SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5y2d -
(-) 		5 / 9 ILE A 226
ILE A 178
VAL A 188
THR A 189
ALA A 214
 None
 1.13A 2m9qA-5y2dA:
1.1		 2m9qA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5y2d -
(-) 		5 / 9 LEU A 225
ILE A 226
ILE A 178
VAL A 188
ALA A 214
 None
 1.14A 2m9qA-5y2dA:
1.1		 2m9qA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5y2d -
(-) 		5 / 11 LEU A 225
GLY A 223
VAL A  55
ILE A 210
ALA A 252
 None
 1.11A 2yy8A-5y2dA:
undetectable
2yy8B-5y2dA:
undetectable		 2yy8A-5y2dA:
undetectable
2yy8B-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5y2d -
(-) 		5 / 12 GLY A 179
VAL A  55
GLY A 102
ASN A 220
HIS A 116
 None
 1.41A 3f8wB-5y2dA:
undetectable		 3f8wB-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.86A 3p97A-5y2dA:
undetectable		 3p97A-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.86A 4ctjA-5y2dA:
undetectable		 4ctjA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.85A 4ctkA-5y2dA:
undetectable		 4ctkA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5y2d -
(-) 		5 / 12 ILE A 105
GLY A 223
GLY A 102
ALA A  54
ALA A 177
 None
 1.01A 4kicB-5y2dA:
undetectable		 4kicB-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 100
GLY A 222
PRO A 218
ALA A 238
ALA A 149
 None
 1.10A 5bw4B-5y2dA:
undetectable		 5bw4B-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.84A 5e9qA-5y2dA:
undetectable		 5e9qA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.81A 5ec8A-5y2dA:
undetectable		 5ec8A-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.83A 5ehgA-5y2dA:
undetectable		 5ehgA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.95A 5ehgC-5y2dA:
undetectable		 5ehgC-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.85A 5ehiA-5y2dA:
undetectable		 5ehiA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.87A 5eifA-5y2dA:
undetectable		 5eifA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.83A 5eiwA-5y2dA:
undetectable		 5eiwA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.88A 5ekxB-5y2dA:
undetectable		 5ekxB-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.94A 5ikmA-5y2dA:
undetectable		 5ikmA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.92A 5kqrA-5y2dA:
undetectable		 5kqrA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.90A 5kqsA-5y2dA:
undetectable		 5kqsA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5y2d -
(-) 		5 / 12 VAL A 193
ASP A 173
ALA A 252
GLY A 231
LEU A 232
 None
 1.25A 5m54E-5y2dA:
undetectable		 5m54E-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.89A 5njvB-5y2dA:
undetectable		 5njvB-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.93A 5njvC-5y2dA:
undetectable		 5njvC-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 1.00A 5njvD-5y2dA:
undetectable		 5njvD-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.89A 5vimA-5y2dA:
undetectable		 5vimA-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.88A 5vimB-5y2dA:
undetectable		 5vimB-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.88A 5wz2A-5y2dA:
undetectable		 5wz2A-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.85A 5wz2B-5y2dA:
undetectable		 5wz2B-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 5y2d -
(-) 		5 / 12 GLY A 234
GLY A 102
GLY A 222
VAL A 126
ILE A 111
 None
 0.87A 5wz2C-5y2dA:
undetectable		 5wz2C-5y2dA:
undetectable