SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 PHE A 162
LEU A 123
ALA A 136
ALA A 180
THR A 150
 None
 1.03A 1cbsA-5xzxA:
undetectable		 1cbsA-5xzxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 CYH A 122
LEU A 123
ALA A 135
LEU A 139
ALA A  80
 None
 1.03A 1sa1A-5xzxA:
undetectable
1sa1B-5xzxA:
undetectable		 1sa1A-5xzxA:
23.66
1sa1B-5xzxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 PHE A 162
LEU A 123
ALA A 136
ALA A 180
THR A 150
 None
 1.04A 2fr3A-5xzxA:
undetectable		 2fr3A-5xzxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 LEU A 369
ALA A 346
GLY A 309
VAL A 364
LEU A 350
 None
 1.26A 3ogpB-5xzxA:
undetectable		 3ogpB-5xzxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 11 SER A 113
GLY A 114
ILE A 107
LEU A  99
ILE A 142
 None
 0.98A 4dt8A-5xzxA:
undetectable		 4dt8A-5xzxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 LEU A 181
SER A 197
ILE A 196
LEU A 227
THR A 150
 None
 1.11A 4ky8C-5xzxA:
undetectable		 4ky8C-5xzxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 LEU A 181
SER A 197
ILE A 196
LEU A 227
THR A 150
 None
 1.13A 4qi9B-5xzxA:
undetectable		 4qi9B-5xzxA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		3 / 3 VAL A  92
GLN A 132
CYH A 122
 None
 0.79A 5icxA-5xzxA:
undetectable
5icxE-5xzxA:
undetectable		 5icxA-5xzxA:
18.95
5icxE-5xzxA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens) 		3 / 3 VAL A  92
GLN A 132
CYH A 122
 None
 0.82A 5icxC-5xzxA:
undetectable
5icxF-5xzxA:
undetectable		 5icxC-5xzxA:
18.95
5icxF-5xzxA:
2.96