SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		5 / 12 LEU A 107
CYH A 111
LEU A 113
ALA A 114
PHE A 128
 None
 1.30A 1s9pB-5xzdA:
undetectable		 1s9pB-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		5 / 12 THR A  18
LEU A  19
ILE A   6
ASN A  29
LEU A 113
 None
 1.29A 1wsvA-5xzdA:
undetectable		 1wsvA-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		5 / 12 THR A  18
LEU A  19
ILE A   6
ASN A  29
LEU A 113
 None
 1.31A 1wsvB-5xzdA:
undetectable		 1wsvB-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		5 / 12 GLU A 132
ALA A  27
GLY A 129
GLY A 108
ASP A 158
 ACY  A 301 (-3.5A)
None
None
ACY  A 301 ( 4.5A)
None
 0.99A 1x1aA-5xzdA:
undetectable		 1x1aA-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		3 / 3 MET A 115
GLU A 132
ASN A 134
 None
ACY  A 301 (-3.5A)
None
 1.04A 3a27A-5xzdA:
undetectable		 3a27A-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		5 / 12 LEU A 113
GLY A  56
SER A  57
LEU A  28
LEU A  33
 None
 1.16A 3cjtG-5xzdA:
undetectable		 3cjtG-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		5 / 12 LEU A  19
ILE A  54
ALA A 100
GLY A 129
ALA A  62
 None
 1.10A 4enhA-5xzdA:
undetectable		 4enhA-5xzdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5xzd ENOYL-COA HYDRATASE
(Roseovarius
nubinhibens) 		4 / 7 ILE A 120
LEU A 176
ALA A 114
ALA A 126
 None
 0.65A 4g77A-5xzdA:
undetectable		 4g77A-5xzdA:
undetectable