SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5y05 MSMEG_4306
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  31
ASN A  30
LEU A 159
ALA A 162
ILE A  24
 None
 0.95A 1fk6A-5y05A:
undetectable		 1fk6A-5y05A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5y05 MSMEG_4306
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A  11
VAL A 182
TYR A 185
ARG A 170
 None
 1.37A 1nw3A-5y05A:
undetectable		 1nw3A-5y05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5y05 MSMEG_4306
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 238
PRO A 198
LEU A 237
ARG A 229
 None
 1.01A 2hrcA-5y05A:
undetectable		 2hrcA-5y05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5y05 MSMEG_4306
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 131
LEU A 135
GLU A 134
 None
 0.74A 4l3gF-5y05A:
undetectable		 4l3gF-5y05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5y05 MSMEG_4306
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ILE A  72
LEU A 117
MET A 121
LEU A 118
 None
 0.85A 5u4sB-5y05A:
undetectable		 5u4sB-5y05A:
undetectable