SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1375_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	3 / 3	LEU A 155 TYR A 154 GLN A 157	None	0.64A	2wekA-5xyfA: undetectable	2wekA-5xyfA: 13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	5 / 12	LEU A 41 PHE A 14 GLY A 8 ASP A 172 VAL A 173	None	1.28A	2zznA-5xyfA: undetectable	2zznA-5xyfA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA602_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	4 / 7	SER A 186 ALA A 18 ALA A 17 ALA A 188	None	0.78A	3a2qA-5xyfA: undetectable	3a2qA-5xyfA: 14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BF6_H_SVRH301_1 (THROMBIN, HEAVY CHAIN)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	5 / 11	HIS A 85 LYS A 62 VAL A 65 GLY A 140 GLU A 136	None	1.48A	3bf6H-5xyfA: undetectable	3bf6H-5xyfA: 11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JAY_A_SAMA1102_1 (STRUCTURAL PROTEIN VP3)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	3 / 3	ARG A 52 ASP A 96 ASP A 103	None	0.68A	3jayA-5xyfA: undetectable	3jayA-5xyfA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB2_A_SAMA1102_1 (STRUCTURAL PROTEIN VP3)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	3 / 3	ARG A 52 ASP A 96 ASP A 103	None	0.79A	3jb2A-5xyfA: undetectable	3jb2A-5xyfA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB3_A_SAMA1102_1 (STRUCTURAL PROTEIN VP3)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	3 / 3	ARG A 52 ASP A 96 ASP A 103	None	0.84A	3jb3A-5xyfA: undetectable	3jb3A-5xyfA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_F_URFF301_1 (BIFUNCTIONAL PROTEIN PYRR)	5xyf	TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	3 / 3	ARG A 52 HIS A 53 ARG A 56	None	1.18A	5iaoF-5xyfA: undetectable	5iaoF-5xyfA: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X24_A_LSNA502_1 (CYTOCHROME P450 2C9)	5xyf	ADRENOCORTICAL DYSPLASIA PROTEIN HOMOLOG TERF1-INTERACTING NUCLEAR FACTOR 2 (Homo sapiens)	5 / 12	ALA B 528 PHE A 37 LEU B 529 GLY A 8 LEU A 158	None	1.22A	5x24A-5xyfB: undetectable	5x24A-5xyfB: 6.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WEK_A_DIFA1375_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",3,"LEU A 155;TYR A 154;GLN A 157","None","0.64A","2wekA-5xyfA:undetectable","2wekA-5xyfA:13.99"],["2ZZN_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",5,"LEU A  41;PHE A  14;GLY A   8;ASP A 172;VAL A 173","None","1.28A","2zznA-5xyfA:undetectable","2zznA-5xyfA:undetectable"],["3A2Q_A_ACAA602_1","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",4,"SER A 186;ALA A  18;ALA A  17;ALA A 188","None","0.78A","3a2qA-5xyfA:undetectable","3a2qA-5xyfA:14.16"],["3BF6_H_SVRH301_1","THROMBIN, HEAVY CHAIN","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",5,"HIS A  85;LYS A  62;VAL A  65;GLY A 140;GLU A 136","None","1.48A","3bf6H-5xyfA:undetectable","3bf6H-5xyfA:11.55"],["3JAY_A_SAMA1102_1","STRUCTURAL PROTEIN VP3","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",3,"ARG A  52;ASP A  96;ASP A 103","None","0.68A","3jayA-5xyfA:undetectable","3jayA-5xyfA:undetectable"],["3JB2_A_SAMA1102_1","STRUCTURAL PROTEIN VP3","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",3,"ARG A  52;ASP A  96;ASP A 103","None","0.79A","3jb2A-5xyfA:undetectable","3jb2A-5xyfA:undetectable"],["3JB3_A_SAMA1102_1","STRUCTURAL PROTEIN VP3","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",3,"ARG A  52;ASP A  96;ASP A 103","None","0.84A","3jb3A-5xyfA:undetectable","3jb3A-5xyfA:undetectable"],["5IAO_F_URFF301_1","BIFUNCTIONAL PROTEIN PYRR","5xyf","TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",3,"ARG A  52;HIS A  53;ARG A  56","None","1.18A","5iaoF-5xyfA:undetectable","5iaoF-5xyfA:18.42"],["5X24_A_LSNA502_1","CYTOCHROME P450 2C9","5xyf","ADRENOCORTICAL DYSPLASIA PROTEIN HOMOLOG;TERF1-INTERACTING NUCLEAR FACTOR 2","Homo sapiens",5,"ALA B 528;PHE A  37;LEU B 529;GLY A   8;LEU A 158","None","1.22A","5x24A-5xyfB:undetectable","5x24A-5xyfB:6.62"]]