SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5y0m -
(-) 		4 / 6 GLY A  71
TYR A 156
ALA A 116
TYR A  65
 None
 0.97A 1dmaB-5y0mA:
undetectable		 1dmaB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5y0m -
(-) 		5 / 12 ALA A  81
ILE A 269
THR A 309
LEU A 310
LEU A 283
 None
 1.32A 1eiiA-5y0mA:
undetectable		 1eiiA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5y0m -
(-) 		5 / 11 THR A  73
ALA A 353
ASP A 348
ALA A 203
PRO A 218
 None
None
GOL  A1002 ( 4.6A)
None
None
 1.26A 2admA-5y0mA:
undetectable		 2admA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5y0m -
(-) 		5 / 10 ALA A 165
ALA A  63
VAL A  74
GLY A 119
ALA A 116
 None
 0.98A 2f16K-5y0mA:
undetectable
2f16L-5y0mA:
undetectable		 2f16K-5y0mA:
undetectable
2f16L-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5y0m -
(-) 		5 / 10 ALA A 165
ALA A  63
VAL A  74
GLY A 119
ALA A 116
 None
 0.98A 2f16Y-5y0mA:
undetectable
2f16Z-5y0mA:
undetectable		 2f16Y-5y0mA:
undetectable
2f16Z-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 12 GLN A 176
LEU A 106
VAL A  58
ALA A 203
VAL A 273
 None
 1.41A 2g70B-5y0mA:
undetectable		 2g70B-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 12 ALA A 185
ALA A 150
GLY A  71
GLY A 182
TYR A 112
 None
 1.11A 2igtA-5y0mA:
undetectable		 2igtA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 12 PHE A 174
ALA A 116
ALA A 165
GLY A 108
GLY A 113
 None
 1.08A 2igtA-5y0mA:
undetectable		 2igtA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 12 ALA A 185
ALA A 150
GLY A  71
GLY A 182
TYR A 112
 None
 1.12A 2igtB-5y0mA:
undetectable		 2igtB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 12 PHE A 174
ALA A 116
ALA A 165
GLY A 108
GLY A 113
 None
 1.08A 2igtB-5y0mA:
undetectable		 2igtB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 12 TYR A 146
ALA A 185
SER A 186
GLY A 182
TYR A 112
 GOL  A1006 ( 4.8A)
None
CL  A1008 ( 4.5A)
None
None
 1.24A 2igtC-5y0mA:
undetectable		 2igtC-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5y0m -
(-) 		4 / 8 ALA A 110
SER A 142
GLY A 117
ALA A 107
 GOL  A1003 (-3.5A)
None
None
None
 0.73A 2vh3B-5y0mA:
undetectable		 2vh3B-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 5y0m -
(-) 		5 / 10 ALA A 181
GLY A 199
ILE A 197
PRO A 220
THR A 267
 None
None
None
None
GOL  A1003 ( 3.2A)
 1.13A 3el5A-5y0mA:
undetectable		 3el5A-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5y0m -
(-) 		5 / 12 THR A 315
LEU A 213
ILE A 104
ILE A  75
LEU A 283
 None
 1.33A 3gwxA-5y0mA:
undetectable		 3gwxA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5y0m -
(-) 		5 / 12 GLY A  68
ARG A  44
GLY A 108
ALA A  63
ALA A 165
 None
 1.07A 3sufA-5y0mA:
undetectable		 3sufA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5y0m -
(-) 		5 / 12 GLY A 180
ALA A 181
ILE A 269
ILE A  60
VAL A 217
 None
 1.04A 3ucbA-5y0mA:
undetectable		 3ucbA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5y0m -
(-) 		4 / 7 GLY A  71
TYR A 156
ALA A 116
GLU A 115
 None
 0.93A 4hyfA-5y0mA:
undetectable		 4hyfA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5y0m -
(-) 		4 / 8 GLY A 111
GLY A 108
ILE A 145
LEU A 106
 GOL  A1003 (-4.2A)
None
None
None
 0.79A 4mwzB-5y0mA:
undetectable		 4mwzB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5y0m -
(-) 		5 / 11 GLY A  71
TYR A 156
ALA A 116
TYR A  65
GLU A 115
 None
 1.12A 4rv6A-5y0mA:
undetectable		 4rv6A-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5y0m -
(-) 		5 / 11 GLY A  71
TYR A 156
ALA A 116
TYR A  65
GLU A 115
 None
 1.12A 4rv6B-5y0mA:
undetectable		 4rv6B-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5y0m -
(-) 		5 / 9 GLY A 199
ILE A 298
MET A 294
VAL A 217
THR A 268
 None
 1.44A 4x3mA-5y0mA:
undetectable		 4x3mA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5y0m -
(-) 		5 / 11 ASP A 158
ALA A 181
TYR A  65
GLY A 117
GLY A 108
 None
 1.18A 4xnxA-5y0mA:
undetectable		 4xnxA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5y0m -
(-) 		5 / 12 LEU A 283
LEU A 338
ILE A 272
ALA A 312
ILE A 212
 None
 1.22A 5eypB-5y0mA:
undetectable		 5eypB-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5y0m -
(-) 		5 / 10 ASP A 158
ALA A 181
GLY A 117
GLY A 108
VAL A  74
 None
 1.08A 5i6xA-5y0mA:
undetectable		 5i6xA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5y0m -
(-) 		5 / 12 SER A  59
VAL A  74
ALA A  63
PRO A  78
GLY A  61
 None
 1.24A 5tzoC-5y0mA:
undetectable		 5tzoC-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5y0m -
(-) 		5 / 12 GLY A 199
PRO A 220
ALA A 187
VAL A 215
PHE A 174
 None
 1.29A 5x6yA-5y0mA:
undetectable		 5x6yA-5y0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 5y0m -
(-) 		3 / 3 SER A 141
ALA A 143
VAL A 144
 None
None
GOL  A1003 (-4.8A)
 0.54A 5xiwC-5y0mA:
undetectable		 5xiwC-5y0mA:
undetectable