SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 6 ASN A 225
ASN A 164
SER A 148
THR A 201
 None
PGA  A 401 (-3.1A)
PGA  A 401 (-3.5A)
PGA  A 401 (-3.6A)
 1.14A 1h7xA-5y2wA:
undetectable		 1h7xA-5y2wA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 6 ASN A 225
ASN A 164
SER A 148
THR A 201
 None
PGA  A 401 (-3.1A)
PGA  A 401 (-3.5A)
PGA  A 401 (-3.6A)
 1.12A 1h7xB-5y2wA:
undetectable		 1h7xB-5y2wA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 6 ASN A 225
ASN A 164
SER A 148
THR A 201
 None
PGA  A 401 (-3.1A)
PGA  A 401 (-3.5A)
PGA  A 401 (-3.6A)
 1.14A 1h7xC-5y2wA:
undetectable		 1h7xC-5y2wA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 6 ASN A 225
ASN A 164
SER A 148
THR A 201
 None
PGA  A 401 (-3.1A)
PGA  A 401 (-3.5A)
PGA  A 401 (-3.6A)
 1.13A 1h7xD-5y2wA:
undetectable		 1h7xD-5y2wA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 290
VAL A 127
LEU A 111
LEU A 125
LEU A 110
 None
 1.18A 1mx1B-5y2wA:
undetectable		 1mx1B-5y2wA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 290
VAL A 127
LEU A 111
LEU A 125
LEU A 110
 None
 1.10A 1mx1C-5y2wA:
undetectable		 1mx1C-5y2wA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A 224
ILE A 169
THR A 102
THR A 101
 None
None
PGA  A 401 (-2.7A)
PGA  A 401 (-2.8A)
 0.97A 1sbrB-5y2wA:
undetectable		 1sbrB-5y2wA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 8 PHE A 286
PHE A 161
ALA A 103
LEU A 125
 None
 1.03A 1x8vA-5y2wA:
undetectable		 1x8vA-5y2wA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 170
ALA A 231
GLY A 234
GLY A 237
ILE A 193
 None
 1.04A 2v7bA-5y2wA:
undetectable		 2v7bA-5y2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 170
ALA A 231
GLY A 234
GLY A 237
ILE A 193
 None
 1.03A 2v7bB-5y2wA:
undetectable		 2v7bB-5y2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 124
VAL A 123
ARG A  94
ILE A 282
SER A 280
 None
 1.25A 2vdyB-5y2wA:
undetectable		 2vdyB-5y2wA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.11A 3fl9A-5y2wA:
undetectable		 3fl9A-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PGA  A 401 (-3.6A)
 1.36A 3fl9B-5y2wA:
undetectable		 3fl9B-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 11 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PGA  A 401 (-3.6A)
 1.42A 3fl9C-5y2wA:
undetectable		 3fl9C-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.22A 3fl9D-5y2wA:
undetectable		 3fl9D-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 10 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PGA  A 401 (-3.6A)
 1.31A 3fl9E-5y2wA:
undetectable		 3fl9E-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.14A 3fl9F-5y2wA:
undetectable		 3fl9F-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		6 / 12 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
THR A 201
 None
None
None
None
None
PGA  A 401 (-3.6A)
 1.45A 3fl9G-5y2wA:
undetectable		 3fl9G-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
 None
 1.20A 3fl9H-5y2wA:
undetectable		 3fl9H-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 204
VAL A 240
ILE A 184
PHE A 209
THR A 201
 None
None
None
None
PGA  A 401 (-3.6A)
 1.19A 3fl9H-5y2wA:
undetectable		 3fl9H-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 204
VAL A 240
ILE A 184
PHE A 209
THR A 201
 None
None
None
None
PGA  A 401 (-3.6A)
 1.22A 3jw5A-5y2wA:
undetectable		 3jw5A-5y2wA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		4 / 7 ILE A 260
VAL A 168
ILE A 238
GLU A 190
 None
 0.96A 4zzbC-5y2wA:
undetectable
4zzbD-5y2wA:
undetectable		 4zzbC-5y2wA:
undetectable
4zzbD-5y2wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		3 / 3 ILE A 182
PRO A 183
ILE A 260
 None
 0.41A 5hw8F-5y2wA:
undetectable		 5hw8F-5y2wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A 106
ILE A 107
MET A 297
ALA A 272
ILE A 146
 None
 1.28A 5mlmA-5y2wA:
undetectable		 5mlmA-5y2wA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASN A 181
PRO A 183
ILE A 260
VAL A 168
HIS A 174
 None
 1.33A 6j21A-5y2wA:
undetectable		 6j21A-5y2wA:
undetectable