SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5xyb -
(-) 		3 / 3 ASP A 328
THR A 164
GLU A 132
 None
 0.86A 1pj7A-5xybA:
undetectable		 1pj7A-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5xyb -
(-) 		3 / 3 GLU A 247
ASN A 245
TRP A 281
 None
 1.08A 1r15C-5xybA:
undetectable		 1r15C-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5xyb -
(-) 		3 / 3 GLU A 247
ASN A 245
TRP A 281
 None
 1.09A 1r15D-5xybA:
undetectable		 1r15D-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5xyb -
(-) 		3 / 3 GLU A 247
ASN A 245
TRP A 281
 None
 1.09A 1r15E-5xybA:
undetectable		 1r15E-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5xyb -
(-) 		3 / 3 GLU A 247
ASN A 245
TRP A 281
 None
 1.07A 1r15F-5xybA:
undetectable		 1r15F-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5xyb -
(-) 		4 / 7 PHE A 253
LEU A 242
VAL A 198
SER A 201
 None
 1.11A 1wrlA-5xybA:
undetectable
1wrlB-5xybA:
undetectable		 1wrlA-5xybA:
undetectable
1wrlB-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5xyb -
(-) 		3 / 3 ASN A 279
ASN A 307
ARG A 340
 None
 0.70A 2rlcA-5xybA:
undetectable		 2rlcA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5xyb -
(-) 		4 / 8 TYR A 159
ALA A 220
SER A 217
SER A 201
 None
 1.11A 3rodA-5xybA:
undetectable		 3rodA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_A_CLMA221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 9 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.35A 3u9fA-5xybA:
undetectable		 3u9fA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 12 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.36A 3u9fB-5xybA:
undetectable
3u9fC-5xybA:
undetectable		 3u9fB-5xybA:
undetectable
3u9fC-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 10 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.27A 3u9fE-5xybA:
undetectable		 3u9fE-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 12 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.32A 3u9fH-5xybA:
undetectable
3u9fI-5xybA:
undetectable		 3u9fH-5xybA:
undetectable
3u9fI-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 12 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.35A 3u9fJ-5xybA:
undetectable
3u9fK-5xybA:
undetectable		 3u9fJ-5xybA:
undetectable
3u9fK-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 10 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.43A 3u9fK-5xybA:
undetectable		 3u9fK-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 12 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.39A 3u9fJ-5xybA:
undetectable
3u9fL-5xybA:
undetectable		 3u9fJ-5xybA:
undetectable
3u9fL-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xyb -
(-) 		5 / 10 SER A 358
PHE A 167
SER A 351
LEU A 366
PHE A 276
 None
 1.32A 3u9fR-5xybA:
undetectable		 3u9fR-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5xyb -
(-) 		4 / 5 ASN A 245
LEU A 241
LEU A 210
ASN A 208
 None
 1.27A 4n09C-5xybA:
undetectable		 4n09C-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5xyb -
(-) 		3 / 3 LEU A 274
MET A 268
TYR A 234
 None
 0.92A 4p6xG-5xybA:
undetectable		 4p6xG-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5xyb -
(-) 		3 / 3 ARG A 138
LYS A 120
GLU A 124
 None
 0.80A 5d0yA-5xybA:
undetectable		 5d0yA-5xybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5xyb -
(-) 		4 / 8 ILE A 177
THR A 146
GLU A 184
SER A 183
 None
 1.11A 6fbvC-5xybA:
undetectable		 6fbvC-5xybA:
undetectable