SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 LEU A1093
LEU A1115
LEU A1065
ILE A1057
MET A 867
None
1.06A 1crbA-5xwyA:
undetectable
1crbA-5xwyA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 6 VAL A 385
ASN A 776
ILE A 379
ASN A 378
None
A  B  32 ( 4.2A)
None
None
0.89A 1e06A-5xwyA:
undetectable
1e06A-5xwyA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 ARG A 185
ASP A1044
ASN A1070
SER A1076
None
1.24A 1kiaB-5xwyA:
undetectable
1kiaB-5xwyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 6 ARG A 185
ASP A1044
ASN A1070
SER A1076
None
1.26A 1kiaC-5xwyA:
undetectable
1kiaC-5xwyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 10 GLY A 168
VAL A 166
ALA A 153
ALA A 361
ILE A 360
None
1.09A 1likA-5xwyA:
undetectable
1likA-5xwyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 ARG A 185
ASP A1044
ASN A1070
SER A1076
None
1.26A 1nbhB-5xwyA:
0.0
1nbhB-5xwyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 PHE A 616
SER A 619
ILE A 622
PHE A 680
ILE A 658
None
1.39A 1ot7A-5xwyA:
undetectable
1ot7A-5xwyA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 ILE A 320
LEU A 329
PHE A 324
LEU A 304
ILE A 212
None
1.11A 1rb2B-5xwyA:
undetectable
1rb2B-5xwyA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 LYS A   2
ASP A 670
ASN A 668
None
0.89A 2bm9A-5xwyA:
undetectable
2bm9A-5xwyA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 LEU A 312
LYS A 321
PHE A 324
ILE A 223
LEU A 208
None
1.07A 2oipE-5xwyA:
undetectable
2oipE-5xwyA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 SER A 265
GLU A 297
ASP A 236
None
A  B  12 ( 2.6A)
U  B  16 ( 3.8A)
0.78A 2zthA-5xwyA:
undetectable
2zthA-5xwyA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 ASN A1136
GLY A 955
TYR A1096
ASN A 861
PHE A 824
None
1.48A 3a27A-5xwyA:
undetectable
3a27A-5xwyA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 10 GLU A 506
ALA A 462
PHE A 460
PHE A 449
LEU A 441
None
1.22A 3a3yA-5xwyA:
undetectable
3a3yA-5xwyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 11 ILE A 563
LEU A 699
ASN A 695
ILE A 702
LEU A 596
None
1.31A 3a50C-5xwyA:
2.7
3a50C-5xwyA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 SER A 265
GLU A 297
ASP A 236
None
A  B  12 ( 2.6A)
U  B  16 ( 3.8A)
0.67A 3bwmA-5xwyA:
undetectable
3bwmA-5xwyA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 SER A 265
GLU A 297
ASP A 236
None
A  B  12 ( 2.6A)
U  B  16 ( 3.8A)
0.68A 3bwyA-5xwyA:
undetectable
3bwyA-5xwyA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 GLY A   8
SER A  10
ASP A 645
ILE A 646
LEU A 661
None
G  B  23 ( 3.6A)
None
None
None
1.33A 3iv6B-5xwyA:
undetectable
3iv6B-5xwyA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 ASN A 250
ASN A 252
GLU A 256
None
0.93A 3kpdC-5xwyA:
undetectable
3kpdC-5xwyA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 ASN A 250
ASN A 252
GLU A 256
None
0.88A 3kpdB-5xwyA:
undetectable
3kpdB-5xwyA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 7 LEU A 766
ARG A 758
ILE A 487
PHE A 488
None
0.89A 3ln1C-5xwyA:
undetectable
3ln1C-5xwyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 LEU A 766
ARG A 758
ILE A 487
PHE A 488
None
0.91A 3ln1D-5xwyA:
undetectable
3ln1D-5xwyA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 7 ASN A 598
LEU A 701
LEU A 520
PHE A 543
None
1.07A 3nk2X-5xwyA:
undetectable
3nk2X-5xwyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 9 PHE A 517
PHE A 721
ASN A 741
ILE A 740
PHE A 526
None
1.43A 3t3rC-5xwyA:
undetectable
3t3rC-5xwyA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 6 GLU A 424
GLY A 423
LEU A 394
GLU A 458
None
1.16A 3w9tB-5xwyA:
undetectable
3w9tB-5xwyA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 6 GLU A 424
GLY A 423
LEU A 394
GLU A 458
None
1.16A 3w9tE-5xwyA:
undetectable
3w9tE-5xwyA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 9 LEU A 596
ILE A 550
ILE A 681
TYR A 560
ILE A 684
None
1.09A 3zosB-5xwyA:
undetectable
3zosB-5xwyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 HIS A1122
HIS A 908
GLN A 904
TYR A 928
C  B  38 ( 3.6A)
A  B  40 ( 4.1A)
C  B  38 ( 3.8A)
None
0.97A 4gboB-5xwyA:
undetectable
4gboB-5xwyA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 ASP A 364
THR A 362
GLU A  17
ASN A 151
VAL A  21
None
None
None
C  B   9 ( 3.2A)
None
1.46A 4njgA-5xwyA:
undetectable
4njgA-5xwyA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 ASN A 347
ASP A 342
ASP A 974
ILE A 970
ASN A 339
U  B  26 ( 4.4A)
None
None
None
C  B   8 ( 3.5A)
1.34A 4pooB-5xwyA:
undetectable
4pooB-5xwyA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 6 ASN A 606
GLU A 603
TYR A 601
GLU A 544
None
None
C  B  33 ( 3.8A)
None
1.38A 4r87H-5xwyA:
undetectable
4r87H-5xwyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 6 ASN A 934
GLU A 936
TYR A 938
GLU A 937
None
1.29A 4r87H-5xwyA:
undetectable
4r87H-5xwyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 ASP A 459
VAL A 425
ASP A 426
GLY A 408
None
1.00A 4xp6A-5xwyA:
0.0
4xp6A-5xwyA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 SER A 265
GLU A 297
ASP A 236
None
A  B  12 ( 2.6A)
U  B  16 ( 3.8A)
0.70A 4xudA-5xwyA:
undetectable
4xudA-5xwyA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
5 / 12 LEU A 769
LEU A 766
PHE A 490
PHE A 488
LEU A 781
None
1.21A 5iepA-5xwyA:
undetectable
5iepA-5xwyA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 7 SER A 265
GLU A 297
ARG A 224
ASP A 236
None
A  B  12 ( 2.6A)
A  B  19 ( 3.2A)
U  B  16 ( 3.8A)
0.92A 5n5dB-5xwyA:
undetectable
5n5dB-5xwyA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 LYS A 207
GLU A 211
GLU A 229
PHE A 226
None
1.28A 5onlA-5xwyA:
undetectable
5onlA-5xwyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 4 HIS A1122
HIS A 908
GLN A 904
TYR A 928
C  B  38 ( 3.6A)
A  B  40 ( 4.1A)
C  B  38 ( 3.8A)
None
0.95A 5uizB-5xwyA:
undetectable
5uizB-5xwyA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 9 ILE A 487
TYR A 784
ILE A 800
LEU A 799
None
0.82A 5vkqB-5xwyA:
undetectable
5vkqC-5xwyA:
undetectable
5vkqB-5xwyA:
20.99
5vkqC-5xwyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 8 PHE A 478
ILE A 487
PHE A 375
ASN A 372
None
1.01A 5x23A-5xwyA:
undetectable
5x23A-5xwyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 SER A 182
HIS A1020
TYR A1016
None
0.99A 5y2tA-5xwyA:
undetectable
5y2tA-5xwyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
3 / 3 PHE A 680
ASP A 679
LYS A 683
None
None
U  B  43 ( 2.8A)
0.88A 6awtD-5xwyA:
undetectable
6awtD-5xwyA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 8 ASP A1078
ARG A 346
ASN A 369
TYR A 155
None
1.20A 6hisA-5xwyA:
undetectable
6hisB-5xwyA:
undetectable
6hisA-5xwyA:
5.02
6hisB-5xwyA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 8 ASP A1078
ARG A 346
ASN A 369
TYR A 155
None
1.20A 6hisB-5xwyA:
undetectable
6hisC-5xwyA:
undetectable
6hisB-5xwyA:
5.02
6hisC-5xwyA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 8 ASP A1078
ARG A 346
ASN A 369
TYR A 155
None
1.20A 6hisC-5xwyA:
undetectable
6hisD-5xwyA:
undetectable
6hisC-5xwyA:
5.02
6hisD-5xwyA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 8 ASP A1078
ARG A 346
ASN A 369
TYR A 155
None
1.20A 6hisD-5xwyA:
undetectable
6hisE-5xwyA:
undetectable
6hisD-5xwyA:
5.02
6hisE-5xwyA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 8 ASN A 369
TYR A 155
ASP A1078
ARG A 346
None
1.20A 6hisA-5xwyA:
undetectable
6hisE-5xwyA:
undetectable
6hisA-5xwyA:
5.02
6hisE-5xwyA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis)
4 / 5 LYS A 207
GLU A 211
GLU A 229
PHE A 226
None
1.28A 6hrjA-5xwyA:
undetectable
6hrjA-5xwyA:
11.80