SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 11 PHE A1096
PHE A 947
SER A 943
PHE A 953
VAL A 959
 None
 1.21A 1q23F-5xvmA:
undetectable		 1q23F-5xvmA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 774
THR A 746
SER A 849
MET A 800
 None
 1.17A 1tv8B-5xvmA:
undetectable		 1tv8B-5xvmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 877
PHE A 953
TYR A 940
PHE A1096
HIS A 898
 None
 1.50A 1y7iB-5xvmA:
5.7		 1y7iB-5xvmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A1076
SER A1078
ILE A1087
HIS A1068
 None
 1.17A 1yajJ-5xvmA:
2.3		 1yajJ-5xvmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 774
THR A 746
SER A 849
MET A 800
 None
 1.16A 2fb2B-5xvmA:
undetectable		 2fb2B-5xvmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 744
ILE A 843
LEU A1159
ILE A 845
PHE A 742
 None
 1.04A 2ygqA-5xvmA:
undetectable		 2ygqA-5xvmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 790
ARG A 779
ARG A 838
GLU A 834
 None
 1.15A 2zt7A-5xvmA:
2.3		 2zt7A-5xvmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 11 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
 None
 1.15A 3a51A-5xvmA:
undetectable		 3a51A-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
 None
 1.11A 3a51C-5xvmA:
undetectable		 3a51C-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
 None
 1.08A 3a51D-5xvmA:
undetectable		 3a51D-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
 None
 1.08A 3a51E-5xvmA:
undetectable		 3a51E-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.12A 3eeyA-5xvmA:
3.5		 3eeyA-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.14A 3eeyB-5xvmA:
2.4		 3eeyB-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.12A 3eeyF-5xvmA:
undetectable		 3eeyF-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.13A 3eeyH-5xvmA:
3.6		 3eeyH-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A1085
GLY A1107
ASN A1128
GLY A1070
HIS A1068
 None
 1.14A 3eeyI-5xvmA:
3.0		 3eeyI-5xvmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 743
TYR A1156
LEU A1159
ILE A 862
LEU A 759
 None
 0.93A 3g9eA-5xvmA:
undetectable		 3g9eA-5xvmA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 740
GLU A1158
TYR A1161
 None
 0.90A 3ug8A-5xvmA:
undetectable		 3ug8A-5xvmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1079
ALA A1077
THR A1085
PHE A1060
 None
 1.23A 3vasB-5xvmA:
undetectable		 3vasB-5xvmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 940
VAL A 959
PHE A 953
ILE A 946
 None
 0.85A 3zjqA-5xvmA:
undetectable		 3zjqA-5xvmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 940
VAL A 959
PHE A 953
ILE A 946
 None
 0.88A 3zjqB-5xvmA:
undetectable		 3zjqB-5xvmA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 762
LEU A 763
ILE A 764
ILE A 787
 None
 0.86A 4em2A-5xvmA:
1.7		 4em2A-5xvmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 991
LEU A1083
ARG A 985
ILE A 981
GLN A 978
 None
 1.16A 4f4dA-5xvmA:
1.5		 4f4dA-5xvmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1096
TYR A 878
PRO A 949
PHE A 953
 None
 1.14A 4grqA-5xvmA:
undetectable
4grqC-5xvmA:
undetectable		 4grqA-5xvmA:
17.49
4grqC-5xvmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1001
SER A1029
TRP A1028
 None
 0.95A 5jwaA-5xvmA:
3.3		 5jwaA-5xvmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 990
ASP A1019
ILE A 981
 None
 0.90A 5kc4E-5xvmA:
undetectable		 5kc4E-5xvmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1159
ARG A 958
ILE A1155
PHE A 865
 None
 1.23A 5kirB-5xvmA:
undetectable		 5kirB-5xvmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 880
GLU A 902
TRP A 872
 None
 1.10A 5odiD-5xvmA:
3.4		 5odiD-5xvmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 880
GLU A 902
TRP A 872
 None
 1.14A 5odqD-5xvmA:
3.5		 5odqD-5xvmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 880
GLU A 902
TRP A 872
 None
 1.09A 5odrD-5xvmA:
3.3		 5odrD-5xvmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 743
TYR A1156
LEU A1159
ILE A 862
LEU A 759
 None
 0.73A 5ycnA-5xvmA:
undetectable		 5ycnA-5xvmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		5 / 9 ASN A 941
ILE A 757
GLU A 777
VAL A 782
ILE A 787
 None
 1.33A 6hloA-5xvmA:
5.8		 6hloA-5xvmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1093
SER A 847
SER A 849
 None
 0.62A 6mxtA-5xvmA:
undetectable		 6mxtA-5xvmA:
21.97