SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 185
THR A 301
VAL A 266
GLY A 267
ASP A 184
 None
 1.47A 1dz8B-5xw5A:
undetectable		 1dz8B-5xw5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 185
THR A 301
VAL A 266
GLY A 267
ASP A 184
 None
 1.46A 1dz9B-5xw5A:
undetectable		 1dz9B-5xw5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 177
LYS A 284
ARG A 289
 None
 1.13A 1ra8A-5xw5A:
undetectable		 1ra8A-5xw5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 139
ASP A  50
PHE A  51
 None
 0.39A 1uwjB-5xw5A:
undetectable		 1uwjB-5xw5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 352
GLY A 267
SER A 260
LEU A 359
LEU A 249
 None
 0.95A 1ya4A-5xw5A:
undetectable		 1ya4A-5xw5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 185
THR A 301
VAL A 266
GLY A 267
ASP A 184
 None
 1.40A 2a1mA-5xw5A:
undetectable		 2a1mA-5xw5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 185
THR A 301
GLY A 267
ASP A 184
 None
 0.88A 2a1oA-5xw5A:
undetectable		 2a1oA-5xw5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 247
LEU A 356
ILE A 242
VAL A 223
ILE A 279
 None
 1.06A 2uxoB-5xw5A:
undetectable		 2uxoB-5xw5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		3 / 3 MET A  54
MET A 320
PHE A  51
 None
 1.32A 3gn8A-5xw5A:
undetectable		 3gn8A-5xw5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  96
PRO A 126
ASP A 143
 None
 1.01A 3hlwB-5xw5A:
undetectable		 3hlwB-5xw5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 128
PRO A  53
PHE A  51
 None
 1.00A 3thrC-5xw5A:
undetectable		 3thrC-5xw5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 159
LYS A 152
VAL A 148
TYR A 101
 None
 1.14A 4b3qA-5xw5A:
undetectable		 4b3qA-5xw5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		6 / 12 PHE A 127
GLN A  90
ALA A  94
ALA A  92
ALA A  95
VAL A 145
 None
 1.37A 4jbtA-5xw5A:
undetectable		 4jbtA-5xw5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 128
GLY A 131
ALA A 130
GLY A 323
 None
 0.92A 4u9uA-5xw5A:
undetectable		 4u9uA-5xw5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 227
GLN A 245
GLY A 277
GLY A 276
ILE A 273
 None
 1.24A 4zvmA-5xw5A:
undetectable
4zvmB-5xw5A:
undetectable		 4zvmA-5xw5A:
19.66
4zvmB-5xw5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 304
LEU A 156
THR A 182
THR A 305
GLU A 270
 None
 1.44A 5v1tA-5xw5A:
undetectable		 5v1tA-5xw5A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 148
GLU A 171
VAL A  38
PHE A 315
ILE A  65
 None
 1.37A 6becA-5xw5A:
undetectable
6becB-5xw5A:
undetectable
6becC-5xw5A:
undetectable		 6becA-5xw5A:
23.40
6becB-5xw5A:
23.40
6becC-5xw5A:
23.40