SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 5y28 -
(-) 		5 / 12 ALA A 214
ASP A 213
ILE A 169
LEU A 196
ILE A 210
 None
 1.30A 1d1gA-5y28A:
undetectable		 1d1gA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5y28 -
(-) 		5 / 12 ASN A 114
GLY A 100
VAL A 126
ALA A 149
LEU A 148
 None
 1.12A 1gs4A-5y28A:
undetectable		 1gs4A-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5y28 -
(-) 		5 / 9 ILE A 226
ILE A 178
VAL A 188
THR A 189
ALA A 214
 None
 1.09A 2m9qA-5y28A:
6.3		 2m9qA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5y28 -
(-) 		5 / 12 GLY A 102
GLY A 223
GLY A 219
ILE A 111
VAL A  56
 None
 1.02A 2oxtC-5y28A:
undetectable		 2oxtC-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5y28 -
(-) 		5 / 11 HIS A 116
LEU A 225
GLY A 223
VAL A 103
ALA A 252
 None
 1.08A 2yy8A-5y28A:
undetectable
2yy8B-5y28A:
undetectable		 2yy8A-5y28A:
undetectable
2yy8B-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5y28 -
(-) 		5 / 11 LEU A 225
GLY A 222
VAL A 103
ILE A 210
ALA A 252
 None
 1.15A 2yy8A-5y28A:
undetectable
2yy8B-5y28A:
undetectable		 2yy8A-5y28A:
undetectable
2yy8B-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5y28 -
(-) 		5 / 11 LEU A 225
GLY A 223
VAL A 103
ILE A 210
ALA A 252
 None
 0.89A 2yy8A-5y28A:
undetectable
2yy8B-5y28A:
undetectable		 2yy8A-5y28A:
undetectable
2yy8B-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5y28 -
(-) 		5 / 12 ILE A 128
ASN A  57
SER A 101
GLY A 185
GLY A 183
 None
 1.25A 2zw9A-5y28A:
undetectable		 2zw9A-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5y28 -
(-) 		4 / 7 VAL A 140
ILE A 105
TYR A 110
ILE A 111
 None
 1.04A 3hgxA-5y28A:
undetectable		 3hgxA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5y28 -
(-) 		4 / 6 THR A 261
SER A 166
ILE A 210
ASP A 147
 None
 1.12A 3q70A-5y28A:
undetectable		 3q70A-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5y28 -
(-) 		3 / 3 ASN A 256
ASP A 165
ASN A 167
 None
 0.64A 4agaA-5y28A:
undetectable		 4agaA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5y28 -
(-) 		4 / 7 LEU A 225
ILE A 105
ILE A 161
VAL A 103
 None
 0.87A 4ojbA-5y28A:
undetectable		 4ojbA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5y28 -
(-) 		5 / 9 THR A 138
ALA A 137
VAL A 262
GLY A 141
ALA A 149
 None
 1.22A 4qvnK-5y28A:
undetectable
4qvnL-5y28A:
undetectable		 4qvnK-5y28A:
undetectable
4qvnL-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5y28 -
(-) 		5 / 9 THR A 138
ALA A 137
VAL A 262
GLY A 141
ALA A 149
 None
 1.22A 4qvnY-5y28A:
undetectable
4qvnZ-5y28A:
undetectable		 4qvnY-5y28A:
undetectable
4qvnZ-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5y28 -
(-) 		5 / 9 ALA A 137
ILE A 266
VAL A 262
GLY A 141
VAL A 112
 None
 1.32A 4r20B-5y28A:
undetectable		 4r20B-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5y28 -
(-) 		5 / 12 GLY A 277
ASN A 335
THR A 330
VAL A 322
LEU A 280
 EDO  A 401 ( 4.7A)
None
None
None
None
 1.05A 5kocA-5y28A:
undetectable		 5kocA-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5y28 -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.88A 5njvC-5y28A:
undetectable		 5njvC-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 5y28 -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.89A 5wz2B-5y28A:
undetectable		 5wz2B-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 5y28 -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.89A 5wz2C-5y28A:
undetectable		 5wz2C-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5y28 -
(-) 		5 / 12 VAL A 126
ILE A  58
SER A 106
VAL A 112
ILE A 151
 None
 1.44A 6gsdA-5y28A:
undetectable		 6gsdA-5y28A:
undetectable