SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5y1a -
(-) 		4 / 6 LEU A  73
MET A 234
LEU A  81
HIS A 231
 None
 1.25A 1errB-5y1aA:
undetectable		 1errB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5y1a -
(-) 		4 / 6 HIS A 231
LEU A 200
LEU A 157
PRO A 156
 None
 1.35A 1hz4A-5y1aA:
undetectable		 1hz4A-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5y1a -
(-) 		4 / 5 LEU A  73
ILE A 190
LEU A 191
SER A 192
 None
 0.93A 2byoA-5y1aA:
0.6		 2byoA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5y1a -
(-) 		4 / 5 HIS A 183
TYR A 181
PRO A  31
LYS A  34
 None
 1.42A 3fo7A-5y1aA:
undetectable		 3fo7A-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y1a -
(-) 		4 / 7 PHE A 144
VAL A 126
ILE A 242
GLY A 246
 None
 0.97A 3gssA-5y1aA:
undetectable		 3gssA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y1a -
(-) 		4 / 7 PHE A 144
VAL A 126
ILE A 242
GLY A 246
 None
 0.97A 3gssB-5y1aA:
undetectable		 3gssB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5y1a -
(-) 		3 / 3 HIS A 231
SER A  90
GLU A  20
 None
 0.82A 3s8pA-5y1aA:
undetectable		 3s8pA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5y1a -
(-) 		4 / 6 THR A 193
GLY A 197
ASP A 198
ILE A 210
 None
 0.97A 3w9tF-5y1aA:
undetectable		 3w9tF-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y1a -
(-) 		4 / 8 MET A 168
ILE A 171
VAL A  70
MET A 189
 None
 1.35A 4f4dB-5y1aA:
undetectable		 4f4dB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 5y1a -
(-) 		5 / 9 PHE A 229
LEU A 159
THR A  55
VAL A 187
LEU A 164
 None
 1.08A 4wnvA-5y1aA:
undetectable		 4wnvA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 5y1a -
(-) 		4 / 4 ILE A 190
ARG A  93
TYR A 162
GLU A  20
 None
 0.85A 4zzbD-5y1aA:
undetectable		 4zzbD-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 5y1a -
(-) 		4 / 5 ILE A 190
ARG A  93
TYR A 162
GLU A  20
 None
 0.83A 4zzcE-5y1aA:
undetectable		 4zzcE-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5y1a -
(-) 		4 / 8 LEU A 128
LEU A 250
TYR A 162
GLN A  54
 None
 1.11A 5hbsA-5y1aA:
undetectable		 5hbsA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5y1a -
(-) 		4 / 8 PRO A 106
ILE A  37
ILE A  41
GLU A  42
 None
 0.76A 5mvmA-5y1aA:
undetectable
5mvmB-5y1aA:
undetectable		 5mvmA-5y1aA:
undetectable
5mvmB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5y1a -
(-) 		3 / 3 LYS A  10
PRO A 123
LYS A  15
 None
 0.91A 5y9yA-5y1aA:
undetectable		 5y9yA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5y1a -
(-) 		4 / 6 THR A 186
PRO A 170
GLN A 174
ILE A  63
 None
 1.33A 6ef6A-5y1aA:
undetectable		 6ef6A-5y1aA:
undetectable