SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 ASP E 111
ASP E  71
LYS E 196
 None
 0.92A 1lqtB-5xykE:
undetectable		 1lqtB-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 ASP E 111
ASP E  71
LYS E 196
 None
 0.94A 1lquB-5xykE:
undetectable		 1lquB-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.46A 1nsiA-5xykE:
undetectable
1nsiB-5xykE:
undetectable		 1nsiA-5xykE:
11.53
1nsiB-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 ARG E  72
ILE E  80
TRP E  65
PHE E  73
 None
None
UDP  E 403 (-4.0A)
None
 1.44A 1nsiC-5xykE:
undetectable
1nsiD-5xykE:
undetectable		 1nsiC-5xykE:
11.53
1nsiD-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.46A 1nsiC-5xykE:
undetectable
1nsiD-5xykE:
undetectable		 1nsiC-5xykE:
11.53
1nsiD-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 VAL E 132
ILE E  78
LEU E 120
ILE E  80
ALA E 240
 None
None
None
None
UDP  E 403 (-3.5A)
 1.15A 2gj5A-5xykE:
undetectable		 2gj5A-5xykE:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE E  81
PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.22A 2no0A-5xykE:
undetectable		 2no0A-5xykE:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE E  81
PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.26A 2no0B-5xykE:
undetectable		 2no0B-5xykE:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE E  81
PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.21A 2noaA-5xykE:
undetectable		 2noaA-5xykE:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 ARG E  72
ILE E  80
TRP E  65
PHE E  73
 None
None
UDP  E 403 (-4.0A)
None
 1.47A 2nsiA-5xykE:
undetectable
2nsiB-5xykE:
undetectable		 2nsiA-5xykE:
11.53
2nsiB-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.44A 2nsiA-5xykE:
undetectable
2nsiB-5xykE:
undetectable		 2nsiA-5xykE:
11.53
2nsiB-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 ARG E  72
ILE E  80
TRP E  65
PHE E  73
 None
None
UDP  E 403 (-4.0A)
None
 1.44A 2nsiC-5xykE:
undetectable
2nsiD-5xykE:
undetectable		 2nsiC-5xykE:
11.53
2nsiD-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.46A 2nsiC-5xykE:
undetectable
2nsiD-5xykE:
undetectable		 2nsiC-5xykE:
11.53
2nsiD-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE E  81
PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.19A 2vppA-5xykE:
undetectable		 2vppA-5xykE:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE E  81
PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.16A 2vppB-5xykE:
undetectable		 2vppB-5xykE:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.42A 3ej8A-5xykE:
undetectable
3ej8B-5xykE:
undetectable		 3ej8A-5xykE:
11.62
3ej8B-5xykE:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 ARG E  72
ILE E  80
TRP E  65
PHE E  73
 None
None
UDP  E 403 (-4.0A)
None
 1.44A 3ej8C-5xykE:
undetectable
3ej8D-5xykE:
undetectable		 3ej8C-5xykE:
11.62
3ej8D-5xykE:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.46A 3ej8C-5xykE:
undetectable
3ej8D-5xykE:
undetectable		 3ej8C-5xykE:
11.62
3ej8D-5xykE:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 8 PHE E 112
GLN E 116
ARG E  72
PHE E  73
 None
 1.10A 3mjrD-5xykE:
undetectable		 3mjrD-5xykE:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.46A 4cx7C-5xykE:
undetectable
4cx7D-5xykE:
undetectable		 4cx7C-5xykE:
11.53
4cx7D-5xykE:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 6 PHE E 313
PHE E 324
ALA E 258
LEU E 285
 None
 0.99A 4ejgD-5xykE:
undetectable		 4ejgD-5xykE:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 5 LEU E 342
SER E 340
LEU E 243
ASN E  91
 None
MN  E 402 (-1.6A)
None
None
 0.98A 4n09C-5xykE:
undetectable		 4n09C-5xykE:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 7 PHE E  73
ARG E  72
ILE E  80
TRP E  65
 None
None
None
UDP  E 403 (-4.0A)
 1.49A 4nosA-5xykE:
undetectable
4nosB-5xykE:
undetectable		 4nosA-5xykE:
11.62
4nosB-5xykE:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		3 / 3 LYS E 176
ASN E 154
ASP E 180
 None
 0.81A 4o1eA-5xykE:
undetectable		 4o1eA-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 LEU E 170
GLY E 173
LYS E 176
GLU E 153
LEU E 152
 None
 1.19A 5nwvA-5xykE:
undetectable		 5nwvA-5xykE:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 5 ASP E 204
ASN E 272
ASP E 239
ARG E  72
 None
ARG  E 401 (-4.3A)
UDP  E 403 ( 3.2A)
None
 1.44A 5vooD-5xykE:
undetectable		 5vooD-5xykE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5xyk PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 LEU E 138
PHE E 210
GLY E 105
ILE E  80
LEU E 120
 None
 1.15A 6dwnC-5xykE:
undetectable		 6dwnC-5xykE:
20.48