SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 6 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.11A 1nsiA-5y2pA:
undetectable
1nsiB-5y2pA:
undetectable		 1nsiA-5y2pA:
undetectable
1nsiB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 6 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.14A 1nsiA-5y2pA:
undetectable
1nsiB-5y2pA:
undetectable		 1nsiA-5y2pA:
undetectable
1nsiB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 6 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.10A 1nsiC-5y2pA:
undetectable
1nsiD-5y2pA:
undetectable		 1nsiC-5y2pA:
undetectable
1nsiD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 6 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.12A 1nsiC-5y2pA:
undetectable
1nsiD-5y2pA:
undetectable		 1nsiC-5y2pA:
undetectable
1nsiD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 7 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.14A 2nsiA-5y2pA:
0.0
2nsiB-5y2pA:
0.0		 2nsiA-5y2pA:
undetectable
2nsiB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 7 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.11A 2nsiA-5y2pA:
0.0
2nsiB-5y2pA:
0.0		 2nsiA-5y2pA:
undetectable
2nsiB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 7 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.10A 2nsiC-5y2pA:
undetectable
2nsiD-5y2pA:
undetectable		 2nsiC-5y2pA:
undetectable
2nsiD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5y2p -
(-) 		4 / 7 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.10A 2nsiC-5y2pA:
undetectable
2nsiD-5y2pA:
undetectable		 2nsiC-5y2pA:
undetectable
2nsiD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 7 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.11A 3e7gA-5y2pA:
undetectable
3e7gB-5y2pA:
undetectable		 3e7gA-5y2pA:
undetectable
3e7gB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 7 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.08A 3e7gA-5y2pA:
undetectable
3e7gB-5y2pA:
undetectable		 3e7gA-5y2pA:
undetectable
3e7gB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 7 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.05A 3e7gC-5y2pA:
undetectable
3e7gD-5y2pA:
undetectable		 3e7gC-5y2pA:
undetectable
3e7gD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 8 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.05A 3e7gC-5y2pA:
undetectable
3e7gD-5y2pA:
undetectable		 3e7gC-5y2pA:
undetectable
3e7gD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5y2p -
(-) 		5 / 12 TYR A  11
LEU A  58
GLY A  55
ALA A 100
LEU A 115
 None
 1.04A 3vywC-5y2pA:
undetectable		 3vywC-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 8 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.12A 4cx7A-5y2pA:
undetectable
4cx7B-5y2pA:
undetectable		 4cx7A-5y2pA:
undetectable
4cx7B-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 8 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.10A 4cx7A-5y2pA:
undetectable
4cx7B-5y2pA:
undetectable		 4cx7A-5y2pA:
undetectable
4cx7B-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 8 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.16A 4cx7C-5y2pA:
undetectable
4cx7D-5y2pA:
undetectable		 4cx7C-5y2pA:
undetectable
4cx7D-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5y2p -
(-) 		4 / 7 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.05A 4cx7C-5y2pA:
undetectable
4cx7D-5y2pA:
undetectable		 4cx7C-5y2pA:
undetectable
4cx7D-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5y2p -
(-) 		4 / 6 GLU A 243
ARG A 263
GLU A  34
SER A 239
 None
 1.40A 4kr3A-5y2pA:
undetectable		 4kr3A-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5y2p -
(-) 		6 / 12 THR A  91
THR A 222
GLU A 225
GLU A 217
ASN A 226
GLN A 167
 None
 1.49A 4njgA-5y2pA:
undetectable		 4njgA-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5y2p -
(-) 		5 / 12 THR A  91
THR A 222
GLU A 225
ASN A 226
GLN A 167
 None
 1.43A 4njgB-5y2pA:
undetectable		 4njgB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5y2p -
(-) 		6 / 12 THR A  91
THR A 222
GLU A 225
GLU A 217
ASN A 226
GLN A 167
 None
 1.49A 4njjB-5y2pA:
undetectable		 4njjB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5y2p -
(-) 		4 / 7 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.11A 4nosA-5y2pA:
undetectable
4nosB-5y2pA:
undetectable		 4nosA-5y2pA:
undetectable
4nosB-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5y2p -
(-) 		4 / 7 ARG A  30
ILE A 236
PHE A 264
GLU A 262
 None
 1.02A 4nosC-5y2pA:
undetectable
4nosD-5y2pA:
undetectable		 4nosC-5y2pA:
undetectable
4nosD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5y2p -
(-) 		4 / 6 PHE A 264
GLU A 262
ARG A  30
ILE A 236
 None
 1.11A 4nosC-5y2pA:
undetectable
4nosD-5y2pA:
undetectable		 4nosC-5y2pA:
undetectable
4nosD-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5y2p -
(-) 		4 / 7 TYR A  87
ALA A  18
ILE A  92
LEU A  23
 None
 0.86A 4uymA-5y2pA:
undetectable		 4uymA-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5y2p -
(-) 		5 / 12 GLN A 310
LEU A 267
GLN A 266
PRO A  33
ILE A  32
 None
 1.36A 5uhdC-5y2pA:
1.8		 5uhdC-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5y2p -
(-) 		4 / 4 VAL A 228
LEU A 261
ASN A 226
ASP A 218
 None
 1.38A 5vcyA-5y2pA:
undetectable		 5vcyA-5y2pA:
undetectable