SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 8 PHE A 286
PHE A 161
ALA A 103
LEU A 125
 None
 1.02A 1x8vA-5y2vA:
undetectable		 1x8vA-5y2vA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.05A 3fl9A-5y2vA:
undetectable		 3fl9A-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PO4  A 401 (-4.0A)
 1.25A 3fl9B-5y2vA:
undetectable		 3fl9B-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 11 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PO4  A 401 (-4.0A)
 1.31A 3fl9C-5y2vA:
2.2		 3fl9C-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.15A 3fl9D-5y2vA:
undetectable		 3fl9D-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 10 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PO4  A 401 (-4.0A)
 1.19A 3fl9E-5y2vA:
undetectable		 3fl9E-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.09A 3fl9F-5y2vA:
undetectable		 3fl9F-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PO4  A 401 (-4.0A)
 1.34A 3fl9G-5y2vA:
2.5		 3fl9G-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 9 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PO4  A 401 (-4.0A)
 1.24A 3fl9H-5y2vA:
undetectable		 3fl9H-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 204
VAL A 240
ILE A 184
PHE A 209
THR A 201
 None
None
None
None
PO4  A 401 (-4.0A)
 1.20A 3freX-5y2vA:
undetectable		 3freX-5y2vA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 4 LEU A 111
PRO A 108
LEU A 125
ARG A  94
 None
 1.42A 3hcoA-5y2vA:
undetectable		 3hcoA-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 204
VAL A 240
ILE A 184
PHE A 209
THR A 201
 None
None
None
None
PO4  A 401 (-4.0A)
 1.13A 3jw5A-5y2vA:
undetectable		 3jw5A-5y2vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 204
VAL A 240
ILE A 184
PHE A 209
THR A 201
 None
None
None
None
PO4  A 401 (-4.0A)
 1.11A 3jw5B-5y2vA:
undetectable		 3jw5B-5y2vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A  41
GLN A   2
THR A  44
HIS A   6
 None
 1.49A 3n58C-5y2vA:
undetectable		 3n58C-5y2vA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 7 ILE A 260
VAL A 168
ILE A 238
GLU A 190
 None
 0.98A 4zzbC-5y2vA:
undetectable
4zzbD-5y2vA:
undetectable		 4zzbC-5y2vA:
undetectable
4zzbD-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		3 / 3 ASP A  72
ARG A  96
ARG A 136
 None
 0.89A 5eajB-5y2vA:
undetectable		 5eajB-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		3 / 3 ILE A 182
PRO A 183
ILE A 260
 None
 0.42A 5hw8F-5y2vA:
undetectable		 5hw8F-5y2vA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 7 HIS A   0
ASP A  72
THR A  69
HIS A  -1
 None
 1.25A 5iy5A-5y2vA:
undetectable
5iy5C-5y2vA:
undetectable		 5iy5A-5y2vA:
undetectable
5iy5C-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 231
ILE A 169
ALA A 170
LEU A 255
 None
 0.70A 5te8B-5y2vA:
undetectable		 5te8B-5y2vA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 6 HIS A   0
ASP A  72
THR A  69
HIS A  -1
 None
 1.24A 5x1bN-5y2vA:
undetectable
5x1bP-5y2vA:
undetectable		 5x1bN-5y2vA:
undetectable
5x1bP-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 7 HIS A   0
ASP A  72
THR A  69
HIS A  -1
 None
 1.26A 5x1fN-5y2vA:
undetectable
5x1fP-5y2vA:
undetectable		 5x1fN-5y2vA:
undetectable
5x1fP-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 8 HIS A   0
ASP A  72
THR A  69
HIS A  -1
 None
 1.23A 5z85A-5y2vA:
undetectable
5z85C-5y2vA:
undetectable
5z85P-5y2vA:
undetectable		 5z85A-5y2vA:
undetectable
5z85C-5y2vA:
undetectable
5z85P-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 7 HIS A   0
ASP A  72
THR A  69
HIS A  -1
 None
 1.27A 6nmfN-5y2vA:
undetectable
6nmfP-5y2vA:
undetectable		 6nmfN-5y2vA:
undetectable
6nmfP-5y2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 6 HIS A   0
ASP A  72
THR A  69
HIS A  -1
 None
 1.27A 6nmpA-5y2vA:
undetectable
6nmpC-5y2vA:
undetectable		 6nmpA-5y2vA:
undetectable
6nmpC-5y2vA:
undetectable