SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		5 / 12 HIS A  14
GLY A  16
HIS A  17
SER A 167
GLY A 195
 None
 0.95A 1qu2A-5y0sA:
undetectable		 1qu2A-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		5 / 12 VAL A 326
PHE A 275
PHE A 283
LEU A 279
ARG A 309
 None
 1.49A 3apvB-5y0sA:
undetectable		 3apvB-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 VAL A  66
VAL A  67
THR A  93
THR A 343
 None
 1.20A 3bjwA-5y0sA:
undetectable		 3bjwA-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 VAL A  66
VAL A  67
THR A  93
THR A 343
 None
 1.22A 3bjwG-5y0sA:
undetectable		 3bjwG-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 VAL A  66
VAL A  67
THR A  93
THR A 343
 None
 1.23A 3bjwC-5y0sA:
undetectable		 3bjwC-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 VAL A  66
VAL A  67
THR A  93
THR A 343
 None
 1.19A 3bjwD-5y0sA:
undetectable		 3bjwD-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 LEU A 279
GLY A 278
PHE A 305
ARG A 309
 None
 1.10A 3smtA-5y0sA:
undetectable		 3smtA-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		5 / 11 ILE A  34
ILE A 337
ILE A 349
ALA A 357
VAL A   3
 None
None
None
EDO  A 505 ( 3.8A)
None
 1.01A 4h1nA-5y0sA:
undetectable		 4h1nA-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 GLU A 224
SER A 228
ARG A 221
SER A 208
 None
 1.47A 4k17B-5y0sA:
undetectable		 4k17B-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		4 / 5 GLY A 410
TYR A 398
SER A 399
GLU A 411
 CME  A 409 ( 2.4A)
None
None
None
 1.29A 4xueA-5y0sA:
2.4		 4xueA-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		5 / 12 ILE A  50
ALA A  48
ILE A 213
LEU A 229
PRO A 230
 None
 1.03A 5eajB-5y0sA:
undetectable		 5eajB-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		3 / 3 ALA A 212
ASN A 215
LEU A 216
 None
 0.37A 5i1nB-5y0sA:
undetectable		 5i1nB-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		3 / 3 ALA A 212
ASN A 215
LEU A 216
 None
 0.31A 5i1oC-5y0sA:
undetectable		 5i1oC-5y0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5y0s THERMOTOGA MARITIMA
TMCAL
(Thermotoga
maritima) 		3 / 3 ALA A 212
ASN A 215
LEU A 216
 None
 0.32A 5i1pA-5y0sA:
undetectable		 5i1pA-5y0sA:
undetectable