SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 GLY A 192
ALA A 188
ASP A 187
THR A 296
ILE A 249
 None
 0.91A 1fb7A-5y1gA:
undetectable		 1fb7A-5y1gA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 11 GLY A 192
ALA A 188
ASP A 187
THR A 296
ILE A 249
 None
 0.90A 1ohrA-5y1gA:
undetectable		 1ohrA-5y1gA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		6 / 11 GLY A   6
ASP A  32
LEU A  33
ASP A  47
ALA A  70
VAL A  87
 NAD  A 402 (-3.6A)
NAD  A 402 (-2.8A)
NAD  A 402 (-4.3A)
NAD  A 402 (-3.0A)
NAD  A 402 (-3.7A)
NAD  A 402 (-4.3A)
 0.31A 1uayA-5y1gA:
17.1		 1uayA-5y1gA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		6 / 10 GLY A   6
ASP A  32
LEU A  33
ASP A  47
ALA A  70
VAL A  87
 NAD  A 402 (-3.6A)
NAD  A 402 (-2.8A)
NAD  A 402 (-4.3A)
NAD  A 402 (-3.0A)
NAD  A 402 (-3.7A)
NAD  A 402 (-4.3A)
 0.37A 1uayB-5y1gA:
17.0		 1uayB-5y1gA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 LEU A 204
LEU A 166
GLN A  10
LEU A  73
THR A 202
 None
NAD  A 402 (-3.8A)
NAD  A 402 (-3.8A)
AKB  A 401 (-4.1A)
None
 1.43A 1ya3A-5y1gA:
undetectable		 1ya3A-5y1gA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 LEU A 204
LEU A 166
GLN A  10
LEU A  73
THR A 202
 None
NAD  A 402 (-3.8A)
NAD  A 402 (-3.8A)
AKB  A 401 (-4.1A)
None
 1.45A 2aa5B-5y1gA:
undetectable		 2aa5B-5y1gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 7 THR A 124
PRO A 125
GLY A 116
ASP A 118
 None
 1.00A 2ddwB-5y1gA:
2.5		 2ddwB-5y1gA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 LEU A 204
LEU A 166
GLN A  10
LEU A  73
THR A 202
 None
NAD  A 402 (-3.8A)
NAD  A 402 (-3.8A)
AKB  A 401 (-4.1A)
None
 1.47A 2oaxA-5y1gA:
undetectable		 2oaxA-5y1gA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 8 GLY A 192
ALA A 188
ASP A 187
THR A 296
ILE A 249
 None
 0.99A 3el0A-5y1gA:
undetectable		 3el0A-5y1gA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 8 LEU A  15
TYR A  67
PHE A 107
TYR A 163
 None
None
None
NAD  A 402 (-4.9A)
 1.36A 3po7A-5y1gA:
2.3		 3po7A-5y1gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 GLY A   6
ILE A  11
ASP A  32
LEU A  33
ASP A  47
 NAD  A 402 (-3.6A)
NAD  A 402 (-3.9A)
NAD  A 402 (-2.8A)
NAD  A 402 (-4.3A)
NAD  A 402 (-3.0A)
 1.18A 3q87B-5y1gA:
4.0		 3q87B-5y1gA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 ASN A 131
PRO A 132
GLY A 116
ASN A 232
ASP A 279
 None
 0.97A 3r24A-5y1gA:
4.5		 3r24A-5y1gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 GLY A 192
ALA A 188
ASP A 187
THR A 296
ILE A 249
 None
 0.96A 3tkgC-5y1gA:
undetectable		 3tkgC-5y1gA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 ARG A 203
ILE A 275
ALA A 113
THR A 134
ALA A 268
 None
None
AKB  A 401 ( 4.4A)
None
None
 1.35A 3ua1A-5y1gA:
undetectable		 3ua1A-5y1gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 ASP A 179
ILE A 213
THR A 178
PHE A 107
ALA A  70
 None
None
AKB  A 401 (-3.3A)
None
NAD  A 402 (-3.7A)
 1.32A 3ua1A-5y1gA:
undetectable		 3ua1A-5y1gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 8 TYR A  39
VAL A   4
VAL A  66
ILE A  29
 None
 1.03A 4aftD-5y1gA:
undetectable
4aftE-5y1gA:
undetectable		 4aftD-5y1gA:
19.82
4aftE-5y1gA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 4 LYS A  97
LEU A  96
GLU A  93
LEU A 146
 None
 1.41A 4k4yE-5y1gA:
undetectable		 4k4yE-5y1gA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 11 LEU A 217
TYR A  67
ILE A  11
MET A 209
LEU A 166
 None
None
NAD  A 402 (-3.9A)
None
NAD  A 402 (-3.8A)
 1.23A 4lhmA-5y1gA:
3.2		 4lhmA-5y1gA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 7 PRO A 272
PHE A 115
TRP A 271
TYR A 136
 None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
 1.48A 4v2zA-5y1gA:
undetectable		 4v2zA-5y1gA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		6 / 12 ALA A 215
LEU A 219
LEU A 235
ARG A 281
GLY A 165
LEU A 166
 None
None
None
None
AKB  A 401 ( 3.7A)
NAD  A 402 (-3.8A)
 1.45A 4xi3B-5y1gA:
undetectable		 4xi3B-5y1gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		6 / 12 ALA A 215
LEU A 219
LEU A 235
ARG A 281
GLY A 165
LEU A 166
 None
None
None
None
AKB  A 401 ( 3.7A)
NAD  A 402 (-3.8A)
 1.44A 4xi3C-5y1gA:
undetectable		 4xi3C-5y1gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 8 PRO A 272
PHE A 115
TRP A 271
TYR A 136
 None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
 1.45A 5amiB-5y1gA:
undetectable		 5amiB-5y1gA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 8 PRO A 272
PHE A 115
TRP A 271
TYR A 136
 None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
 1.36A 5amkA-5y1gA:
undetectable		 5amkA-5y1gA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 5 GLN A 104
HIS A   0
ILE A  63
ILE A   2
 None
 1.18A 5dnuA-5y1gA:
4.6		 5dnuA-5y1gA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 5 GLN A 104
HIS A   0
ILE A  63
ILE A   2
 None
 1.17A 5dnvA-5y1gA:
5.0		 5dnvA-5y1gA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 GLY A   6
ASP A  32
LEU A  33
ILE A  48
VAL A  87
 NAD  A 402 (-3.6A)
NAD  A 402 (-2.8A)
NAD  A 402 (-4.3A)
NAD  A 402 (-3.9A)
NAD  A 402 (-4.3A)
 0.74A 5dpdB-5y1gA:
4.7		 5dpdB-5y1gA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		5 / 12 ILE A 161
GLY A 160
ASP A 157
LEU A  15
LEU A  19
 None
 1.24A 5nfjB-5y1gA:
undetectable		 5nfjB-5y1gA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 7 PRO A 272
PHE A 115
TRP A 271
TYR A 136
 None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
 1.48A 5oh1B-5y1gA:
undetectable		 5oh1B-5y1gA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 7 PRO A 272
PHE A 115
TRP A 271
TYR A 136
 None
None
AKB  A 401 (-4.5A)
AKB  A 401 (-4.5A)
 1.44A 5oh3B-5y1gA:
undetectable		 5oh3B-5y1gA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY
(uncultured
archaeon
MedDCM-OCT-S05-C
57) 		4 / 6 GLU A 246
ARG A 200
GLU A 244
ALA A 242
 None
 1.01A 6an0A-5y1gA:
2.6		 6an0A-5y1gA:
23.54