SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 227
VAL A 247
VAL A 257
LEU A 326
 None
 0.92A 1iepB-5xzwA:
19.2		 1iepB-5xzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 315
ALA A 343
LEU A 248
ILE A 337
ILE A 310
 None
 1.21A 1rb3A-5xzwA:
undetectable		 1rb3A-5xzwA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 196
PHE A 224
ASN A 121
 None
 0.82A 1sg9B-5xzwA:
undetectable		 1sg9B-5xzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 324
HIS A 317
PHE A 340
ILE A 303
 None
 1.26A 1tdnA-5xzwA:
undetectable		 1tdnA-5xzwA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 212
VAL A 247
ILE A 256
ILE A 315
 None
 0.78A 1uwhA-5xzwA:
20.5		 1uwhA-5xzwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 ALA A 225
GLY A 279
ASP A 283
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.06A 1xkkA-5xzwA:
18.7		 1xkkA-5xzwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
VAL A 276
ASP A 319
LYS A 321
ASN A 324
ASP A 339
 None
 0.86A 2fumA-5xzwA:
22.0		 2fumA-5xzwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 212
ALA A 225
GLU A 244
PHE A 275
GLY A 279
LEU A 326
 None
 0.82A 2hyyA-5xzwA:
19.4		 2hyyA-5xzwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 212
ALA A 225
GLU A 244
PHE A 275
GLY A 279
LEU A 326
 None
 0.80A 2hyyB-5xzwA:
19.3		 2hyyB-5xzwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 130
LEU A 101
THR A 106
VAL A 134
LEU A  78
 None
 1.24A 3a51A-5xzwA:
undetectable		 3a51A-5xzwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
GLY A 279
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.04A 3bbtB-5xzwA:
18.9		 3bbtB-5xzwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
LEU A 248
GLY A 279
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.32A 3bbtB-5xzwA:
18.9		 3bbtB-5xzwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 ALA A 225
LYS A 227
GLY A 279
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.25A 3bbtD-5xzwA:
19.0		 3bbtD-5xzwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
GLY A 279
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.01A 3bbtD-5xzwA:
19.0		 3bbtD-5xzwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 212
ALA A 225
GLU A 244
LEU A 248
ILE A 310
 None
 0.85A 3gcsA-5xzwA:
17.9		 3gcsA-5xzwA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 204
ALA A 225
LYS A 227
GLU A 244
LEU A 248
 None
 0.63A 3hecA-5xzwA:
18.2		 3hecA-5xzwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 204
VAL A 212
ALA A 225
LYS A 227
GLU A 244
LEU A 248
ILE A 310
 None
 0.82A 3hegA-5xzwA:
17.5		 3hegA-5xzwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 212
LYS A 227
VAL A 247
VAL A 257
 None
 0.75A 3mssD-5xzwA:
18.9		 3mssD-5xzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 204
GLY A 205
VAL A 212
ALA A 225
LYS A 227
LEU A 248
 None
 0.60A 3ohtA-5xzwA:
15.4		 3ohtA-5xzwA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 315
ALA A 343
LEU A 248
ILE A 337
ILE A 310
 None
 1.19A 3ql3A-5xzwA:
undetectable		 3ql3A-5xzwA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 ALA A 225
LYS A 227
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.86A 3ue4A-5xzwA:
20.8		 3ue4A-5xzwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.80A 3ue4B-5xzwA:
20.4		 3ue4B-5xzwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 227
VAL A 257
LEU A 326
ASP A 339
 None
 0.73A 3wzdA-5xzwA:
18.7		 3wzdA-5xzwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 ALA A 225
LYS A 227
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.74A 4ag8A-5xzwA:
19.1		 4ag8A-5xzwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
LYS A 227
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.71A 4ag8A-5xzwA:
19.1		 4ag8A-5xzwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 225
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.55A 4agdA-5xzwA:
18.6		 4agdA-5xzwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 248
ASP A 319
LYS A 321
ASN A 324
ASP A 339
 None
 0.70A 4an2A-5xzwA:
19.4		 4an2A-5xzwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		8 / 12 VAL A 212
ALA A 225
LYS A 227
GLU A 244
LEU A 248
PHE A 275
GLY A 279
HIS A 317
 None
 0.86A 4asdA-5xzwA:
19.1		 4asdA-5xzwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 ALA A 225
LYS A 227
GLU A 244
LEU A 248
ILE A 256
HIS A 317
LEU A 326
 None
 0.79A 4c8bB-5xzwA:
19.2		 4c8bB-5xzwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 225
GLU A 202
GLY A 221
ASN A  98
GLU A 274
 None
 1.38A 4j83A-5xzwA:
undetectable		 4j83A-5xzwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 225
GLU A 202
GLY A 221
ASN A  98
GLU A 274
 None
 1.47A 4jdsD-5xzwA:
undetectable		 4jdsD-5xzwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 10 ALA A 225
VAL A 257
MET A 273
PHE A 275
GLY A 279
LEU A 326
ASP A 339
 None
 0.84A 4ks8A-5xzwA:
21.8		 4ks8A-5xzwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 10 VAL A 212
GLU A 244
LEU A 251
ILE A 256
VAL A 257
ILE A 337
 None
 0.90A 4u0iA-5xzwA:
19.2		 4u0iA-5xzwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
LYS A 227
PHE A 275
GLY A 279
ASN A 324
LEU A 326
 None
 0.88A 4wa9B-5xzwA:
19.3		 4wa9B-5xzwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 205
GLY A 207
VAL A 212
LYS A 227
 None
 0.47A 5j5xA-5xzwA:
22.4		 5j5xA-5xzwA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 10 VAL A 212
ALA A 225
VAL A 257
MET A 273
VAL A 276
LEU A 326
THR A 338
 None
 0.87A 5n3hA-5xzwA:
22.5		 5n3hA-5xzwA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 GLU A 202
ALA A 225
GLU A 244
VAL A 257
PHE A 275
GLY A 279
LEU A 326
 None
 0.81A 5te0A-5xzwA:
21.2		 5te0A-5xzwA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 205
VAL A 212
ALA A 225
LEU A 326
THR A 338
ASP A 339
 None
 0.75A 5yu9B-5xzwA:
18.7		 5yu9B-5xzwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 212
ALA A 225
GLY A 279
ASP A 283
THR A 338
ASP A 339
 None
 0.86A 5yu9C-5xzwA:
18.5		 5yu9C-5xzwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
GLY A 279
ASP A 283
LEU A 326
THR A 338
ASP A 339
 None
 0.84A 5yu9D-5xzwA:
18.8		 5yu9D-5xzwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 227
LEU A 326
ASP A 339
 None
 0.91A 5zv2A-5xzwA:
18.4		 5zv2A-5xzwA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
LYS A 227
GLU A 244
VAL A 257
PHE A 275
LEU A 326
 None
 0.88A 6hd6A-5xzwA:
12.2		 6hd6A-5xzwA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 212
ALA A 225
LYS A 227
GLU A 244
VAL A 257
PHE A 275
LEU A 326
 None
 0.92A 6hd6B-5xzwA:
18.8		 6hd6B-5xzwA:
11.19