SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 PRO A 137
THR A  66
GLY A  65
GLY A  64
THR A  62
 None
 1.08A 2uvnA-5xw3A:
undetectable		 2uvnA-5xw3A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ILE A  77
GLY A  48
ALA A  80
ASP A  45
VAL A  43
 None
 1.14A 2yvlB-5xw3A:
undetectable		 2yvlB-5xw3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ILE A  77
GLY A  48
ALA A  80
ASP A  45
VAL A  43
 None
 1.23A 2yvlC-5xw3A:
3.2		 2yvlC-5xw3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ILE A  77
GLY A  48
ALA A  80
ASP A  45
VAL A  43
 None
 1.11A 2yvlD-5xw3A:
3.4		 2yvlD-5xw3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		4 / 8 GLY A 180
GLY A 181
GLY A 176
ILE A 201
 None
 0.70A 3d41A-5xw3A:
undetectable		 3d41A-5xw3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 10 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
 None
 1.25A 3lxiA-5xw3A:
undetectable		 3lxiA-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 11 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
 None
 1.27A 3lxiB-5xw3A:
undetectable		 3lxiB-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ASP A 237
GLY A 185
ALA A 187
PHE A 173
ALA A 175
 None
 1.05A 3sudA-5xw3A:
undetectable		 3sudA-5xw3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ASP A 237
GLY A 185
ALA A 187
PHE A 173
ALA A 175
 None
 1.04A 3sudD-5xw3A:
undetectable		 3sudD-5xw3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ASP A 237
GLY A 185
ALA A 187
PHE A 173
ALA A 175
 None
 1.02A 3sugA-5xw3A:
undetectable		 3sugA-5xw3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ALA A  83
ILE A  67
GLY A  48
VAL A  92
VAL A  90
 None
 0.91A 3ucbB-5xw3A:
undetectable		 3ucbB-5xw3A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 9 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
 None
 1.22A 4c9pA-5xw3A:
undetectable		 4c9pA-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 10 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
 None
 1.23A 4c9pB-5xw3A:
undetectable		 4c9pB-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 10 ALA A  83
ILE A  67
GLY A  48
VAL A  92
VAL A  90
 None
 0.93A 4j5jB-5xw3A:
undetectable		 4j5jB-5xw3A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 ASP A 292
ALA A 177
PHE A 290
GLY A 180
THR A 288
 None
 1.31A 4mm4A-5xw3A:
undetectable		 4mm4A-5xw3A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		3 / 3 ASP A  45
GLU A  69
SER A 293
 None
 0.84A 5bw4B-5xw3A:
undetectable		 5bw4B-5xw3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 LEU A  24
LEU A 274
ALA A 277
LEU A 166
ILE A  19
 None
 1.13A 5ljeA-5xw3A:
undetectable		 5ljeA-5xw3A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5xw3 O-ACETYLSERINE LYASE
(Bacillus
anthracis) 		5 / 12 GLY A  48
ASN A 150
ALA A 153
LEU A  79
PRO A  70
 None
 1.17A 6b3bA-5xw3A:
3.1		 6b3bA-5xw3A:
20.47