SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 PHE A 457
SER A 508
ALA A 455
ILE A 572
 None
 1.02A 1fxhA-5y09A:
undetectable
1fxhB-5y09A:
undetectable		 1fxhA-5y09A:
17.25
1fxhB-5y09A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ILE A 314
LEU A 267
ASP A 222
GLY A 221
PHE A 220
 None
 0.91A 1hvyD-5y09A:
undetectable		 1hvyD-5y09A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 9 PHE A 382
ILE A 379
ASP A 390
GLY A 391
PHE A 403
 None
 1.47A 1i00B-5y09A:
undetectable		 1i00B-5y09A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 PHE A 157
ILE A 201
ILE A 292
ILE A 273
ILE A 309
 None
 1.23A 1r5lA-5y09A:
undetectable		 1r5lA-5y09A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 PHE A 330
TYR A 327
THR A 412
TYR A 411
 None
 1.19A 1rmtB-5y09A:
undetectable		 1rmtB-5y09A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 VAL A 171
TYR A 257
CYH A 199
ARG A 162
 None
 1.20A 1t46A-5y09A:
undetectable		 1t46A-5y09A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 5 ALA A 293
ASN A 167
ILE A 201
ASP A 200
 None
 1.03A 1yc2D-5y09A:
undetectable		 1yc2D-5y09A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ILE A 292
VAL A 131
LEU A 204
ALA A 127
PHE A 157
 None
 1.39A 2jj8C-5y09A:
undetectable		 2jj8C-5y09A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 11 LEU A 499
THR A 460
ILE A 440
LEU A 506
VAL A 458
 None
 1.46A 2n27A-5y09A:
undetectable		 2n27A-5y09A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		6 / 10 ILE A 195
LEU A 165
ALA A 168
VAL A 177
VAL A 192
VAL A 131
 None
 1.41A 2nnjA-5y09A:
undetectable		 2nnjA-5y09A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 6 GLN A 498
ASN A 532
ASN A 519
LEU A 483
 None
 1.28A 2nyrA-5y09A:
undetectable		 2nyrA-5y09A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 ILE A 314
ASP A 222
GLY A 221
PHE A 220
 None
 0.90A 2tsrA-5y09A:
undetectable		 2tsrA-5y09A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 GLY A 384
LEU A 406
ASP A 383
ALA A 416
SER A 415
 None
 1.23A 3d91B-5y09A:
undetectable		 3d91B-5y09A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.07A 3ln1A-5y09A:
undetectable		 3ln1A-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.07A 3ln1B-5y09A:
undetectable		 3ln1B-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.07A 3ln1C-5y09A:
undetectable		 3ln1C-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.06A 3ln1D-5y09A:
undetectable		 3ln1D-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 VAL A 558
LEU A 560
LEU A 552
VAL A 454
GLY A 456
 None
 1.07A 3nt1A-5y09A:
undetectable		 3nt1A-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 VAL A 558
LEU A 560
LEU A 552
VAL A 454
GLY A 456
 None
 1.07A 3nt1B-5y09A:
undetectable		 3nt1B-5y09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 VAL A 558
LEU A 560
LEU A 552
VAL A 454
GLY A 456
 None
 1.03A 3rr3C-5y09A:
undetectable		 3rr3C-5y09A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 VAL A 558
LEU A 560
LEU A 552
VAL A 454
GLY A 456
 None
 1.02A 3rr3D-5y09A:
undetectable		 3rr3D-5y09A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 6 SER A 508
ASP A 509
THR A 569
ILE A 572
 None
 1.06A 4acbC-5y09A:
2.9		 4acbC-5y09A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 11 ILE A 314
LEU A 265
ASP A 222
GLY A 221
PHE A 220
 None
 1.35A 4fogA-5y09A:
undetectable		 4fogA-5y09A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 ILE A 314
ASP A 222
GLY A 221
PHE A 220
 None
 0.82A 4iqqC-5y09A:
undetectable		 4iqqC-5y09A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ILE A 387
PHE A 403
ILE A 335
LEU A 333
ILE A 379
 None
 1.10A 4kjkA-5y09A:
undetectable		 4kjkA-5y09A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ILE A 292
ALA A 282
ILE A 269
LEU A 255
ILE A 309
 None
 1.03A 4km0B-5y09A:
undetectable		 4km0B-5y09A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 VAL A 164
ILE A 242
GLY A 280
ILE A 292
SER A 155
 None
 1.03A 4mwzB-5y09A:
undetectable		 4mwzB-5y09A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 293
PRO A 281
GLY A 279
GLY A 156
LEU A 165
 None
 1.07A 5c0oH-5y09A:
undetectable		 5c0oH-5y09A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 GLY A 280
PRO A 281
VAL A 232
PHE A 157
LEU A 165
 None
 1.34A 5jo9A-5y09A:
undetectable		 5jo9A-5y09A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.09A 5jw1B-5y09A:
undetectable		 5jw1B-5y09A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.08A 5kirA-5y09A:
undetectable		 5kirA-5y09A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 12 ALA A 565
VAL A 540
GLY A 538
ALA A 537
LEU A 586
 None
 1.11A 5kirB-5y09A:
undetectable		 5kirB-5y09A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 ILE A 314
ASP A 222
GLY A 221
PHE A 220
 None
 0.86A 5nooA-5y09A:
undetectable		 5nooA-5y09A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		4 / 7 ILE A 314
ASP A 222
GLY A 221
PHE A 220
 None
 0.89A 5x5qC-5y09A:
undetectable		 5x5qC-5y09A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEE_B_RXMB601_0
(SCAFFOLD PROTEIN D13)		 5y09 PROTEASE DO-LIKE 9
(Arabidopsis
thaliana) 		5 / 9 PHE A 220
PHE A 157
VAL A 177
PHE A 317
VAL A 218
 None
 1.23A 6beeA-5y09A:
0.0
6beeB-5y09A:
0.0
6beeC-5y09A:
0.0		 6beeA-5y09A:
22.66
6beeB-5y09A:
22.66
6beeC-5y09A:
22.66