SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 182
THR A 209
PRO A 181
 None
 0.80A 1a7yA-5xynA:
undetectable		 1a7yA-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 182
THR A 209
PRO A 181
 None
 0.85A 1a7yB-5xynA:
undetectable		 1a7yB-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 VAL C  55
VAL C  51
TRP C  15
 None
 0.83A 1av2C-5xynC:
undetectable
1av2D-5xynC:
undetectable		 1av2C-5xynC:
9.76
1av2D-5xynC:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5xyn SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		5 / 11 CYH D 116
HIS D 178
LEU D 186
CYH D 176
ILE D 109
 ZN  D 301 (-2.3A)
ZN  D 301 (-3.2A)
None
ZN  D 301 (-2.3A)
None
 1.22A 1ee2A-5xynD:
undetectable		 1ee2A-5xynD:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5xyn SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		5 / 11 CYH D 116
HIS D 178
LEU D 186
CYH D 176
ILE D 109
 ZN  D 301 (-2.3A)
ZN  D 301 (-3.2A)
None
ZN  D 301 (-2.3A)
None
 1.23A 1ee2B-5xynD:
undetectable		 1ee2B-5xynD:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		3 / 3 GLN C 108
ILE C 149
HIS D 111
 None
 0.72A 1fm9A-5xynC:
undetectable		 1fm9A-5xynC:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		3 / 3 GLN C 108
ILE C 149
HIS D 111
 None
 0.68A 1k74A-5xynC:
undetectable		 1k74A-5xynC:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 HIS C  45
THR A  17
GLY C  41
GLN C   8
ASN A  21
 None
 1.28A 1n2xA-5xynC:
3.4		 1n2xA-5xynC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 170
MET A 115
ARG C  58
VAL C  51
 None
 1.44A 1p6kA-5xynA:
0.1
1p6kB-5xynA:
undetectable		 1p6kA-5xynA:
19.47
1p6kB-5xynA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 182
THR A 209
PRO A 181
 None
 0.80A 1qfiA-5xynA:
undetectable		 1qfiA-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 215
LEU A 141
LEU A 107
ILE A 175
LEU A 211
 None
 1.22A 1tw4B-5xynA:
undetectable		 1tw4B-5xynA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 215
LEU A 160
LEU A 107
ILE A 175
LEU A 211
 None
 1.13A 1tw4B-5xynA:
undetectable		 1tw4B-5xynA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 209
PRO A 181
THR A 182
 None
 0.85A 1unjF-5xynA:
undetectable		 1unjF-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 182
THR A 209
PRO A 181
 None
 0.79A 1unjF-5xynA:
undetectable		 1unjF-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 182
THR A 209
PRO A 181
 None
 0.85A 1unjX-5xynA:
undetectable		 1unjX-5xynA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 215
PHE A 161
ILE A 133
ILE A  73
THR A 177
 None
 1.29A 2bjfA-5xynA:
undetectable		 2bjfA-5xynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU C  42
ILE A  16
VAL C  24
VAL C  26
PRO A  11
 None
 1.05A 2ygpA-5xynC:
undetectable		 2ygpA-5xynC:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  60
ILE A 222
ILE A 223
MET A 216
LEU A 138
 None
 1.26A 3gwxA-5xynA:
undetectable		 3gwxA-5xynA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  60
ILE A 222
MET A 216
LEU A 138
TYR A 215
 None
 1.18A 3gwxA-5xynA:
undetectable		 3gwxA-5xynA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 VAL C  55
VAL C  51
TRP C  15
 None
 0.77A 3l8lA-5xynC:
undetectable
3l8lB-5xynC:
undetectable		 3l8lA-5xynC:
9.76
3l8lB-5xynC:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5xyn SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		5 / 12 TYR D  33
PHE D  36
ALA D  44
LEU D  48
LEU D 179
 None
 1.28A 3lcvB-5xynD:
undetectable		 3lcvB-5xynD:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 220
GLU A 169
SER A  34
 None
 0.85A 3p2kA-5xynA:
undetectable		 3p2kA-5xynA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 VAL C  51
LEU A 130
PHE A 126
ILE A 133
LEU A 164
 None
 1.32A 3w67D-5xynC:
undetectable		 3w67D-5xynC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR C  94
ASP C  98
ASP C  31
 None
 0.86A 4a6eA-5xynC:
undetectable		 4a6eA-5xynC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 VAL C  37
GLY C  40
LYS C  43
 None
 0.75A 4k50I-5xynC:
undetectable		 4k50I-5xynC:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL C  24
LEU A  12
LEU C  10
LEU C   7
PHE C   3
 None
 1.15A 4zmeA-5xynC:
undetectable		 4zmeA-5xynC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 VAL C  24
LEU A  12
LEU C  10
LEU C   7
PHE C   3
 None
 1.16A 4zmeB-5xynC:
undetectable		 4zmeB-5xynC:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A   2
GLY C  30
ASP C  31
ARG C  34
 None
 0.87A 5cdnC-5xynA:
undetectable
5cdnD-5xynA:
undetectable		 5cdnC-5xynA:
20.37
5cdnD-5xynA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A   2
GLY C  30
ASP C  31
ARG C  34
 None
 0.85A 5cdnT-5xynA:
undetectable
5cdnU-5xynA:
undetectable		 5cdnT-5xynA:
20.37
5cdnU-5xynA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		5 / 12 GLU D 117
PHE C 144
ILE C 148
LEU D 179
HIS D 178
 None
None
None
None
ZN  D 301 (-3.2A)
 1.23A 5esgA-5xynD:
undetectable		 5esgA-5xynD:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2
(Saccharomyces
cerevisiae) 		4 / 5 LEU C 114
CYH D 176
LEU D 179
ASP D 108
 None
ZN  D 301 (-2.3A)
None
None
 1.37A 5mafA-5xynC:
undetectable		 5mafA-5xynC:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 103
GLY A 102
SER A  96
SER A  94
 None
 1.32A 5uunA-5xynA:
undetectable		 5uunA-5xynA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 103
GLY A 102
SER A  96
SER A  94
 None
 1.26A 5uunB-5xynA:
undetectable		 5uunB-5xynA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  57
ILE A  78
HIS A  45
LEU A 211
TYR A 215
 None
 1.21A 5ycpA-5xynA:
undetectable		 5ycpA-5xynA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  47
HIS A  45
VAL A  76
SER A 139
PRO A  53
 None
 1.50A 5z0mA-5xynA:
undetectable
5z0mB-5xynA:
undetectable		 5z0mA-5xynA:
16.88
5z0mB-5xynA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xyn PLATINUM SENSITIVITY
PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 135
LEU A 138
ARG A 168
MET A 219
 None
 1.14A 6nmfN-5xynA:
undetectable
6nmfW-5xynA:
undetectable		 6nmfN-5xynA:
20.47
6nmfW-5xynA:
17.30