SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y1i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 11 GLN A 402
ILE A 296
ALA A 404
VAL A 151
LEU A 373
 None
 1.21A 1n4hA-5y1iA:
undetectable		 1n4hA-5y1iA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 12 TYR A  82
ALA A 306
GLY A 319
ILE A 309
SER A  74
 None
 1.12A 1ve3A-5y1iA:
undetectable		 1ve3A-5y1iA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 6 ILE A 233
PRO A 117
LEU A 245
ILE A 220
 None
 0.85A 2q83B-5y1iA:
undetectable		 2q83B-5y1iA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 10 THR A 134
VAL A 371
VAL A 162
ILE A 133
VAL A 158
 None
 1.32A 2qboA-5y1iA:
38.9		 2qboA-5y1iA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 5 LYS A 317
ASP A 308
ARG A  72
GLU A 307
 None
 1.21A 2x8oA-5y1iA:
undetectable		 2x8oA-5y1iA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		3 / 3 ALA A 248
THR A 252
CYH A 363
 HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.1A)
 0.49A 3e4eA-5y1iA:
31.6		 3e4eA-5y1iA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		3 / 3 ALA A 248
THR A 252
CYH A 363
 HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.1A)
 0.42A 3e4eB-5y1iA:
31.2		 3e4eB-5y1iA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 9 LEU A 290
HIS A 353
GLU A 288
ILE A 296
LEU A 294
 None
 1.21A 3hy7A-5y1iA:
undetectable		 3hy7A-5y1iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 9 LEU A 290
HIS A 353
GLU A 288
ILE A 296
LEU A 294
 None
 1.21A 3hy7B-5y1iA:
undetectable		 3hy7B-5y1iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 8 PHE A 324
ILE A 311
ALA A 305
VAL A 314
 None
 0.80A 3me6B-5y1iA:
31.3		 3me6B-5y1iA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 9 VAL A  58
PHE A 324
ILE A 311
ALA A 305
VAL A 314
 None
 1.28A 3me6D-5y1iA:
15.2		 3me6D-5y1iA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 10 ILE A 138
ALA A 153
LEU A 380
LEU A 150
VAL A 148
 None
 1.24A 3o02A-5y1iA:
undetectable
3o02B-5y1iA:
undetectable		 3o02A-5y1iA:
22.43
3o02B-5y1iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 12 ASN A 181
ILE A 185
GLY A 247
ALA A 248
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
 1.02A 3rukB-5y1iA:
30.7		 3rukB-5y1iA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 11 PHE A  89
ASN A 181
GLY A 247
ALA A 248
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
 1.13A 3rukD-5y1iA:
30.7		 3rukD-5y1iA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 6 MET A 256
LEU A 294
PRO A  31
TYR A 293
 HEM  A 501 (-4.8A)
None
None
None
 0.99A 3vkxA-5y1iA:
undetectable		 3vkxA-5y1iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 8 THR A 261
TYR A 293
LEU A 373
MET A 256
 None
None
None
HEM  A 501 (-4.8A)
 0.93A 3wipG-5y1iA:
undetectable
3wipH-5y1iA:
undetectable		 3wipG-5y1iA:
19.69
3wipH-5y1iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 8 LEU A 373
MET A 256
THR A 261
TYR A 293
 None
HEM  A 501 (-4.8A)
None
None
 1.14A 3wipF-5y1iA:
undetectable
3wipJ-5y1iA:
undetectable		 3wipF-5y1iA:
19.69
3wipJ-5y1iA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 6 HIS A 346
GLU A 273
ASP A 279
SER A 277
 None
 1.35A 4apjA-5y1iA:
2.1
4apjP-5y1iA:
undetectable		 4apjA-5y1iA:
19.83
4apjP-5y1iA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		4 / 8 ILE A 322
ILE A 311
ALA A  66
VAL A  58
 None
 0.77A 4jltA-5y1iA:
31.9		 4jltA-5y1iA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 12 ASN A 181
ILE A 185
GLY A 247
ALA A 248
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
 1.02A 4nkvC-5y1iA:
30.9		 4nkvC-5y1iA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 12 ASN A 181
ILE A 185
GLY A 247
ALA A 248
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
 1.05A 4nkvD-5y1iA:
31.2		 4nkvD-5y1iA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 12 ASN A 181
ILE A 185
GLY A 247
ALA A 248
THR A 252
 None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
 1.02A 4nkxA-5y1iA:
30.5		 4nkxA-5y1iA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		3 / 3 PRO A  43
LEU A  44
GLN A  64
 None
 0.44A 4pevB-5y1iA:
undetectable		 4pevB-5y1iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		5 / 12 ASN A 255
GLY A 260
ALA A 263
LEU A 389
LEU A 393
 None
 1.35A 5x23A-5y1iA:
32.3		 5x23A-5y1iA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5y1i CYTOCHROME P450
(Streptomyces
graminofaciens) 		3 / 3 ARG A  36
ARG A 347
ARG A 342
 None
 1.09A 6bplA-5y1iA:
undetectable
6bplB-5y1iA:
undetectable		 6bplA-5y1iA:
13.71
6bplB-5y1iA:
13.71