SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 9 TYR A  82
PHE A 104
GLY A 141
ASP A 180
MET A 254
ASP A 257
TRP A 425
None
0.93A 1e9lA-5xwqA:
38.1
1e9lA-5xwqA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 9 TYR A  82
PHE A 104
GLY A 141
ASP A 180
MET A 254
TYR A 256
ASP A 257
None
0.77A 1e9lA-5xwqA:
38.1
1e9lA-5xwqA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 6 PRO A 236
ASP A 241
ASN A 243
ASP A 242
None
1.47A 1hpkA-5xwqA:
undetectable
1hpkA-5xwqA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 7 ASP A 180
VAL A 101
GLY A 306
ILE A 253
None
0.82A 1t7jB-5xwqA:
undetectable
1t7jB-5xwqA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 12 LEU A 437
LEU A 424
ALA A  81
ILE A 100
ASP A 430
None
1.03A 1tw4A-5xwqA:
undetectable
1tw4A-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 4 SER A 385
ILE A 384
VAL A 281
THR A 316
None
1.11A 1u70A-5xwqA:
undetectable
1u70A-5xwqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 6 TYR A 389
SER A 323
ALA A 322
THR A 324
None
1.08A 1yvpB-5xwqA:
undetectable
1yvpB-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 11 TYR A  82
PHE A 104
GLY A 141
ASP A 180
MET A 254
TYR A 256
TYR A 310
TRP A 425
None
0.83A 2a3aA-5xwqA:
10.6
2a3aA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
9 / 11 TYR A  82
PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.48A 2a3aA-5xwqA:
10.6
2a3aA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 11 TYR A  82
PHE A 104
GLY A 141
TRP A 142
GLU A 182
MET A 254
TYR A 256
TRP A 425
None
0.58A 2a3aA-5xwqA:
10.6
2a3aA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
3 / 3 TRP A 142
GLU A 182
TYR A 183
None
0.38A 2a3aA-5xwqA:
10.6
2a3aA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 9 PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.45A 2a3aB-5xwqA:
10.0
2a3aB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 11 TYR A  82
PHE A 104
GLY A 141
ASP A 180
TYR A 256
TYR A 310
TRP A 425
None
0.92A 2a3bA-5xwqA:
36.1
2a3bA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 11 TYR A  82
PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
TRP A 425
None
0.82A 2a3bA-5xwqA:
36.1
2a3bA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 11 TYR A  82
PHE A 104
GLY A 141
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.50A 2a3bA-5xwqA:
36.1
2a3bA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 10 PHE A 104
GLY A 141
ASP A 180
GLU A 182
MET A 254
TYR A 256
TRP A 425
None
1.00A 2a3bB-5xwqA:
10.5
2a3bB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 10 PHE A 104
GLY A 141
ASP A 180
MET A 254
TYR A 256
TYR A 310
TRP A 425
None
0.84A 2a3bB-5xwqA:
10.5
2a3bB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 10 PHE A 104
GLY A 141
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.37A 2a3bB-5xwqA:
10.5
2a3bB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 12 TYR A  82
TRP A  86
PHE A 104
GLY A 141
ASP A 180
GLU A 182
TYR A 256
TRP A 425
None
1.05A 2a3cA-5xwqA:
10.6
2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 12 TYR A  82
TRP A  86
PHE A 104
GLY A 141
ASP A 180
TYR A 256
TYR A 310
TRP A 425
None
0.89A 2a3cA-5xwqA:
10.6
2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 12 TYR A  82
TRP A  86
PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
TRP A 425
None
0.81A 2a3cA-5xwqA:
10.6
2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
9 / 12 TYR A  82
TRP A  86
PHE A 104
GLY A 141
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.48A 2a3cA-5xwqA:
10.6
2a3cA-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 12 TRP A  86
PHE A 104
GLY A 141
ASP A 180
GLU A 182
MET A 254
TYR A 256
TRP A 425
None
0.98A 2a3cB-5xwqA:
10.0
2a3cB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 12 TRP A  86
PHE A 104
GLY A 141
ASP A 180
MET A 254
TYR A 256
TYR A 310
TRP A 425
None
0.81A 2a3cB-5xwqA:
10.0
2a3cB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 12 TRP A  86
PHE A 104
GLY A 141
THR A 143
GLU A 182
MET A 254
TYR A 256
TRP A 425
None
0.74A 2a3cB-5xwqA:
10.0
2a3cB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
9 / 12 TRP A  86
PHE A 104
GLY A 141
THR A 143
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.45A 2a3cB-5xwqA:
10.0
2a3cB-5xwqA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 12 PRO A 184
GLY A 141
PHE A 148
ALA A 223
TYR A 203
None
1.42A 2axnA-5xwqA:
2.1
2axnA-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
3 / 3 LYS A 410
ASP A 339
ASP A 402
None
0.87A 2br4D-5xwqA:
undetectable
2br4D-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 9 TYR A  82
PHE A 104
GLY A 141
ASP A 180
GLU A 182
TYR A 256
TRP A 425
None
0.48A 2uy4A-5xwqA:
17.8
2uy4A-5xwqA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 11 TYR A  82
PHE A 104
GLY A 141
ASP A 180
GLU A 182
TYR A 256
TRP A 425
None
0.76A 2xtkA-5xwqA:
17.8
2xtkA-5xwqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 10 TYR A  82
PHE A 104
GLY A 141
ASP A 180
GLU A 182
TYR A 256
TRP A 425
None
0.61A 2xtkB-5xwqA:
18.1
2xtkB-5xwqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 8 THR A 387
ASP A 382
TYR A 413
TYR A 273
None
1.18A 2xz5A-5xwqA:
undetectable
2xz5C-5xwqA:
undetectable
2xz5A-5xwqA:
undetectable
2xz5C-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 10 TYR A 256
ARG A 312
GLU A 428
GLY A 311
GLN A 359
None
1.35A 2z71A-5xwqA:
undetectable
2z71C-5xwqA:
undetectable
2z71A-5xwqA:
14.03
2z71C-5xwqA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 11 PHE A 104
GLY A 141
TRP A 142
ASP A 180
TYR A 256
TYR A 310
TRP A 425
None
0.91A 3g6mA-5xwqA:
36.7
3g6mA-5xwqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
8 / 11 PHE A 104
GLY A 141
TRP A 142
GLU A 182
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.64A 3g6mA-5xwqA:
36.7
3g6mA-5xwqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 11 TYR A  82
PHE A 104
GLY A 141
ASP A 180
TYR A 256
TYR A 310
TRP A 425
None
0.94A 3g6mA-5xwqA:
36.7
3g6mA-5xwqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
9 / 11 TYR A  82
PHE A 104
GLY A 141
GLU A 182
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.57A 3g6mA-5xwqA:
36.7
3g6mA-5xwqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 6 TYR A 203
ASN A 178
LEU A 179
ASP A 180
None
1.43A 3lslG-5xwqA:
undetectable
3lslG-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 PHE A 116
LEU A 113
ASP A 118
GLU A 171
LEU A 137
None
None
MG  A 501 (-2.6A)
MG  A 501 (-4.2A)
None
1.39A 3o94A-5xwqA:
undetectable
3o94A-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 PHE A 116
LEU A 113
ASP A 118
GLU A 171
LEU A 137
None
None
MG  A 501 (-2.6A)
MG  A 501 (-4.2A)
None
1.40A 3o94B-5xwqA:
undetectable
3o94B-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 PHE A 116
LEU A 113
ASP A 118
GLU A 171
LEU A 137
None
None
MG  A 501 (-2.6A)
MG  A 501 (-4.2A)
None
1.40A 3o94C-5xwqA:
undetectable
3o94C-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 PHE A 116
LEU A 113
ASP A 118
GLU A 171
LEU A 137
None
None
MG  A 501 (-2.6A)
MG  A 501 (-4.2A)
None
1.39A 3o94D-5xwqA:
undetectable
3o94D-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 GLU A 182
MET A 254
TYR A 256
ASP A 257
ARG A 312
None
0.97A 3wqvA-5xwqA:
40.4
3wqvA-5xwqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
10 / 11 PHE A 104
GLY A 141
TRP A 142
ASP A 180
GLU A 182
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.44A 3wqvA-5xwqA:
40.4
3wqvA-5xwqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 GLU A 182
MET A 254
TYR A 256
ASP A 257
ARG A 312
None
1.00A 3wqwA-5xwqA:
40.4
3wqwA-5xwqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
10 / 11 PHE A 104
GLY A 141
TRP A 142
ASP A 180
GLU A 182
MET A 254
TYR A 256
ASP A 257
TYR A 310
TRP A 425
None
0.47A 3wqwA-5xwqA:
40.4
3wqwA-5xwqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 5 LEU A 305
GLY A 286
THR A 284
VAL A 258
None
1.04A 3wrkD-5xwqA:
undetectable
3wrkD-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
3 / 3 ALA A 390
TRP A 377
VAL A 378
None
0.24A 4w9nC-5xwqA:
undetectable
4w9nC-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 11 LEU A 179
GLU A 212
LEU A 210
LEU A 206
TYR A 203
None
0.89A 4wg0H-5xwqA:
undetectable
4wg0I-5xwqA:
undetectable
4wg0J-5xwqA:
undetectable
4wg0H-5xwqA:
undetectable
4wg0I-5xwqA:
undetectable
4wg0J-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 12 VAL A 278
GLY A 267
ALA A 268
ILE A 384
THR A 387
None
1.02A 4xdrA-5xwqA:
undetectable
4xdrA-5xwqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
3 / 3 TRP A 142
GLU A 182
ASP A 257
None
0.23A 5gqbA-5xwqA:
37.3
5gqbA-5xwqA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
7 / 8 PHE A 104
GLY A 141
TRP A 142
GLU A 182
TYR A 256
ASP A 257
TRP A 425
None
0.36A 5gqbA-5xwqA:
37.2
5gqbA-5xwqA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 10 ILE A 365
ASP A 402
LEU A 407
THR A 435
THR A 341
None
1.32A 6b4yA-5xwqA:
undetectable
6b4yA-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 10 GLY A 176
LEU A 174
VAL A 124
ALA A 128
LEU A 121
None
1.02A 6czmA-5xwqA:
undetectable
6czmC-5xwqA:
undetectable
6czmA-5xwqA:
undetectable
6czmC-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
4 / 6 ILE A 320
TYR A 389
VAL A 328
SER A 323
None
1.27A 6f6jA-5xwqA:
undetectable
6f6jA-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei)
5 / 10 ASP A 180
GLY A 140
GLY A 144
GLU A 106
PHE A 161
None
1.16A 6nqaK-5xwqA:
undetectable
6nqaK-5xwqA:
undetectable