5.1		 4f84A-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 TYR A 169
CYH A 141
GLN A  69
VAL A 179
LEU A 165
 None
 1.47A 4k38B-5xviA:
undetectable		 4k38B-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 12 PHE A 265
LEU A 272
GLY A 255
ASP A 252
THR A 276
 None
 1.33A 4mubA-5xviA:
undetectable		 4mubA-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 11 ASP A 405
ALA A 236
VAL A 202
TYR A 203
GLY A 198
 None
 1.27A 4xnxA-5xviA:
undetectable		 4xnxA-5xviA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		5 / 10 ASP A 405
ALA A 236
VAL A 202
TYR A 203
GLY A 198
 None
 1.22A 4xp1A-5xviA:
undetectable		 4xp1A-5xviA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5xvi GLUTAMATE
DEHYDROGENASE
(Aspergillus
niger) 		4 / 5 SER A 386
VAL A 383
ASN A 103
PRO A 151
 None
 1.36A 6fi4A-5xviA:
undetectable
6fi4B-5xviA:
undetectable		 6fi4A-5xviA:
undetectable
6fi4B-5xviA:
undetectable