SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5y0e -
(-) 		3 / 3 SER A 249
TYR A 252
HIS A 250
 None
None
SO4  A 501 (-4.4A)
 0.82A 2r2vD-5y0eA:
undetectable		 2r2vD-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5y0e -
(-) 		5 / 9 LEU A 358
LEU A 387
PHE A 406
TYR A 405
THR A 404
 None
 1.43A 4ltwA-5y0eA:
undetectable		 4ltwA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5y0e -
(-) 		4 / 5 GLN A  57
THR A  53
THR A 169
LEU A 153
 None
 1.38A 4lvcA-5y0eA:
undetectable		 4lvcA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5y0e -
(-) 		4 / 5 GLN A  57
THR A  53
THR A 169
LEU A 153
 None
 1.38A 4lvcC-5y0eA:
undetectable		 4lvcC-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y0e -
(-) 		4 / 4 GLN A  57
THR A  53
THR A 169
LEU A 153
 None
 1.37A 5m5kA-5y0eA:
undetectable		 5m5kA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y0e -
(-) 		4 / 4 GLN A  57
THR A  53
THR A 169
LEU A 153
 None
 1.36A 5m5kC-5y0eA:
undetectable		 5m5kC-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5y0e -
(-) 		4 / 5 LEU A 301
CYH A 193
LEU A 257
ASP A 265
 None
None
SO4  A 501 (-4.1A)
SO4  A 501 (-3.9A)
 1.33A 5mafA-5y0eA:
undetectable		 5mafA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5y0e -
(-) 		4 / 5 GLN A  57
THR A  53
THR A 169
LEU A 153
 None
 1.39A 6gbnA-5y0eA:
undetectable		 6gbnA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5y0e -
(-) 		4 / 5 GLN A  57
THR A  53
THR A 169
LEU A 153
 None
 1.40A 6gbnD-5y0eA:
undetectable		 6gbnD-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5y0e -
(-) 		3 / 3 ASN A 196
PRO A 188
GLN A 186
 None
 0.82A 6jnhA-5y0eA:
undetectable		 6jnhA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5y0e -
(-) 		3 / 3 ASN A 196
PRO A 188
GLN A 186
 None
 0.80A 6jogA-5y0eA:
undetectable		 6jogA-5y0eA:
undetectable