SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 134
PHE A 135
SER A  83
LEU A 151
 None
 1.04A 1qcaA-5y30A:
undetectable		 1qcaA-5y30A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A  96
ILE A  82
PHE A 135
THR A 134
LEU A 120
 None
 1.11A 2m9qA-5y30A:
undetectable		 2m9qA-5y30A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A  96
ILE A 122
PHE A 135
THR A 134
LEU A 120
 None
 1.15A 2m9qA-5y30A:
undetectable		 2m9qA-5y30A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A  61
PHE A  98
ILE A 122
PHE A 111
 None
 0.97A 2q6hA-5y30A:
undetectable		 2q6hA-5y30A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A  61
PHE A  98
ILE A 122
PHE A 111
 None
 0.97A 2qb4A-5y30A:
undetectable		 2qb4A-5y30A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A  77
PHE A  98
ILE A 122
PHE A 111
 None
 1.22A 2qeiA-5y30A:
undetectable		 2qeiA-5y30A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE A  87
SER A  86
ILE A 106
PHE A 111
PHE A  98
 None
 1.37A 3a9eB-5y30A:
undetectable		 3a9eB-5y30A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A  90
PHE A  87
PHE A 111
LEU A 120
PHE A  98
 None
 1.46A 3apxA-5y30A:
undetectable		 3apxA-5y30A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE A  98
PHE A 111
ILE A  82
THR A 134
 None
 0.76A 4ejjC-5y30A:
undetectable		 4ejjC-5y30A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 158
PHE A 121
SER A 131
HIS A 133
 None
 1.28A 4rzvB-5y30A:
undetectable		 4rzvB-5y30A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 TRP A 187
VAL A 185
LEU A 170
TRP A 183
 None
 1.50A 5qjqA-5y30A:
undetectable
5qjqB-5y30A:
undetectable		 5qjqA-5y30A:
undetectable
5qjqB-5y30A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 111
ALA A 110
SER A 131
ASN A 125
 None
 0.69A 6f88A-5y30A:
undetectable		 6f88A-5y30A:
22.50