SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
4 / 7 ALA B 434
TYR B 433
SER B 351
ALA B 349
None
1.06A 1k5qA-5y2zB:
undetectable
1k5qB-5y2zB:
undetectable
1k5qA-5y2zB:
undetectable
1k5qB-5y2zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
3 / 3 ASP B 240
GLU B 383
TYR B 433
None
0.83A 1wsvA-5y2zB:
undetectable
1wsvA-5y2zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
4 / 7 THR B 545
GLN B 230
ILE B 547
SER B 236
None
1.11A 2xytI-5y2zB:
undetectable
2xytI-5y2zB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
4 / 7 GLN B 230
ILE B 530
SER B 229
TRP B 265
None
1.42A 2xz5D-5y2zB:
undetectable
2xz5E-5y2zB:
undetectable
2xz5D-5y2zB:
undetectable
2xz5E-5y2zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
5 / 12 ILE B 278
GLY B 280
PHE B 318
ALA B 300
VAL B 299
None
0.95A 3jb2A-5y2zB:
undetectable
3jb2A-5y2zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
3 / 3 LEU B 385
TRP B 460
GLY B 461
None
0.79A 3l35A-5y2zB:
undetectable
3l35H-5y2zB:
undetectable
3l35A-5y2zB:
undetectable
3l35H-5y2zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
4 / 6 THR B 545
GLN B 230
ILE B 547
SER B 236
None
1.28A 3peoG-5y2zB:
undetectable
3peoG-5y2zB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo
sapiens)
4 / 7 ASN B 531
GLU B 248
ILE B 530
ASN B 534
None
1.11A 4d39B-5y2zB:
undetectable
4d39B-5y2zB:
undetectable