SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		3 / 3 ASP A 216
LEU A 200
LEU A 213
 None
 0.68A 1ikeA-5xvnA:
undetectable		 1ikeA-5xvnA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		4 / 8 ASP A 216
PHE A 211
ASN A 212
MET A 218
 None
 1.10A 1lhvA-5xvnA:
undetectable		 1lhvA-5xvnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		3 / 3 ASP A 216
LEU A 200
LEU A 213
 None
 0.72A 1np1B-5xvnA:
undetectable		 1np1B-5xvnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		5 / 12 VAL A   6
ILE A  37
ILE A  62
VAL A   8
LEU A  42
 None
 0.89A 1qhsA-5xvnA:
undetectable		 1qhsA-5xvnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		5 / 12 VAL A   6
ILE A  37
ILE A  62
VAL A   8
LEU A  42
 None
 0.93A 1qhyA-5xvnA:
undetectable		 1qhyA-5xvnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		4 / 6 PHE A 156
PHE A 164
GLY A 175
ASN A 170
 None
 0.89A 2qr2A-5xvnA:
undetectable
2qr2B-5xvnA:
undetectable		 2qr2A-5xvnA:
22.11
2qr2B-5xvnA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		4 / 8 GLY A 175
ASN A 177
PHE A 156
TYR A 180
 None
 1.26A 3ccfA-5xvnA:
undetectable		 3ccfA-5xvnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		5 / 12 GLN A  93
LEU A 202
LEU A 217
LEU A 276
ARG A 100
 None
 1.04A 3fsuA-5xvnA:
undetectable		 3fsuA-5xvnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5xvn CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS2
(Enterococcus
faecalis) 		3 / 3 ASN E  55
ALA E  54
LYS E  56
 None
 0.98A 3runA-5xvnE:
undetectable		 3runA-5xvnE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		3 / 3 GLY A 179
THR A 181
ASN A 177
 None
 0.72A 3v4tD-5xvnA:
undetectable		 3v4tD-5xvnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		4 / 8 PHE A 156
PHE A 164
GLY A 175
ASN A 170
 None
 0.89A 4fgjA-5xvnA:
undetectable
4fgjB-5xvnA:
undetectable		 4fgjA-5xvnA:
22.37
4fgjB-5xvnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		4 / 8 PHE A 156
PHE A 164
GLY A 175
ASN A 170
 None
 0.91A 4qoiA-5xvnA:
undetectable
4qoiB-5xvnA:
undetectable		 4qoiA-5xvnA:
22.37
4qoiB-5xvnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		4 / 7 LEU A  57
ARG A  56
LEU A  53
LEU A  40
 None
 0.81A 4wg0L-5xvnA:
undetectable
4wg0M-5xvnA:
undetectable		 4wg0L-5xvnA:
4.10
4wg0M-5xvnA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1
(Enterococcus
faecalis) 		5 / 12 LEU A 247
PHE A 286
ALA A 265
THR A 269
ALA A 214
 None
 1.05A 5veuB-5xvnA:
undetectable		 5veuB-5xvnA:
22.59