SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xxs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		4 / 5 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.28A 1p6kB-5xxsA:
undetectable		 1p6kB-5xxsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		4 / 5 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.25A 1zzuA-5xxsA:
undetectable		 1zzuA-5xxsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		4 / 5 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.25A 1zzuB-5xxsA:
undetectable		 1zzuB-5xxsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		5 / 9 LEU A  29
LEU A  16
LEU A  17
LEU A  44
ALA A  56
 None
 1.13A 5dqfA-5xxsA:
undetectable		 5dqfA-5xxsA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		4 / 5 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.25A 5vunA-5xxsA:
undetectable		 5vunA-5xxsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		4 / 4 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.26A 5vuoA-5xxsA:
0.0		 5vuoA-5xxsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xxs PROTEIN RIBT
(Bacillus
subtilis) 		4 / 4 GLY A  83
GLN A  85
TRP A  47
VAL A  54
 COA  A 200 (-3.6A)
None
None
None
 1.25A 6auuB-5xxsA:
0.0		 6auuB-5xxsA:
undetectable