SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 5 ARG A 364
ASP A 213
SER A 199
SER A 368
 A9Y  A 602 (-3.5A)
None
None
None
 1.49A 1kiaB-5xzbA:
undetectable		 1kiaB-5xzbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 7 GLU A 479
LEU A 480
THR A 231
LYS A 472
 None
 1.07A 1rmtB-5xzbA:
undetectable		 1rmtB-5xzbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 8 LYS A 409
THR A 295
SER A 420
GLU A 371
 None
 1.41A 1xr2B-5xzbA:
undetectable		 1xr2B-5xzbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		3 / 3 THR A 197
LYS A 409
GLU A 202
 None
 0.85A 3ijdB-5xzbA:
undetectable		 3ijdB-5xzbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		3 / 3 THR A 197
LYS A 409
GLU A 371
 None
 0.97A 3ijdB-5xzbA:
undetectable		 3ijdB-5xzbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 5 GLU A 202
GLU A 371
TYR A 421
HIS A 422
 None
None
A9Y  A 602 (-4.0A)
A9Y  A 602 ( 4.5A)
 1.45A 4a97J-5xzbA:
undetectable		 4a97J-5xzbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		3 / 3 ARG A 158
TYR A 201
ASN A 376
 None
 0.90A 4ffwB-5xzbA:
undetectable		 4ffwB-5xzbA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		5 / 12 CYH A 459
PHE A 456
LEU A 480
ILE A 481
LEU A 489
 None
 1.28A 4k38B-5xzbA:
undetectable		 4k38B-5xzbA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 7 ILE A 223
LEU A 225
GLY A 316
LYS A 315
 None
 0.89A 4z69A-5xzbA:
undetectable		 4z69A-5xzbA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		3 / 3 VAL A 220
LYS A 190
MET A 182
 None
 1.06A 5nknA-5xzbA:
undetectable		 5nknA-5xzbA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		3 / 3 LYS A 350
PRO A 292
LYS A 288
 None
 1.27A 5y9yA-5xzbA:
undetectable		 5y9yA-5xzbA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 4 ILE A 493
LEU A 452
HIS A 422
ALA A 426
 None
None
A9Y  A 602 ( 4.5A)
None
 0.99A 6ck2C-5xzbA:
undetectable
6ck2D-5xzbA:
undetectable		 6ck2C-5xzbA:
3.71
6ck2D-5xzbA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		5 / 9 ASN A 196
ILE A 304
GLU A 273
VAL A 282
ILE A 298
 None
 1.44A 6hloA-5xzbA:
undetectable		 6hloA-5xzbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5xzb CYCLIC GMP-AMP
SYNTHASE
(Mus
musculus) 		4 / 5 GLY A 325
THR A 322
HIS A 467
SER A 366
 None
None
A9Y  A 602 (-4.1A)
None
 1.11A 6jmjA-5xzbA:
undetectable		 6jmjA-5xzbA:
19.06