SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ALA S  10
 None
 0.98A 1fm9A-5xymS:
undetectable		 1fm9A-5xymS:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA S  61
ALA S  62
LEU S  76
ALA S  10
LEU S  40
 None
 0.89A 1xiuB-5xymS:
undetectable		 1xiuB-5xymS:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ALA S  10
 None
 0.93A 1xiuB-5xymS:
undetectable		 1xiuB-5xymS:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ALA S  10
 None
 1.10A 2aclE-5xymS:
undetectable		 2aclE-5xymS:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ILE S  42
 None
 0.74A 2aclE-5xymS:
undetectable		 2aclE-5xymS:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xym 50S RIBOSOMAL
PROTEIN L3
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY D 203
THR D   9
TYR D  54
ASN D 202
 None
 0.98A 2g70A-5xymD:
undetectable		 2g70A-5xymD:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xym 50S RIBOSOMAL
PROTEIN L3
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY D 203
THR D   9
TYR D  54
ASN D 202
 None
 0.97A 2g70B-5xymD:
undetectable		 2g70B-5xymD:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5xym 50S RIBOSOMAL
PROTEIN L35
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG 3  15
THR 3  49
VAL 3  23
 A  A 728 ( 3.5A)
C  A 747 ( 4.9A)
None
 0.97A 2qakA-5xym3:
undetectable		 2qakA-5xym3:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE S  58
ALA S  61
ALA S  62
ALA S  10
ILE S  42
 None
 0.90A 3fc6A-5xymS:
undetectable		 3fc6A-5xymS:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA S  61
ALA S  62
LEU S  76
ALA S  10
LEU S  40
 None
 0.91A 3h0aA-5xymS:
undetectable		 3h0aA-5xymS:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ILE S  42
 None
 0.66A 3uvvB-5xymS:
undetectable		 3uvvB-5xymS:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5xym 50S RIBOSOMAL
PROTEIN L33 2
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS 1  26
LYS 1   6
PRO 1   8
 None
 1.26A 4dv1L-5xym1:
undetectable		 4dv1L-5xym1:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY C 251
VAL C 247
PRO C 249
GLY C 223
 G  A2466 ( 3.7A)
None
A  A2045 ( 3.9A)
C  A2046 ( 3.3A)
 0.83A 4forA-5xymC:
undetectable		 4forA-5xymC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS C 168
LEU C 165
ALA C 173
 None
 0.68A 4iizA-5xymC:
undetectable		 4iizA-5xymC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG C 258
LYS C 259
LYS C 262
 G  A2019 ( 3.7A)
U  A2311 ( 3.8A)
A  A2023 ( 3.4A)
 1.13A 4k50A-5xymC:
undetectable		 4k50A-5xymC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG C 258
LYS C 259
LYS C 262
 G  A2019 ( 3.7A)
U  A2311 ( 3.8A)
A  A2023 ( 3.4A)
 1.22A 4k50E-5xymC:
undetectable		 4k50E-5xymC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG C 258
LYS C 259
LYS C 262
 G  A2019 ( 3.7A)
U  A2311 ( 3.8A)
A  A2023 ( 3.4A)
 1.22A 4k50I-5xymC:
undetectable		 4k50I-5xymC:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER S   9
GLU S  69
VAL S 112
THR S 111
 None
 1.27A 4lnxA-5xymS:
undetectable		 4lnxA-5xymS:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE S  58
ALA S  61
ALA S  62
ALA S  10
ILE S  42
 None
 1.03A 4nqaH-5xymS:
undetectable		 4nqaH-5xymS:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xym 50S RIBOSOMAL
PROTEIN L2
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA C 173
TYR C 172
PRO C 149
 None
 0.68A 4zdyA-5xymC:
undetectable		 4zdyA-5xymC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA S  61
ALA S  62
LEU S  76
ALA S  10
LEU S  40
 None
 0.93A 5z12B-5xymS:
undetectable		 5z12B-5xymS:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA S  61
ALA S  62
LEU S  76
ALA S  10
LEU S  40
 None
 0.96A 6a60D-5xymS:
undetectable		 6a60D-5xymS:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xym 50S RIBOSOMAL
PROTEIN L22
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE S  58
ALA S  61
ALA S  62
LEU S  76
ALA S  10
ILE S  42
 None
 1.16A 6a60D-5xymS:
undetectable		 6a60D-5xymS:
25.95