SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 101
ALA B 102
ILE B 262
ILE B 395
ILE B 280
 None
 0.87A 1hshC-5xyjB:
undetectable		 1hshC-5xyjB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN B  19
LEU B  30
SER B 120
ASN B 123
 None
 1.15A 1ig3A-5xyjB:
undetectable
1ig3B-5xyjB:
undetectable		 1ig3A-5xyjB:
20.42
1ig3B-5xyjB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  15
ALA B  94
GLY B 357
GLY B 257
VAL B  59
 None
 1.14A 2okcA-5xyjB:
undetectable		 2okcA-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  15
ALA B  94
GLY B 357
GLY B 257
VAL B  59
 None
 1.14A 2okcB-5xyjB:
undetectable		 2okcB-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  51
VAL B 268
ASP B  50
VAL B 264
 None
 1.03A 2qbnA-5xyjB:
undetectable		 2qbnA-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER B 359
GLU B 320
SER B 369
GLN B 373
 None
 1.18A 2zvjA-5xyjB:
undetectable		 2zvjA-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL B 363
VAL B 364
GLN B 372
PHE B 319
 None
 1.02A 3bjwH-5xyjB:
undetectable		 3bjwH-5xyjB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL B 363
VAL B 364
GLN B 372
PHE B 319
 None
 0.98A 3bjwF-5xyjB:
undetectable		 3bjwF-5xyjB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 356
GLY B 116
ALA B 259
THR B  13
ILE B  15
 None
 1.20A 3jusB-5xyjB:
undetectable		 3jusB-5xyjB:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 VAL B 264
ALA B 115
TYR B   6
ILE B   7
ILE B 105
 None
 1.24A 3retA-5xyjB:
undetectable
3retB-5xyjB:
undetectable		 3retA-5xyjB:
18.81
3retB-5xyjB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY B 257
VAL B 218
GLY B 116
ALA B 259
ALA B  11
ALA B  38
 None
 1.49A 3sudD-5xyjB:
undetectable		 3sudD-5xyjB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 181
LYS B 188
SER B 189
 None
 1.20A 3tyeB-5xyjB:
undetectable		 3tyeB-5xyjB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 ASN B 344
GLU B 323
ASP B 221
GLU B 201
GLY B 360
 None
 1.46A 4evyA-5xyjB:
undetectable
4evyB-5xyjB:
undetectable		 4evyA-5xyjB:
23.75
4evyB-5xyjB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  55
GLY B 117
GLY B  57
ALA B  69
ALA B  34
 None
 1.05A 4kicB-5xyjB:
undetectable		 4kicB-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL B 112
LEU B  45
ILE B 262
LEU B 263
 None
 0.83A 4mghA-5xyjB:
undetectable		 4mghA-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL B 268
VAL B 264
ILE B  82
PHE B  51
LEU B  45
 None
 1.03A 5e4dB-5xyjB:
undetectable		 5e4dB-5xyjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 101
ALA B 102
ILE B 262
ILE B 395
ILE B 280
 None
 0.82A 5e5kB-5xyjB:
undetectable		 5e5kB-5xyjB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 SER B 391
VAL B 301
TRP B 283
ALA B 304
GLY B 284
 None
 1.09A 5tzoB-5xyjB:
undetectable		 5tzoB-5xyjB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 9 VAL B  72
VAL B 205
ASP B 256
GLY B  16
PRO B  14
 None
 1.37A 5zniA-5xyjB:
undetectable		 5zniA-5xyjB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5xyj ACETYL-COA
ACETYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP B 221
ARG B 362
GLU B 201
GLU B 320
 None
 1.14A 6mn5E-5xyjB:
undetectable		 6mn5E-5xyjB:
25.84