SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xya -
(-) 		4 / 8 THR A 407
GLY A 352
GLY A 380
GLY A 348
 None
 0.69A 1d0vA-5xyaA:
2.9		 1d0vA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5xya -
(-) 		5 / 12 HIS A1566
ASN A1563
SER A 356
GLY A 930
GLN A 929
 None
 1.16A 1ffyA-5xyaA:
undetectable		 1ffyA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5xya -
(-) 		5 / 12 GLN A1156
TYR A1267
TYR A1210
GLY A1204
GLY A1160
 None
 1.26A 1httB-5xyaA:
3.2		 1httB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5xya -
(-) 		5 / 12 GLN A1156
TYR A1267
TYR A1210
GLY A1204
GLY A1160
 None
 1.23A 1httC-5xyaA:
3.2		 1httC-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5xya -
(-) 		5 / 12 GLN A1156
TYR A1267
TYR A1210
GLY A1204
GLY A1160
 None
 1.20A 1httD-5xyaA:
3.2		 1httD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5xya -
(-) 		4 / 5 TYR A1106
LEU A1101
THR A1027
ARG A1034
 None
 1.16A 1i2wA-5xyaA:
undetectable		 1i2wA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5xya -
(-) 		5 / 11 ILE A 126
GLY A 303
HIS A 127
LEU A 680
GLY A 625
 None
 1.43A 1i7qA-5xyaA:
undetectable		 1i7qA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5xya -
(-) 		4 / 7 THR A 407
SER A 406
TYR A1526
LEU A1525
 None
 0.99A 1ibgL-5xyaA:
2.9		 1ibgL-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xya -
(-) 		4 / 8 THR A 407
GLY A 352
GLY A 380
GLY A 348
 None
 0.65A 1jhaA-5xyaA:
undetectable		 1jhaA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xya -
(-) 		5 / 11 LEU A 905
SER A 835
TYR A 831
LEU A 883
HIS A 881
 None
 1.43A 2idkA-5xyaA:
undetectable
2idkB-5xyaA:
2.6
2idkC-5xyaA:
1.5
2idkD-5xyaA:
1.7		 2idkA-5xyaA:
undetectable
2idkB-5xyaA:
undetectable
2idkC-5xyaA:
undetectable
2idkD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5xya -
(-) 		5 / 12 ALA A1026
LEU A1120
LEU A1094
PHE A1092
THR A1027
 None
 1.25A 2oipB-5xyaA:
undetectable		 2oipB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5xya -
(-) 		4 / 6 THR A1181
ASP A1198
ASN A1192
ASP A1285
 None
CA  A1705 (-3.5A)
CA  A1705 (-1.9A)
None
 1.13A 2okcA-5xyaA:
undetectable		 2okcA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5xya -
(-) 		5 / 10 PHE A 924
SER A1493
LEU A 973
THR A 975
GLY A 956
 None
 1.38A 2v0mA-5xyaA:
undetectable		 2v0mA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 5xya -
(-) 		4 / 6 TYR A 385
LEU A 401
ASN A 351
ASP A 587
 None
 1.43A 2w98A-5xyaA:
undetectable
2w98B-5xyaA:
undetectable		 2w98A-5xyaA:
undetectable
2w98B-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5xya -
(-) 		4 / 5 VAL A1527
TYR A1526
VAL A1002
ASP A 587
 None
 1.28A 2x45C-5xyaA:
undetectable		 2x45C-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5xya -
(-) 		5 / 12 SER A 617
ALA A 378
GLY A 403
GLY A 348
ASN A 581
 AES  A1701 (-1.4A)
None
None
None
None
 0.89A 3f8wA-5xyaA:
undetectable		 3f8wA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5xya -
(-) 		5 / 12 SER A 617
ALA A 378
GLY A 403
GLY A 348
ASN A 581
 AES  A1701 (-1.4A)
None
None
None
None
 0.90A 3f8wC-5xyaA:
undetectable		 3f8wC-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5xya -
(-) 		5 / 12 LEU A 833
GLY A 837
ILE A 830
PHE A 843
ASP A 850
 None
 1.00A 3gwwA-5xyaA:
undetectable		 3gwwA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5xya -
(-) 		5 / 12 LEU A 833
GLY A 837
ILE A 830
PHE A 843
ASP A 851
 None
 1.06A 3gwwA-5xyaA:
undetectable		 3gwwA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5xya -
(-) 		5 / 12 LEU A1518
LEU A1521
ARG A1508
GLY A1532
THR A1496
 None
None
None
None
SO4  A1704 (-2.6A)
 1.33A 3okxA-5xyaA:
undetectable		 3okxA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5xya -
(-) 		4 / 7 LEU A1056
ASP A1103
ALA A1099
TYR A1055
 None
 1.12A 3rodD-5xyaA:
undetectable		 3rodD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5xya -
(-) 		3 / 3 ASN A1347
ALA A1326
LYS A1332
 None
 0.83A 3runA-5xyaA:
1.1		 3runA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5xya -
(-) 		5 / 9 PHE A 843
VAL A 923
ILE A 830
GLY A 860
THR A 882
 None
 1.30A 3t3rB-5xyaA:
undetectable		 3t3rB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5xya -
(-) 		5 / 9 PHE A 843
VAL A 923
ILE A 830
GLY A 860
THR A 882
 None
 1.31A 3t3rC-5xyaA:
undetectable		 3t3rC-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5xya -
(-) 		5 / 10 PHE A 843
VAL A 923
ILE A 830
GLY A 860
THR A 882
 None
 1.27A 3t3rD-5xyaA:
undetectable		 3t3rD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5xya -
(-) 		4 / 6 LEU A 972
PHE A 924
ALA A 826
THR A 859
 None
 0.90A 3t3zA-5xyaA:
undetectable		 3t3zA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5xya -
(-) 		4 / 6 LEU A 972
PHE A 924
ALA A 826
THR A 859
 None
 0.96A 3t3zB-5xyaA:
undetectable		 3t3zB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5xya -
(-) 		4 / 6 LEU A 972
PHE A 924
ALA A 826
THR A 859
 None
 0.95A 3t3zD-5xyaA:
undetectable		 3t3zD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5xya -
(-) 		5 / 11 ALA A1026
GLU A1038
GLY A1121
HIS A1123
LEU A1120
 None
 1.23A 3uudA-5xyaA:
undetectable		 3uudA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xya -
(-) 		3 / 3 LYS A1348
ARG A1319
LEU A1375
 None
 1.30A 3v4tE-5xyaA:
undetectable		 3v4tE-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xya -
(-) 		4 / 6 TYR A 610
HIS A 609
VAL A 565
PHE A 301
 None
 1.17A 4a97E-5xyaA:
undetectable		 4a97E-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5xya -
(-) 		5 / 12 PRO A 597
VAL A 283
ILE A 286
GLN A 622
ILE A 623
 None
 0.85A 4a99A-5xyaA:
undetectable
4a99C-5xyaA:
undetectable		 4a99A-5xyaA:
undetectable
4a99C-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xya -
(-) 		4 / 7 LEU A 634
TYR A 691
LEU A 719
TYR A 633
 None
 1.10A 4b3qA-5xyaA:
1.5		 4b3qA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5xya -
(-) 		5 / 12 GLN A 622
LEU A 628
GLY A 285
GLY A 303
PRO A 621
 None
 0.92A 4gc9A-5xyaA:
undetectable		 4gc9A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5xya -
(-) 		4 / 6 ASP A 398
VAL A 384
SER A 671
PHE A 820
 None
 1.07A 4nedA-5xyaA:
undetectable		 4nedA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xya -
(-) 		4 / 5 VAL A1535
ILE A 150
PRO A 360
THR A1456
 None
 1.27A 4ze1A-5xyaA:
undetectable		 4ze1A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5xya -
(-) 		5 / 11 ALA A1026
GLU A1038
GLY A1121
HIS A1123
LEU A1120
 None
 1.21A 5dxgB-5xyaA:
undetectable		 5dxgB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5xya -
(-) 		5 / 12 GLN A1156
TYR A1267
TYR A1210
GLY A1204
GLY A1160
 None
 1.21A 5e3iA-5xyaA:
2.6		 5e3iA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5xya -
(-) 		5 / 11 GLN A1156
TYR A1267
TYR A1210
GLY A1204
GLY A1160
 None
 1.21A 5e3iB-5xyaA:
2.8		 5e3iB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5xya -
(-) 		3 / 3 MET A 281
HIS A 158
GLY A 611
 None
 0.79A 5gwzB-5xyaA:
undetectable		 5gwzB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5xya -
(-) 		4 / 5 ASP A 341
VAL A 171
GLY A 144
ALA A 169
 None
 0.99A 5hwaA-5xyaA:
undetectable		 5hwaA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5xya -
(-) 		4 / 6 ASP A1194
ASP A1186
ASN A1196
GLN A1165
 CA  A1705 (-2.2A)
None
None
None
 1.23A 5l6eA-5xyaA:
undetectable		 5l6eA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.54A 5qgjA-5xyaA:
undetectable		 5qgjA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.54A 5qgmA-5xyaA:
undetectable		 5qgmA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.58A 5qgnA-5xyaA:
undetectable		 5qgnA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.66A 5qgyA-5xyaA:
undetectable		 5qgyA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.65A 5qgzA-5xyaA:
undetectable		 5qgzA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.65A 5qh0A-5xyaA:
undetectable		 5qh0A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.66A 5qh2A-5xyaA:
undetectable		 5qh2A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.64A 5qh3A-5xyaA:
undetectable		 5qh3A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.61A 5qh5A-5xyaA:
undetectable		 5qh5A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.60A 5qh6A-5xyaA:
undetectable		 5qh6A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.62A 5qh7A-5xyaA:
undetectable		 5qh7A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.65A 5qhaA-5xyaA:
undetectable		 5qhaA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5xya -
(-) 		3 / 3 VAL A1422
VAL A1452
GLN A1481
 None
 0.62A 5qhhA-5xyaA:
undetectable		 5qhhA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5xya -
(-) 		4 / 5 TYR A 399
TYR A 385
GLY A 400
GLY A 583
 None
 1.17A 5x7pA-5xyaA:
undetectable		 5x7pA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5xya -
(-) 		4 / 6 TYR A 188
LEU A 327
GLU A1453
LEU A1455
 None
 1.19A 5xooA-5xyaA:
undetectable		 5xooA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5xya -
(-) 		5 / 11 GLY A 625
ALA A 626
ALA A 305
PRO A 306
VAL A 147
 None
 1.06A 5yk2A-5xyaA:
undetectable		 5yk2A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5xya -
(-) 		5 / 12 GLY A1313
SER A1384
VAL A1376
ARG A1379
ILE A1317
 None
 1.24A 6bxmA-5xyaA:
1.5		 6bxmA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5xya -
(-) 		4 / 6 GLY A1195
ASN A1196
ASP A1194
SER A1190
 None
None
CA  A1705 (-2.2A)
CA  A1705 (-2.4A)
 1.19A 6dwdA-5xyaA:
undetectable
6dwdC-5xyaA:
undetectable		 6dwdA-5xyaA:
undetectable
6dwdC-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xya -
(-) 		5 / 12 GLY A 352
PHE A 795
GLY A 678
THR A 595
THR A 407
 None
 1.02A 6e8qA-5xyaA:
undetectable		 6e8qA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5xya -
(-) 		5 / 10 ALA A 340
VAL A 373
ILE A 365
ALA A 364
ALA A 331
 None
 1.13A 6h1lA-5xyaA:
undetectable		 6h1lA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5xya -
(-) 		5 / 11 ALA A 340
VAL A 373
ILE A 365
ALA A 364
ALA A 331
 None
 1.16A 6h1lB-5xyaA:
undetectable		 6h1lB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5xya -
(-) 		5 / 12 VAL A 769
ILE A 660
VAL A 692
PHE A 712
PHE A 813
 None
 1.33A 6j21A-5xyaA:
0.8		 6j21A-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xya -
(-) 		4 / 5 GLY A 615
THR A 616
HIS A 279
SER A 346
 AES  A1701 (-3.5A)
AES  A1701 ( 4.7A)
AES  A1701 (-3.4A)
AES  A1701 ( 4.7A)
 0.94A 6jmjA-5xyaA:
undetectable		 6jmjA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xya -
(-) 		4 / 7 GLY A 615
THR A 616
HIS A 279
SER A 346
 AES  A1701 (-3.5A)
AES  A1701 ( 4.7A)
AES  A1701 (-3.4A)
AES  A1701 ( 4.7A)
 0.96A 6jnhA-5xyaA:
undetectable		 6jnhA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xya -
(-) 		4 / 6 GLY A 615
THR A 616
HIS A 279
SER A 346
 AES  A1701 (-3.5A)
AES  A1701 ( 4.7A)
AES  A1701 (-3.4A)
AES  A1701 ( 4.7A)
 0.96A 6jogA-5xyaA:
undetectable		 6jogA-5xyaA:
undetectable