SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 6 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 1.04A 1iepA-5xw6C:
undetectable		 1iepA-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		5 / 10 ILE C  82
LEU C  65
VAL C  63
VAL C 178
LEU C 219
 None
None
None
128  C 502 (-4.7A)
None
 0.89A 3gwxA-5xw6C:
undetectable		 3gwxA-5xw6C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 8 GLY C 237
PHE C 217
PHE C 304
PHE C  90
 None
 0.95A 3ko0D-5xw6C:
undetectable
3ko0E-5xw6C:
undetectable		 3ko0D-5xw6C:
13.15
3ko0E-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 8 PHE C 304
PHE C  90
GLY C 237
PHE C 217
 None
 0.88A 3ko0B-5xw6C:
undetectable
3ko0J-5xw6C:
undetectable		 3ko0B-5xw6C:
13.15
3ko0J-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 8 GLY C 237
PHE C 217
PHE C 304
PHE C  90
 None
 0.94A 3ko0K-5xw6C:
undetectable
3ko0S-5xw6C:
undetectable		 3ko0K-5xw6C:
13.15
3ko0S-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 7 GLY C 237
PHE C 217
PHE C 304
PHE C  90
 None
 0.84A 3ko0M-5xw6C:
undetectable
3ko0P-5xw6C:
undetectable		 3ko0M-5xw6C:
13.15
3ko0P-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 7 PHE C 304
PHE C  90
GLY C 237
PHE C 217
 None
 0.87A 3ko0K-5xw6C:
undetectable
3ko0S-5xw6C:
undetectable		 3ko0K-5xw6C:
13.15
3ko0S-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 7 PHE C 304
PHE C  90
GLY C 237
PHE C 217
 None
 0.96A 3ko0R-5xw6C:
undetectable
3ko0T-5xw6C:
undetectable		 3ko0R-5xw6C:
13.15
3ko0T-5xw6C:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 6 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.73A 3ms9A-5xw6C:
undetectable		 3ms9A-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 7 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.81A 3ms9B-5xw6C:
undetectable		 3ms9B-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 6 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.73A 3mssA-5xw6C:
undetectable		 3mssA-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 7 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 1.07A 3mssB-5xw6C:
undetectable		 3mssB-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 6 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.74A 3mssC-5xw6C:
undetectable		 3mssC-5xw6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 6 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.81A 3pyyA-5xw6C:
undetectable		 3pyyA-5xw6C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		5 / 11 VAL C  61
VAL C  63
PHE C  90
ILE C 222
PHE C 217
 None
 1.04A 5e4dB-5xw6C:
undetectable		 5e4dB-5xw6C:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		4 / 8 ILE C 196
GLN C 194
THR C 192
SER C  59
 None
 1.02A 6c06C-5xw6C:
undetectable		 6c06C-5xw6C:
undetectable