SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.88A 11gsA-5y0qA:
undetectable		 11gsA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		5 / 9 LEU A 254
SER A 257
THR A 260
VAL A 261
LEU A 266
 None
 1.49A 1fo4A-5y0qA:
undetectable		 1fo4A-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.85A 2gssA-5y0qA:
undetectable		 2gssA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.85A 2gssB-5y0qA:
undetectable		 2gssB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 5 ILE A 210
PRO A  12
PHE A  13
ILE A 204
 None
None
None
APC  A1001 (-4.0A)
 0.93A 2hjhA-5y0qA:
undetectable		 2hjhA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.88A 3gssA-5y0qA:
undetectable		 3gssA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.89A 3gssB-5y0qA:
undetectable		 3gssB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.79A 3hjoA-5y0qA:
undetectable		 3hjoA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		5 / 12 PRO A 358
SER A 365
LEU A 355
ILE A 335
SER A 361
 None
 1.48A 3iltB-5y0qA:
undetectable
3iltE-5y0qA:
undetectable		 3iltB-5y0qA:
undetectable
3iltE-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		5 / 10 ILE A 335
SER A 361
PRO A 358
SER A 365
LEU A 355
 None
 1.46A 3iltB-5y0qA:
undetectable
3iltE-5y0qA:
undetectable		 3iltB-5y0qA:
undetectable
3iltE-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.83A 3kmoB-5y0qA:
undetectable		 3kmoB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 SER A 240
PHE A 393
SER A  51
LEU A 338
 None
 1.02A 3m0wE-5y0qA:
undetectable
3m0wF-5y0qA:
undetectable
3m0wG-5y0qA:
undetectable
3m0wH-5y0qA:
undetectable		 3m0wE-5y0qA:
undetectable
3m0wF-5y0qA:
undetectable
3m0wG-5y0qA:
undetectable
3m0wH-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 TYR A  72
PHE A  41
VAL A  76
GLY A  45
 None
 0.83A 3n9jA-5y0qA:
undetectable		 3n9jA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		5 / 11 LEU A  70
ALA A 332
VAL A 360
VAL A  36
ILE A  89
 None
 1.24A 3oxxB-5y0qA:
undetectable		 3oxxB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 THR A 246
TYR A 237
TRP A 244
MET A 214
 None
 1.38A 3wipB-5y0qA:
undetectable
3wipC-5y0qA:
undetectable		 3wipB-5y0qA:
undetectable
3wipC-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 THR A 246
TYR A 237
TRP A 244
MET A 214
 None
 1.44A 3wipC-5y0qA:
undetectable
3wipD-5y0qA:
undetectable		 3wipC-5y0qA:
undetectable
3wipD-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 ASN A 218
ALA A 213
LEU A 226
LEU A 223
 None
 0.93A 4ejgB-5y0qA:
undetectable		 4ejgB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 ASN A 218
ALA A 213
LEU A 226
LEU A 223
 None
 0.93A 4ejgC-5y0qA:
undetectable		 4ejgC-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 LEU A 223
ALA A 228
LEU A 226
SER A  62
 None
 1.14A 4iklA-5y0qA:
undetectable
4iklB-5y0qA:
undetectable		 4iklA-5y0qA:
undetectable
4iklB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		3 / 3 PRO A 179
MET A 180
TYR A 178
 None
 1.10A 4qa0A-5y0qA:
undetectable		 4qa0A-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 8 SER A 240
MET A  58
ALA A  54
SER A  51
 None
 0.98A 5l5fY-5y0qA:
undetectable
5l5fZ-5y0qA:
undetectable		 5l5fY-5y0qA:
undetectable
5l5fZ-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 TYR A 334
ASP A 374
LEU A 373
VAL A  76
 None
 0.84A 5ov9A-5y0qA:
undetectable		 5ov9A-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 7 ARG A 187
PHE A 100
LEU A  98
SER A 172
 APC  A1001 (-2.8A)
None
None
None
 0.90A 5uxcA-5y0qA:
undetectable		 5uxcA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		5 / 12 ARG A  84
ASP A 374
LEU A  73
HIS A 313
THR A 318
 None
 1.39A 5x7pA-5y0qA:
1.0		 5x7pA-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		5 / 12 ARG A  84
ASP A 374
LEU A  73
HIS A 313
THR A 318
 None
 1.42A 5x7pB-5y0qA:
1.4		 5x7pB-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5y0q UPF0348 PROTEIN
B4417_3650
(Bacillus
subtilis) 		4 / 6 PHE A  41
ARG A 309
ALA A 377
GLN A  43
 None
 1.07A 6b89B-5y0qA:
undetectable		 6b89B-5y0qA:
undetectable