SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5xxu RIBOSOMAL PROTEIN
ES19
(Toxoplasma
gondii) 		3 / 3 ALA T  53
VAL T  50
TRP T  65
 None
A  21501 ( 4.5A)
None
 0.84A 1av2C-5xxuT:
undetectable
1av2D-5xxuT:
undetectable		 1av2C-5xxuT:
12.73
1av2D-5xxuT:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_B_BHSB2610_1
(NITRIC OXIDE
SYNTHASE)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		4 / 6 PHE F  49
GLU c  51
VAL c  12
ARG F  48
 None
None
None
C  21613 ( 4.4A)
 1.39A 1dmiA-5xxuF:
undetectable
1dmiB-5xxuF:
undetectable		 1dmiA-5xxuF:
19.13
1dmiB-5xxuF:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 6 THR B  46
LEU O  52
GLY O  54
TYR B  66
 None
None
U  2 915 ( 4.2A)
None
 1.10A 1gtiC-5xxuB:
undetectable		 1gtiC-5xxuB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 5xxu RIBOSOMAL PROTEIN
ES4
RIBOSOMAL PROTEIN
ES6
(Toxoplasma
gondii) 		4 / 5 TYR G 206
GLU G 202
TYR E 149
PRO E 150
 None
 1.23A 1i7zB-5xxuG:
undetectable		 1i7zB-5xxuG:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5xxu RIBOSOMAL PROTEIN
US12
(Toxoplasma
gondii) 		4 / 4 HIS X 110
ALA X 111
PHE X 105
GLY X 109
 U  21131 ( 4.3A)
U  21131 ( 4.7A)
None
None
 1.38A 1mj2B-5xxuX:
undetectable		 1mj2B-5xxuX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5xxu RIBOSOMAL PROTEIN
US12
(Toxoplasma
gondii) 		4 / 4 HIS X 110
ALA X 111
PHE X 105
GLY X 109
 U  21131 ( 4.3A)
U  21131 ( 4.7A)
None
None
 1.38A 1mjoB-5xxuX:
undetectable		 1mjoB-5xxuX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5xxu RIBOSOMAL PROTEIN
US12
(Toxoplasma
gondii) 		4 / 4 HIS X 110
ALA X 111
PHE X 105
GLY X 109
 U  21131 ( 4.3A)
U  21131 ( 4.7A)
None
None
 1.35A 1mjoA-5xxuX:
undetectable		 1mjoA-5xxuX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5xxu RIBOSOMAL PROTEIN
US12
(Toxoplasma
gondii) 		4 / 4 HIS X 110
ALA X 111
PHE X 105
GLY X 109
 U  21131 ( 4.3A)
U  21131 ( 4.7A)
None
None
 1.41A 1mjoD-5xxuX:
undetectable		 1mjoD-5xxuX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		5 / 12 LEU c  55
LEU c  57
ARG c  62
VAL F 127
ALA c  64
 None
 1.13A 1n5xA-5xxuc:
undetectable		 1n5xA-5xxuc:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		5 / 12 LEU c  55
LEU c  57
ARG c  62
VAL F 127
ALA c  64
 None
 1.13A 1n5xB-5xxuc:
undetectable		 1n5xB-5xxuc:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5xxu RIBOSOMAL PROTEIN
US5
RIBOSOMAL PROTEIN
US8
(Toxoplasma
gondii) 		5 / 12 SER C 167
LEU W  93
LEU W  94
PRO W  95
TYR W 128
 U  21092 ( 3.6A)
None
None
None
U  21094 ( 4.8A)
 1.36A 1p33C-5xxuC:
undetectable		 1p33C-5xxuC:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5xxu RIBOSOMAL PROTEIN
US7
RIBOSOMAL PROTEIN
US9
(Toxoplasma
gondii) 		4 / 6 TYR Q  84
GLU F  58
PRO F  55
VAL F  37
 None
 1.43A 1q13A-5xxuQ:
undetectable		 1q13A-5xxuQ:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		3 / 3 GLU C  67
TRP C  37
LYS C 127
 None
None
U  21285 ( 3.1A)
 1.41A 1qu2A-5xxuC:
undetectable		 1qu2A-5xxuC:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 ILE C 137
ASP C  87
GLY C 113
LEU C 144
LEU C  84
 None
 1.06A 1rjdA-5xxuC:
undetectable		 1rjdA-5xxuC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 ILE C 137
ASP C  87
GLY C 113
LEU C 144
LEU C  84
 None
 1.07A 1rjdB-5xxuC:
undetectable		 1rjdB-5xxuC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 ILE C 137
ASP C  87
GLY C 113
LEU C 144
LEU C  84
 None
 1.04A 1rjdC-5xxuC:
undetectable		 1rjdC-5xxuC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5xxu RIBOSOMAL PROTEIN
US17
(Toxoplasma
gondii) 		4 / 7 VAL L 109
VAL L  77
CYH L 116
ARG L  71
 C  2 305 ( 4.9A)
None
None
U  2 304 ( 3.2A)
 1.31A 1t46A-5xxuL:
undetectable		 1t46A-5xxuL:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5xxu RIBOSOMAL PROTEIN
ES19
(Toxoplasma
gondii) 		3 / 3 ALA T  53
VAL T  50
TRP T  65
 None
A  21501 ( 4.5A)
None
 0.81A 1w5uC-5xxuT:
undetectable
1w5uD-5xxuT:
undetectable		 1w5uC-5xxuT:
12.73
1w5uD-5xxuT:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5xxu RIBOSOMAL PROTEIN
US2
(Toxoplasma
gondii) 		3 / 3 HIS A  25
ASP A 150
ASN A  30
 None
 0.82A 1wg8B-5xxuA:
undetectable		 1wg8B-5xxuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		4 / 5 TRP C 251
PRO C 247
LEU C  43
GLY C  44
 None
 1.40A 1ya4C-5xxuC:
undetectable		 1ya4C-5xxuC:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
US14
(Toxoplasma
gondii;
Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 8 MET d  36
ARG D  78
TRP K  69
ARG d  20
 None
 1.44A 1zlqB-5xxud:
undetectable		 1zlqB-5xxud:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5xxu RIBOSOMAL PROTEIN
ES17
(Toxoplasma
gondii) 		4 / 4 VAL R  38
LEU R  71
ILE R  61
LEU R  57
 None
 1.01A 2byoA-5xxuR:
undetectable		 2byoA-5xxuR:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5xxu RIBOSOMAL PROTEIN
US13
(Toxoplasma
gondii) 		4 / 4 LEU S  18
ILE S  46
ILE S  72
ALA S  71
 None
 0.85A 2i30A-5xxuS:
undetectable		 2i30A-5xxuS:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5xxu RIBOSOMAL PROTEIN
ES19
(Toxoplasma
gondii) 		3 / 3 TRP T  65
ALA T  53
VAL T  50
 None
None
A  21501 ( 4.5A)
 0.82A 2izqA-5xxuT:
undetectable
2izqB-5xxuT:
undetectable		 2izqA-5xxuT:
12.73
2izqB-5xxuT:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES24
(Toxoplasma
gondii) 		4 / 6 PHE Y  50
ILE Y  46
VAL Y  27
ALA Y  76
 U  2 778 ( 4.2A)
None
None
None
 1.09A 2j5mA-5xxuY:
undetectable		 2j5mA-5xxuY:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 5xxu RIBOSOMAL PROTEIN
ES21
RIBOSOMAL PROTEIN
US8
(Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 6 ALA V  66
ASP V  65
GLU V  63
ARG W  22
 None
None
None
A  21036 ( 4.0A)
 1.16A 2ouzA-5xxuV:
undetectable		 2ouzA-5xxuV:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5xxu RIBOSOMAL PROTEIN
US2
(Toxoplasma
gondii) 		4 / 6 LEU A 179
TYR A 176
ILE A 162
ILE A 124
 None
 0.95A 2q8hA-5xxuA:
undetectable		 2q8hA-5xxuA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5xxu RIBOSOMAL PROTEIN
ES21
RIBOSOMAL PROTEIN
US2
(Toxoplasma
gondii) 		3 / 3 ARG V  61
GLY V  62
SER A 138
 U  21077 ( 3.7A)
None
None
 0.64A 2xctB-5xxuV:
undetectable		 2xctB-5xxuV:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5xxu RIBOSOMAL PROTEIN
US2
RIBOSOMAL PROTEIN
ES21
(Toxoplasma
gondii;
Toxoplasma
gondii) 		3 / 3 GLU V  63
ASP V  65
TYR A  38
 None
 0.86A 2yvlB-5xxuV:
undetectable		 2yvlB-5xxuV:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5xxu RIBOSOMAL PROTEIN
US4
(Toxoplasma
gondii) 		4 / 7 VAL J 172
GLY J 170
PRO J 163
ARG J 175
 A  2 510 ( 4.6A)
U  2 512 ( 3.4A)
U  2 512 ( 4.4A)
A  2 537 ( 3.8A)
 0.84A 3bjwC-5xxuJ:
undetectable		 3bjwC-5xxuJ:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5xxu RIBOSOMAL PROTEIN
US4
(Toxoplasma
gondii) 		4 / 8 VAL J 172
GLY J 170
PRO J 163
ARG J 175
 A  2 510 ( 4.6A)
U  2 512 ( 3.4A)
U  2 512 ( 4.4A)
A  2 537 ( 3.8A)
 0.85A 3bjwA-5xxuJ:
undetectable		 3bjwA-5xxuJ:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5xxu RIBOSOMAL PROTEIN
ES4
(Toxoplasma
gondii) 		3 / 3 ARG E 245
VAL E 225
THR E 220
 U  2 788 ( 4.2A)
None
G  2 750 ( 4.0A)
 0.39A 3cyxA-5xxuE:
undetectable		 3cyxA-5xxuE:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xxu RIBOSOMAL PROTEIN
US10
RIBOSOMAL PROTEIN
US14
RIBOSOMAL PROTEIN
US3
(Toxoplasma
gondii) 		5 / 12 ALA D  21
GLN D  20
ASN d  46
VAL d  29
ILE U 177
 None
None
None
G  21194 ( 4.4A)
None
 1.02A 3e00A-5xxuD:
undetectable		 3e00A-5xxuD:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 ALA C 199
GLY C 120
VAL C 112
GLY C 113
VAL C 147
 None
 1.07A 3f8wA-5xxuC:
undetectable		 3f8wA-5xxuC:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 ALA C 199
GLY C 120
VAL C 112
GLY C 113
VAL C 147
 None
 1.09A 3f8wC-5xxuC:
undetectable		 3f8wC-5xxuC:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES25
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		4 / 6 HIS Z 149
ARG F  79
PHE F   8
PRO F  38
 C  21528 ( 4.9A)
G  21527 ( 4.9A)
None
None
 1.32A 3gclA-5xxuZ:
undetectable		 3gclA-5xxuZ:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5xxu RIBOSOMAL PROTEIN
ES19
(Toxoplasma
gondii) 		3 / 3 ALA T  53
VAL T  50
TRP T  65
 None
A  21501 ( 4.5A)
None
 0.79A 3l8lA-5xxuT:
undetectable
3l8lB-5xxuT:
undetectable		 3l8lA-5xxuT:
12.73
3l8lB-5xxuT:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5xxu RIBOSOMAL PROTEIN
ES19
(Toxoplasma
gondii) 		3 / 3 ALA T  53
VAL T  50
TRP T  65
 None
A  21501 ( 4.5A)
None
 0.76A 3l8lC-5xxuT:
undetectable
3l8lD-5xxuT:
undetectable		 3l8lC-5xxuT:
12.73
3l8lD-5xxuT:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5xxu RIBOSOMAL PROTEIN
ES21
(Toxoplasma
gondii) 		5 / 10 VAL V  58
SER V  64
GLY V  56
VAL V  32
GLY V  30
 None
None
U  21077 ( 4.7A)
None
None
 1.29A 3ls4H-5xxuV:
undetectable		 3ls4H-5xxuV:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 5xxu RIBOSOMAL PROTEIN
US19
(Toxoplasma
gondii) 		3 / 3 PRO P  78
SER P  97
ASN P  71
 None
 0.94A 3lslG-5xxuP:
undetectable		 3lslG-5xxuP:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5xxu RIBOSOMAL PROTEIN
US2
(Toxoplasma
gondii) 		3 / 3 ILE A  66
VAL A 183
ARG A 187
 None
 0.73A 3p73A-5xxuA:
undetectable		 3p73A-5xxuA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5xxu RIBOSOMAL PROTEIN
ES25
(Toxoplasma
gondii) 		4 / 5 SER Z 127
ARG Z 130
PRO Z 115
TYR Z 153
 C  21531 ( 2.5A)
C  21531 ( 2.8A)
None
None
 1.37A 3sufC-5xxuZ:
undetectable		 3sufC-5xxuZ:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		3 / 3 LYS O 101
VAL O  35
HIS O  99
 None
 0.75A 3tj7A-5xxuO:
undetectable		 3tj7A-5xxuO:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 5xxu RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii) 		4 / 4 LYS a  66
PRO a  65
LEU a  64
ASN a  43
 None
 1.33A 3tpxC-5xxua:
undetectable		 3tpxC-5xxua:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5xxu RIBOSOMAL PROTEIN
US10
RIBOSOMAL PROTEIN
US9
(Toxoplasma
gondii) 		3 / 3 PHE Q 134
LYS U 181
SER U 182
 None
C  21416 ( 3.5A)
C  21275 ( 4.4A)
 1.34A 3tyeB-5xxuQ:
undetectable		 3tyeB-5xxuQ:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5xxu RIBOSOMAL PROTEIN
US4
(Toxoplasma
gondii) 		4 / 7 GLU J  33
THR J 100
VAL J 101
LEU J 105
 None
 0.86A 3uniA-5xxuJ:
undetectable		 3uniA-5xxuJ:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xxu RIBOSOMAL PROTEIN
US9
(Toxoplasma
gondii) 		3 / 3 SER Q  75
GLY Q  76
GLN Q  82
 A  21479 ( 4.8A)
A  21479 ( 3.8A)
C  21478 ( 3.4A)
 0.63A 3v4tH-5xxuQ:
undetectable		 3v4tH-5xxuQ:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5xxu RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
US3
(Toxoplasma
gondii) 		5 / 12 ARG D  67
GLU D  70
TYR K  74
VAL K  30
VAL D  74
 None
 1.46A 3w2tA-5xxuD:
undetectable		 3w2tA-5xxuD:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5xxu RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
US3
(Toxoplasma
gondii) 		5 / 12 ARG D  67
GLU D  70
TYR K  74
VAL K  30
VAL D  74
 None
 1.45A 3w2tB-5xxuD:
undetectable		 3w2tB-5xxuD:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5xxu RIBOSOMAL PROTEIN
US2
RIBOSOMAL PROTEIN
ES17
(Toxoplasma
gondii;
Toxoplasma
gondii) 		3 / 3 ARG A 181
ARG R  88
ASP A  14
 None
 0.90A 3wipG-5xxuA:
undetectable
3wipH-5xxuA:
undetectable		 3wipG-5xxuA:
22.19
3wipH-5xxuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
US14
(Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 5 PHE d  50
GLY d  33
ILE d  48
VAL D  18
 None
 0.81A 3wrkA-5xxud:
undetectable		 3wrkA-5xxud:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5xxu RIBOSOMAL PROTEIN
US5
RIBOSOMAL PROTEIN
ES21
(Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 7 PRO V  25
ILE V  24
GLY V  30
SER C  62
 None
 0.88A 4a3uB-5xxuV:
undetectable		 4a3uB-5xxuV:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5xxu RIBOSOMAL PROTEIN
US15
(Toxoplasma
gondii) 		3 / 3 ASP N 110
LYS N 109
ASP N 108
 G  2 874 ( 3.9A)
G  2 973 ( 3.4A)
G  2 875 ( 3.0A)
 0.66A 4a7tA-5xxuN:
undetectable		 4a7tA-5xxuN:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xxu RIBOSOMAL PROTEIN
US2
(Toxoplasma
gondii) 		4 / 6 ILE A 124
VAL A 158
ILE A 160
CYH A 161
 None
 0.90A 4asdA-5xxuA:
undetectable		 4asdA-5xxuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		4 / 6 PHE F  49
GLU c  51
VAL c  12
ARG F  48
 None
None
None
C  21613 ( 4.4A)
 1.44A 4d35A-5xxuF:
undetectable
4d35B-5xxuF:
undetectable		 4d35A-5xxuF:
19.18
4d35B-5xxuF:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 9 ALA C 108
ALA C 140
ILE C 138
GLY C 135
ILE C 137
 None
 0.98A 4eatB-5xxuC:
undetectable		 4eatB-5xxuC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xxu RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		5 / 12 GLY F 107
GLY F 108
ILE F 178
VAL F  99
ILE F 142
 None
 1.27A 4fglA-5xxuF:
undetectable
4fglB-5xxuF:
undetectable		 4fglA-5xxuF:
24.07
4fglB-5xxuF:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5xxu RIBOSOMAL PROTEIN
ES4
(Toxoplasma
gondii) 		4 / 5 GLY E 132
VAL E 130
PRO E 137
TYR E 149
 U  2 252 ( 4.5A)
A  2 251 ( 4.8A)
None
None
 0.70A 4grkA-5xxuE:
undetectable		 4grkA-5xxuE:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5xxu RIBOSOMAL PROTEIN
ES27
RIBOSOMAL PROTEIN
US8
(Toxoplasma
gondii) 		4 / 7 HIS b   7
PRO b   8
VAL W  62
GLU W  51
 None
 1.11A 4hvrA-5xxub:
undetectable		 4hvrA-5xxub:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 5xxu RIBOSOMAL PROTEIN
US3
(Toxoplasma
gondii) 		5 / 12 VAL D 140
LEU D 144
LEU D 184
VAL D 186
LEU D 111
 None
 0.99A 4k13A-5xxuD:
undetectable		 4k13A-5xxuD:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5xxu RIBOSOMAL PROTEIN
ES4
(Toxoplasma
gondii) 		4 / 6 ASP E  88
ASP E  73
ASN E  74
ASP E 143
 None
 0.93A 4mdaA-5xxuE:
undetectable		 4mdaA-5xxuE:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5xxu RIBOSOMAL PROTEIN
ES4
(Toxoplasma
gondii) 		4 / 6 ASP E  88
ASP E  73
ASN E  74
ASP E 143
 None
 1.20A 4mdbA-5xxuE:
undetectable		 4mdbA-5xxuE:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xxu RIBOSOMAL PROTEIN
US15
(Toxoplasma
gondii) 		4 / 6 TYR N 141
LEU N 135
ASP N  87
ALA N  81
 None
None
G  2 864 ( 4.4A)
None
 1.11A 4nkvC-5xxuN:
undetectable		 4nkvC-5xxuN:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xxu RIBOSOMAL PROTEIN
ES6
(Toxoplasma
gondii) 		4 / 5 GLY G  47
ASP G  39
GLU G  44
VAL G  18
 None
 1.10A 4nkvD-5xxuG:
undetectable		 4nkvD-5xxuG:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5xxu RIBOSOMAL PROTEIN
ES8
(Toxoplasma
gondii) 		3 / 3 LYS I 203
ASN I  88
ASP I 200
 None
 0.80A 4o1eA-5xxuI:
undetectable		 4o1eA-5xxuI:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5xxu RIBOSOMAL PROTEIN
ES6
(Toxoplasma
gondii) 		3 / 3 ILE G 173
ASP G 152
ARG G 159
 A  2  77 ( 4.5A)
None
U  2  76 ( 3.4A)
 0.82A 4pstA-5xxuG:
undetectable		 4pstA-5xxuG:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
ES10
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 12 PHE K  75
GLU D  70
ARG D  67
GLU D  33
GLY D  35
 None
 1.14A 4q15B-5xxuK:
undetectable		 4q15B-5xxuK:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		4 / 7 PHE C 218
LEU C 222
ALA C 111
MET C  89
 None
 0.98A 4rjdB-5xxuC:
undetectable		 4rjdB-5xxuC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		4 / 6 PHE F  49
GLU c  51
VAL c  12
ARG F  48
 None
None
None
C  21613 ( 4.4A)
 1.47A 4uh9A-5xxuF:
undetectable
4uh9B-5xxuF:
undetectable		 4uh9A-5xxuF:
19.18
4uh9B-5xxuF:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xxu RIBOSOMAL PROTEIN
US11
RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 11 ASN a  43
LEU a  64
LEU a  53
ALA O 117
LEU O 121
 None
 1.06A 4wg0F-5xxua:
undetectable
4wg0G-5xxua:
undetectable
4wg0H-5xxua:
undetectable		 4wg0F-5xxua:
11.76
4wg0G-5xxua:
11.76
4wg0H-5xxua:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xxu RIBOSOMAL PROTEIN
US11
RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 11 ASN a  43
LEU a  64
LEU a  53
ALA O 117
LEU O 121
 None
 1.12A 4wg0H-5xxua:
undetectable
4wg0I-5xxua:
undetectable
4wg0J-5xxua:
undetectable		 4wg0H-5xxua:
11.76
4wg0I-5xxua:
11.76
4wg0J-5xxua:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xxu RIBOSOMAL PROTEIN
US11
RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 11 ASN a  43
LEU a  64
LEU a  53
ALA O 117
LEU O 121
 None
 1.09A 4wg0J-5xxua:
undetectable
4wg0K-5xxua:
undetectable
4wg0L-5xxua:
undetectable		 4wg0J-5xxua:
11.76
4wg0K-5xxua:
11.76
4wg0L-5xxua:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xxu RIBOSOMAL PROTEIN
US11
RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 11 ALA O 117
LEU O 121
LEU a  53
ASN a  43
LEU a  64
 None
 1.12A 4wg0I-5xxuO:
undetectable
4wg0J-5xxuO:
undetectable
4wg0K-5xxuO:
undetectable		 4wg0I-5xxuO:
6.00
4wg0J-5xxuO:
6.00
4wg0K-5xxuO:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xxu RIBOSOMAL PROTEIN
US11
RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 11 ALA O 117
LEU O 121
LEU a  53
ASN a  43
LEU a  64
 None
 1.11A 4wg0K-5xxuO:
undetectable
4wg0L-5xxuO:
undetectable
4wg0M-5xxuO:
undetectable		 4wg0K-5xxuO:
6.00
4wg0L-5xxuO:
6.00
4wg0M-5xxuO:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
ES10
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 12 PHE K  75
GLU D  70
ARG D  67
GLU D  33
GLY D  35
 None
 1.22A 4ydqA-5xxuK:
undetectable		 4ydqA-5xxuK:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5xxu RIBOSOMAL PROTEIN
US12
RIBOSOMAL PROTEIN
ES30
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 12 TYR X  93
SER X  90
SER e   7
ALA X  65
ASP X  88
 None
None
None
A  2 566 ( 3.1A)
A  2 566 ( 3.0A)
 1.22A 4ymgB-5xxuX:
undetectable		 4ymgB-5xxuX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5xxu RIBOSOMAL PROTEIN
ES24
(Toxoplasma
gondii) 		3 / 3 TYR Y 111
LYS Y 115
LYS Y 112
 G  2 457 ( 4.4A)
G  2  57 ( 2.7A)
G  2 458 ( 2.6A)
 1.33A 5dbyA-5xxuY:
undetectable		 5dbyA-5xxuY:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		5 / 10 LEU c   6
ALA c   7
LEU c  55
ARG F 134
GLY c  52
 None
 1.35A 5dx3A-5xxuc:
undetectable		 5dx3A-5xxuc:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 11 ALA O  84
ALA O  82
VAL O  61
LEU O 129
VAL O  59
 None
 1.32A 5eb5A-5xxuO:
undetectable		 5eb5A-5xxuO:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 10 ALA O  84
ALA O  82
VAL O  61
LEU O 129
VAL O  59
 None
 1.33A 5eb5B-5xxuO:
undetectable		 5eb5B-5xxuO:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5xxu RIBOSOMAL PROTEIN
US10
RIBOSOMAL PROTEIN
US14
(Toxoplasma
gondii) 		5 / 12 VAL d  21
THR U 179
PHE U 194
GLN d  47
PHE d  41
 None
G  21194 ( 4.2A)
None
None
None
 1.37A 5hgcA-5xxud:
undetectable		 5hgcA-5xxud:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5xxu RIBOSOMAL PROTEIN
ES7
(Toxoplasma
gondii) 		5 / 12 ILE H 133
THR H 174
PHE H 191
LEU H 130
VAL H 156
 None
 1.23A 5hw4A-5xxuH:
undetectable		 5hw4A-5xxuH:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5xxu RIBOSOMAL PROTEIN
ES27
(Toxoplasma
gondii) 		3 / 3 VAL b  44
GLN b  63
CYH b  69
 None
 0.87A 5icxC-5xxub:
undetectable
5icxF-5xxub:
undetectable		 5icxC-5xxub:
17.44
5icxF-5xxub:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5xxu RIBOSOMAL PROTEIN
US15
(Toxoplasma
gondii) 		5 / 12 PRO N  30
VAL N  33
ILE N  37
ALA N  38
VAL N  63
 None
 0.58A 5j2tC-5xxuN:
undetectable		 5j2tC-5xxuN:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		3 / 3 VAL O 137
HIS O  99
VAL O  35
 None
 0.65A 5jmnC-5xxuO:
undetectable		 5jmnC-5xxuO:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5xxu RIBOSOMAL PROTEIN
US17
(Toxoplasma
gondii) 		3 / 3 VAL L  77
HIS L 112
VAL L 142
 None
 0.65A 5jmnC-5xxuL:
undetectable		 5jmnC-5xxuL:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		3 / 3 LYS O 101
ASP O 136
ILE O  47
 None
 0.89A 5kc4E-5xxuO:
undetectable		 5kc4E-5xxuO:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 9 GLU B  67
VAL B  68
GLY O  54
SER O  53
THR O  50
 None
None
U  2 915 ( 4.2A)
None
U  2 915 ( 4.0A)
 1.36A 5ksgB-5xxuB:
undetectable		 5ksgB-5xxuB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 9 GLU B  67
VAL B  68
GLY O  54
SER O  53
THR O  50
 None
None
U  2 915 ( 4.2A)
None
U  2 915 ( 4.0A)
 1.33A 5ksnA-5xxuB:
undetectable		 5ksnA-5xxuB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 9 GLU B  67
VAL B  68
GLY O  54
SER O  53
THR O  50
 None
None
U  2 915 ( 4.2A)
None
U  2 915 ( 4.0A)
 1.35A 5ksnB-5xxuB:
undetectable		 5ksnB-5xxuB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 9 GLU B  67
VAL B  68
GLY O  54
SER O  53
THR O  50
 None
None
U  2 915 ( 4.2A)
None
U  2 915 ( 4.0A)
 1.34A 5kt8B-5xxuB:
undetectable		 5kt8B-5xxuB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 10 ALA O 123
ALA O 117
GLY O 116
ALA O  79
THR O  45
 None
 1.02A 5lf3H-5xxuO:
undetectable
5lf3I-5xxuO:
undetectable		 5lf3H-5xxuO:
22.98
5lf3I-5xxuO:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 10 ALA O 123
ALA O 117
GLY O 116
ALA O  79
THR O  45
 None
 1.02A 5lf3V-5xxuO:
undetectable
5lf3W-5xxuO:
undetectable		 5lf3V-5xxuO:
22.98
5lf3W-5xxuO:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 11 ALA O 123
ALA O 117
GLY O 116
ALA O  79
THR O  45
 None
 1.01A 5lf7H-5xxuO:
undetectable
5lf7I-5xxuO:
undetectable		 5lf7H-5xxuO:
22.98
5lf7I-5xxuO:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5xxu RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 11 ALA O 123
ALA O 117
GLY O 116
ALA O  79
THR O  45
 None
 1.00A 5lf7V-5xxuO:
undetectable
5lf7W-5xxuO:
undetectable		 5lf7V-5xxuO:
22.98
5lf7W-5xxuO:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 9 GLU B  67
VAL B  68
GLY O  54
SER O  53
THR O  50
 None
None
U  2 915 ( 4.2A)
None
U  2 915 ( 4.0A)
 1.35A 5sxsB-5xxuB:
undetectable		 5sxsB-5xxuB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5xxu RIBOSOMAL PROTEIN
US2
RIBOSOMAL PROTEIN
ES21
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 12 PRO A 120
ILE A 146
LEU A  76
VAL A 143
LEU V  68
 None
 1.15A 5tiwA-5xxuA:
undetectable		 5tiwA-5xxuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 10 ALA C 225
LEU C 177
VAL C 166
LEU C 196
VAL C 147
 None
 1.10A 5v02B-5xxuC:
undetectable
5v02R-5xxuC:
undetectable		 5v02B-5xxuC:
16.36
5v02R-5xxuC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		4 / 6 ARG C 176
PHE C 218
ILE C 195
THR C 191
 U  21093 ( 3.3A)
None
None
U  2   5 ( 4.8A)
 1.14A 5vceA-5xxuC:
undetectable		 5vceA-5xxuC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7
(Toxoplasma
gondii) 		4 / 7 PHE F  49
GLU c  51
VAL c  12
ARG F  48
 None
None
None
C  21613 ( 4.4A)
 1.46A 5vvdA-5xxuF:
undetectable
5vvdB-5xxuF:
undetectable		 5vvdA-5xxuF:
18.58
5vvdB-5xxuF:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xxu RIBOSOMAL PROTEIN
US4
RIBOSOMAL PROTEIN
ES30
(Toxoplasma
gondii;
Toxoplasma
gondii) 		3 / 3 ARG J 126
PHE e  40
LEU J  36
 A  2 475 ( 3.6A)
None
None
 0.93A 5x1bC-5xxuJ:
undetectable		 5x1bC-5xxuJ:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5xxu RIBOSOMAL PROTEIN
US13
(Toxoplasma
gondii) 		5 / 11 VAL S 101
GLY S  37
SER S  43
ALA S  73
LEU S  18
 None
U  21565 ( 3.3A)
None
None
None
 1.17A 5x6yA-5xxuS:
undetectable		 5x6yA-5xxuS:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5xxu RIBOSOMAL PROTEIN
US13
(Toxoplasma
gondii) 		5 / 11 VAL S 101
GLY S  37
SER S  43
ALA S  73
LEU S  18
 None
U  21565 ( 3.3A)
None
None
None
 1.21A 5x6yC-5xxuS:
undetectable		 5x6yC-5xxuS:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		4 / 7 ASN B  95
ASP O  28
GLY O  29
ASN B  42
 None
 0.92A 5x7pA-5xxuB:
undetectable		 5x7pA-5xxuB:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xxu RIBOSOMAL PROTEIN
US3
RIBOSOMAL PROTEIN
ES10
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 12 PHE K  75
GLU D  70
ARG D  67
GLU D  33
GLY D  35
 None
 1.15A 5xiqD-5xxuK:
undetectable		 5xiqD-5xxuK:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5xxu RIBOSOMAL PROTEIN
US19
RIBOSOMAL PROTEIN
US13
(Toxoplasma
gondii;
Toxoplasma
gondii) 		5 / 9 GLY P  24
VAL P  25
GLU P  26
ASP S  94
GLY S  95
 None
 1.39A 5zniA-5xxuP:
undetectable		 5zniA-5xxuP:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5xxu RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
US3
(Toxoplasma
gondii) 		5 / 12 ARG D  67
GLU D  70
TYR K  74
VAL K  30
VAL D  74
 None
 1.47A 6b1eB-5xxuD:
undetectable		 6b1eB-5xxuD:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 5xxu RIBOSOMAL PROTEIN
US2
(Toxoplasma
gondii) 		5 / 9 ALA A 101
SER A  85
GLY A  84
ALA A  99
SER A  92
 None
 1.21A 6bklE-5xxuA:
undetectable
6bklF-5xxuA:
undetectable
6bklG-5xxuA:
undetectable
6bklH-5xxuA:
undetectable		 6bklE-5xxuA:
8.22
6bklF-5xxuA:
8.22
6bklG-5xxuA:
8.22
6bklH-5xxuA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 LEU C 196
GLY C 197
SER C 143
VAL C 112
ASP C  87
 None
 1.24A 6bxlA-5xxuC:
undetectable		 6bxlA-5xxuC:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		5 / 12 LEU C 196
GLY C 197
SER C 143
VAL C 112
ASP C  87
 None
 1.36A 6bxlB-5xxuC:
undetectable		 6bxlB-5xxuC:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5xxu RIBOSOMAL PROTEIN
ES4
(Toxoplasma
gondii) 		5 / 9 VAL E 227
GLY E 229
ILE E 169
LEU E 162
ARG E 125
 None
 1.50A 6c2mC-5xxuE:
undetectable		 6c2mC-5xxuE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11
(Toxoplasma
gondii) 		5 / 9 GLU B  67
VAL B  68
GLY O  54
SER O  53
THR O  50
 None
None
U  2 915 ( 4.2A)
None
U  2 915 ( 4.0A)
 1.34A 6cfqB-5xxuB:
undetectable		 6cfqB-5xxuB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5xxu RIBOSOMAL PROTEIN
US11
RIBOSOMAL PROTEIN
ES26
(Toxoplasma
gondii;
Toxoplasma
gondii) 		4 / 6 GLY O 153
SER a  29
ARG a  28
ARG a  22
 None
G  21779 ( 4.6A)
U  21761 ( 3.5A)
None
 1.14A 6dwdA-5xxuO:
undetectable
6dwdC-5xxuO:
undetectable		 6dwdA-5xxuO:
13.60
6dwdC-5xxuO:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5xxu RIBOSOMAL PROTEIN
US17
(Toxoplasma
gondii) 		4 / 5 SER L  67
VAL L  66
ASN L 141
PRO L 133
 A  2 113 ( 2.6A)
None
None
U  2 335 ( 3.5A)
 1.17A 6fi4A-5xxuL:
undetectable
6fi4B-5xxuL:
undetectable		 6fi4A-5xxuL:
19.51
6fi4B-5xxuL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5xxu RIBOSOMAL PROTEIN
US15
(Toxoplasma
gondii) 		5 / 12 VAL N  63
ILE N  71
SER N  57
VAL N  52
ILE N  50
 None
U  2 958 ( 4.3A)
None
U  2 957 ( 4.5A)
None
 1.29A 6gsdA-5xxuN:
undetectable		 6gsdA-5xxuN:
24.24