SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		5 / 12 GLY C  76
GLY C  28
ILE C  55
GLN C  79
SER C 169
 None
 1.11A 1ri4A-5y10C:
undetectable		 1ri4A-5y10C:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		5 / 12 TYR C  44
ILE C  51
GLY C 312
VAL C 178
TYR C  89
 None
 1.39A 2nyrB-5y10C:
undetectable		 2nyrB-5y10C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 6 LEU C 173
TYR C 124
ILE C 175
ARG C 332
 None
 0.72A 2q8hA-5y10C:
undetectable		 2q8hA-5y10C:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		3 / 3 ARG C 332
ARG C 132
PRO C 120
 None
 0.84A 2wljA-5y10C:
undetectable		 2wljA-5y10C:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 6 SER C  97
VAL C  80
TYR C  82
ASP C 100
 None
 1.27A 2x45A-5y10C:
undetectable		 2x45A-5y10C:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 4 ILE C 208
PHE C 213
ILE C 239
THR C 336
 None
 1.16A 3ia4A-5y10C:
undetectable		 3ia4A-5y10C:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 5 ARG C  77
LEU C  54
VAL C  80
ASP C 100
 None
 1.11A 3ufnA-5y10C:
undetectable
3ufnB-5y10C:
undetectable		 3ufnA-5y10C:
16.09
3ufnB-5y10C:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		3 / 4 SER C  45
GLY C 282
GLU C 293
 None
 0.59A 4juoA-5y10C:
undetectable
4juoC-5y10C:
undetectable		 4juoA-5y10C:
20.52
4juoC-5y10C:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 7 PHE C 135
ILE C 239
TYR C 318
ASN C 214
 None
 1.18A 4o7gA-5y10C:
undetectable
4o7gB-5y10C:
undetectable		 4o7gA-5y10C:
20.18
4o7gB-5y10C:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 6 PHE C 135
ILE C 239
TYR C 318
ASN C 214
 None
 1.12A 4o7gB-5y10C:
undetectable		 4o7gB-5y10C:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		5 / 12 PHE C 202
PHE C 213
ILE C 208
ALA C 335
PHE C 225
 None
 0.84A 4wh5A-5y10C:
undetectable		 4wh5A-5y10C:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		5 / 12 LEU C  54
GLY C  75
VAL C  80
SER C 164
GLY C 161
 None
 1.15A 5f9zA-5y10C:
undetectable		 5f9zA-5y10C:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 6 PRO C 265
HIS C  40
ALA C 101
LEU C  96
 None
NAG  C 402 (-4.6A)
None
None
 1.06A 5igiA-5y10C:
undetectable		 5igiA-5y10C:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		4 / 6 GLY C 161
THR C 162
SER C 163
GLY C 146
 None
 0.59A 5k4pA-5y10C:
undetectable		 5k4pA-5y10C:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		3 / 3 LYS C 113
TRP C 141
SER C 115
 None
 1.15A 5nwwA-5y10C:
undetectable		 5nwwA-5y10C:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5y10 MEMBRANE
GLYCOPROTEIN
POLYPROTEIN
(SFTS
phlebovirus) 		5 / 12 TYR C  44
ILE C  25
ASP C  52
ARG C  77
ASP C 100
 None
 1.50A 6c9zA-5y10C:
undetectable		 6c9zA-5y10C:
17.61