SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xwu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 4 VAL B 104
ALA B 108
LEU B 112
PHE B  85
 None
 1.26A 1q97B-5xwuB:
undetectable		 1q97B-5xwuB:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 4 LEU B  56
PRO B  60
LEU B  72
ARG B  71
 None
 1.32A 2hrcA-5xwuB:
undetectable		 2hrcA-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		5 / 12 LEU B 167
PHE B 157
LEU B 188
MET B 185
ILE B 149
 None
 1.20A 2hrcB-5xwuB:
undetectable		 2hrcB-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 8 ILE B 101
LEU B  72
LEU B  70
PHE B 109
 None
 0.80A 2vctA-5xwuB:
undetectable		 2vctA-5xwuB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 8 ILE B 149
LEU B 120
LEU B 118
PHE B 157
 None
 0.77A 2vctA-5xwuB:
undetectable		 2vctA-5xwuB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 8 ILE B 149
LEU B 120
LEU B 118
PHE B 157
 None
 0.81A 2vctB-5xwuB:
undetectable		 2vctB-5xwuB:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 0.95A 2y69P-5xwuB:
undetectable
2y69W-5xwuB:
undetectable		 2y69P-5xwuB:
undetectable
2y69W-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 LYS B 224
PRO B 227
TRP B 179
GLU B 203
 None
 1.30A 4a7tA-5xwuB:
undetectable		 4a7tA-5xwuB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 LYS B 224
PRO B 227
TRP B 179
GLU B 203
 None
 1.40A 4a7uA-5xwuB:
undetectable		 4a7uA-5xwuB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 ILE B  77
ARG B  98
ASP B 121
VAL B 104
 None
 1.26A 4nkxD-5xwuB:
undetectable		 4nkxD-5xwuB:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 7 GLN B 132
VAL B 104
PHE B 109
LEU B 120
 None
 0.84A 5m78A-5xwuB:
undetectable		 5m78A-5xwuB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 8 ALA B 156
PHE B 109
LEU B 136
VAL B 104
 None
 0.62A 5nujA-5xwuB:
undetectable		 5nujA-5xwuB:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.01A 5xdqC-5xwuB:
undetectable
5xdqJ-5xwuB:
undetectable		 5xdqC-5xwuB:
undetectable
5xdqJ-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.03A 5xdqP-5xwuB:
undetectable
5xdqW-5xwuB:
undetectable		 5xdqP-5xwuB:
undetectable
5xdqW-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 0.99A 5z84P-5xwuB:
undetectable
5z84W-5xwuB:
undetectable		 5z84P-5xwuB:
undetectable
5z84W-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.03A 5z85P-5xwuB:
undetectable
5z85W-5xwuB:
undetectable		 5z85P-5xwuB:
undetectable
5z85W-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.05A 5z86C-5xwuB:
undetectable
5z86J-5xwuB:
undetectable		 5z86C-5xwuB:
undetectable
5z86J-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.00A 5z86P-5xwuB:
undetectable
5z86W-5xwuB:
undetectable		 5z86P-5xwuB:
undetectable
5z86W-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 0.97A 5zcoP-5xwuB:
undetectable
5zcoW-5xwuB:
undetectable		 5zcoP-5xwuB:
undetectable
5zcoW-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.04A 5zcpC-5xwuB:
undetectable
5zcpJ-5xwuB:
undetectable		 5zcpC-5xwuB:
undetectable
5zcpJ-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 6 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 0.98A 5zcpP-5xwuB:
undetectable
5zcpW-5xwuB:
undetectable		 5zcpP-5xwuB:
undetectable
5zcpW-5xwuB:
undetectable